Aromasin/Exemestane

Aromasin is the new generation of AI, it's suicidal, the difference being with the other AI's is Aromasin will actually destroy/kill a certain percentage of your aromatase enzyme. So by doing so it also kills any estrogen that was attached to that enzyme. That means when you stop using aromasin you won't rebound at all like you would with the binding AI's and if anything you will have to wait for a while for your body to start producing more aromatase (very bad if you crashed your estro comparing to the other AI's). Each person is different in the rate they create new aromatase. Only way you can speed up the process is by using HGH, you can use all the dbol you want, all the test suspension you want, if you crashed your estro with aromasin and you don't have aromataze. You wont even bloat from those compounds. There wont be any estrogen conversion.

Hands down the best for blasting but it does have its downsides. My own experience [ I found that the more I use aromasin the more sensitive I become to it. When starting out with aromasin even 25mg per day is a common dose for a mild cycle say 750mg test and 500mg deca. As time goes by the more I use it the less I will need, I end up needing 12.5mg eod if not less for a mild cycle. It doesn't happen in a few days though it takes months. ] This may not happen for you. It is based off my blood tests having the same amount of estro, but needing less stane to control it. Almost as if I would become sensitive to it. Another drawback of aromasin is hairloss, comparing to the other AI's I found it makes me shed a lot more. One side effect of aromasin is Alopecia, the other two AI's have hairloss/hair thinning as a side effect but not full blown Alopecia. So if your prone to Male Pattern Baldness be cautious.

The biggest fear with aromasin is crashing estro to low. At this point all you can do is wait or up your hgh dose. Give it at least 10 days before you start taking any more AI even if you are switching to Adex.

Exemestane, sold under the name Aromasin. by Pfizer, is an orally available suicidal aromatase inhibitor. <-- This sentence describes exactly why exemestane is the king of Anti-E's for bodybuilding purposes.

Because exemestane is steroidal this gives it a favorable estrogen suppression profile and confers a few really awesome benefits over other anti-estrogens both on paper and in real experience. Steroidal anti-estrogens have the benefit of being lipid-friendly and they all lower SHBG which increases the ratio of free to bound testosterone, which as many experienced BB'ers know can have a relatively profound positive impact on gains.

I think it is important to understand how drugs work in order to properly dose them, exemestane is a suicidal aromatase inhibitor, this means that it binds with aromatase enzymes and as it does so permanently disables the enzyme and destroys it. Hence the "suicidal" this chemical is like a kamikaze pilot out to destroy your aromatase enzymes which is what makes it so special.

Exemestane's half life in the male body is actually very short (~9 hours) and it is quickly eliminated, however, since as soon as it enters your bloodstream it quickly destroys 80-90% of the aromatase enzymes present in your body, it is effective in maintaining significant reductions in estrogen for up to 72 hours after a single 25mg dose. Estrogen levels only begin to rise again after your body has begun to make new aromatase enzymes to replace the ones destroyed by exemestane.

There is a study on the pharmacokinetics of exemestane in men which found the following:
-24 hours after one 25mg dose estrogen levels are reduced by 70-80%
-72 hours later estrogen levels are still 40% below baseline even though the drug itself is almost completely eliminated
-120 hours after initial dose estrogen levels return to baseline (without rebounding)

Thiss means that you can find the timing and dosage that works for you, I've seen some guys recommend between 25mg ED and 12.5mg e4d, and you can see why both are effective while providing different levels of estrogen suppression, and it is this flexibility that makes exemestane such a versatile Anti-E.

Aromasin is also a badass PCT drug! In males exemestane was found to increase total testosterone by ~60% after 10 days @ 25mg/day, however the same study found that while it increased total testosterone by 60% free testosterone was increased by over 100 percent! that's right, it DOUBLES bio-available testosterone (natty of course).

I can tell you this much, when I take aromasin for PCT the results are dramatic, honestly my Libido is never absent at any point during PCT and I absolutely feel great within a matter of days, and this is taking 12.5mg ED, the only side effect i notice is stiff joints and other stiff areas

the good:
-powerful aromatase inhibitor capable of stopping gynecomastia completely on its own (for aromatizing compounds)
-has powerful bloat-reduction effects
-lowers SHBG, increasing free test & makes all other anabolic steroids more bio-available
-can actually boost Libido on and off cycle
-increases IGF-1
-NO adverse changes in lipid profiles for men (granted if you are using it on cycle this may be different)
-is NOT liver toxic
-no estrogen rebound

the bad:
-typical aromatase inhibitor issues here include stiff joints and possibly lethargy
-more difficult to come by than a-dex or letro

Appropriate uses for Exemestane:

1) on cycle estrogen control - that's right, any and all estrogen related problems can and should be corrected with this compound, from gynecomastia to acne to bloat exemestane is a panacea, run it at 12.5mg e4d for gynecomastia protection and bloat control, or run it at 25mg ED for pre-contest or for gynecomastia sensitive individuals or moon face. the beauty of aromasin is it's okay to use preventatively and not just as spot treatment for gynecomastia as it doesn't hurt gains nearly to the degree that other Anti-E's do, I'd still recommend using Anti-E's only if you need them, but if you must use one throughout your cycle, you couldn't pick a better compound to use.

2) PCT. Aromasin is the premier PCT drug in my experience... it's a breeze compared to clomid/nolva and significantly better than a-dex (more powerful and fewer sides) it works excellently with HCG - human chorionic gonadotropin - and keeps the extra aromatization from the HCG - human chorionic gonadotropin - injects at bay (you can even run higher dosages of HCG - human chorionic gonadotropin - above 500iu/inject) and another bonus is since it's safe and comfortable to run for longer periods of time, you can stretch your PCT out to 6 or 8 weeks for suppressive cycles to make sure you get everything back in full working order

3) gynecomastia reversal - in conjunction with a selective estrogen receptor modulator (raloxifene or tamoxifen) and/or a dihydrotestosterone derived compound aromasin can be effective in reversing/reducing existing gynecomastia

4) off cycle testosterone boost - sometimes if I don't feel like running a cycle but still want a little extra kick I'll take 25mg EOD for 4-6 weeks, gains aren't improved all that greatly but significantly, but I do it more for the Libido/mental effects anyways.

5) hypogonadism - so you're getting older, you've been cycling since you were 21 and your natty test levels just never get back in the good range, but you don't wanna go HRT??? aromasin will get you back in the game without having to take the plunge for HRT.