+ 8 Sciroxx Aromadex trouble
Unfortunately I must warn the community about some problems I ran in to with Sciroxx aromasin.
They call it Aromadex and its dosed at 25 mg per pill, with 100 pills per pack . The batch number on my pack was 4537 . I had gotten this, Providex and Clenodex from Texxgears who I believe was an authorized distributor of Sciroxx, a name I thought I did not need to worry about.
Early June I began using 12.5 mg ED of the Aromadex, July 13 I had blood taken and on July 16 I got my number of 92.7 on Estradiol . I had been feeling kind of flat and my libido wasnt what I expected, plus my strength seemed off. When I got this blood work I decided to double my dose and take a full 25 mg ED , did that until August 8th when I got blood taken , the results for that last test show me now at 130.9 Estradiol , so I think its safe to say the product is garbage, which is where its going in the last pic, and I now have my answer as to why I felt this way. I have switched my brand of AI and will retest again in 1 month.
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I'm not sure why everyone is just eating everything that it written here without actually reading the article ?!
the Estradiol suppression on plasma levels was found to be 32 percent !
This is confirmed as well on this much more - http://www.ncbi.nlm.nih.gov/pubmed/14671195 which is also quoted on this article by megaT883.
what is more embarrassing is that MegaT883 who brought this article doesn't know to read either - the PEAK suppression was found to be 12 hours after administration (72 percents) but the average suppression under daily administration is 30-40 percents, which may also clearly explains the blood levels under so high testosterone serum levels
That is incorrect. Quoted from the study :The PK properties of the 25-mg dose showed the highest exemestane concentrations 1 h after administration, indicating rapid absorption. The terminal half-life was 8.9 h. Maximal estradiol suppression of 62 ± 14% was observed at 12 h. The drug was well tolerated. In conclusion, exemestane is a potent aromatase inhibitor in men and an alternative to the choice of available inhibitors.
I'm embarresed for Karl you see what he is stating is incorrect. This is what he is leaving out.."At the end of the 10 day study blood was draw 24 hrs later after the last dose and estradiol was at 38%." This is the exact quote from the long version : There were 38%, 71%, and 45% decreases in estradiol, estrone, and estrone sulfate concentrations, respectively, after 10 d, approximately 24 h after administration of the last dose of 25 mg exemestane, This makes sense since the half life is right at 9hrs and max suppresion is 62% is reached at 12 hr. It then drops to 38% at the 24hr mark.
This product did very little to suppress estradiol.I'm wondering if it was even Aromasin.There was another study done "The Effects of Injected Testosterone Dose and Age on the Conversion of Testosterone to Estradiol and Dihydrotestosterone in Young and Older Men" It shows how much testosterone converts to estradiol.Noviceass is closer to the Young age group at 43. This graph shows that estradiol was never over 100 in the up to 35yr olds even at 3500ng/dl of Testosterone. So no Karl it's your product. Fifty-one young (aged 19–35 yr) and 52 older (aged 59–75 yr) men were in the study. This was estradiol levels without an AI being given.
http://jcem.endojournals.org/content/88/12/5951.long
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2913038/figure/F2/
RustyhookerBecause it's a science based fact that 92 estradiol is DOUBLE the high level even though he used DOUBLE your product which more than proves yoyr extremely under dosing your tabs.
Raise the bar sir.
Well science based - if the test level are a DOZEN times higher then normal then you may expect 1.5 higher estradiol levels then normal
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2913038/figure/F2/
RustyhookerDozens of blood tests posted here at eroids show that aromasin from peptide companies dosed at 25Mg/day dropped dudes estro from 400+ to sub 40 in just a week. Yet, Sciroxx at 25/day and he's double the medically posted 40.
Why not tighten standards? Bring a pure product and move into the top 10. Business wise it's simple. Especially with your connections.
I'm responsible on the quality we release, not to one individual results under certain circumstances. Estradiol serum levels is quite intrigue issue. it's determined by many factors and it's quite difficult to learn from it conclusively on AI, especially when the one who posted these results is a fanboy of other source as everyone knows
What amazes me is that you got from me one product, you appreciated the quality, and I find u posting on any honest comment I put here after 5 minutes with such passion against Sciroxx,
should we wonder ?
RustyhookerPharma grade caber. P--H-A-R-M-A
NOT YOUR TOILETTE TABS
Karl. Saying things like hurts only you in the long run. The way you express your opinion ,
instead of saying - I'll look into why you got a mislabeled product to start with, and Ill find out why my product comes up short in your test. You accuse and then say something smart assed about the person who bothered to take the time to have your product tested. Instead of you going out and posting test's on your own.This in its self doesn't make you and your company look good...just a thought.
For those interested here is the complete study and I quote"The maximal suppression evoked by exemestane at the single dose of 25 mg in the present study was similar to published results in postmenopausal women, but the time course differed (24). Evans et al. (24) reported that a single 25-mg oral dose of exemestane maximally suppressed estradiol concentrations by 72% 3 d after administration, and estradiol levels returned to baseline only 8–11 d after drug administration. In the present study maximal suppression of estradiol of 62% was observed 12 h after exemestane administration and returned to baseline 3–6 d after administration.
http://jcem.endojournals.org/content/88/12/5951.long
AnonThank you, this is fantastic info when you get the whole article. Karl seems to like the edited version though
Give them a vote if you find it helpful.PermalinkNo problem Noviceaas . Just want to make you aware of another study "Effects of Injected Testosterone Dose and Age on the Conversion of Testosterone to Estradiol and Dihydrotestosterone in Young and Older Men". Basically the study shows that 19-35yr olds (11men) (since your 42 I would pay more attention to the younger numbers and add a few points)and 59-75yr olds (7men) the max estradiol converted on 600mg of Pharma Test E (Delatestryl) that was given for 20wks. With this info you can get a fair idea of where your estradiol levels will fall with the dose you used. Pay particular attention to figure1 and Figure2 of the study.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2913038/
AnonDamn thats some info right there. Thats going to take me a little while to absorb ;)
Selling shitty AI's are the single most screwed up thing you can do to somebody.... I guess it doesn't matter if your gear is bunk too... Who needs an AI with Wesson oil ? +1 novice. Good job.
These labs are the single greatest benefit to the user here. If you are interested in knowing what is working and what is not. Thank you for this! +2
StevebNot good
Wait a minute...... Hold the boat.... karlx is NOT going to draw his own blood and run a lab in Germany? And then vomit his swill here calling him a liar.... and bullshit artist? Oh, and wait... start a PM campaign to "back door" this user? Where is the justice? Where is the equity? See.. I had nothing to do with this... so apparently it means nothing.... This proves the point that he is crazier than a shit house rat....
Stupid in.... stupid out... nuff said.
RustyhookerSwill some of the new primo free. It's the cost of primo yet free of any traces of primo. Or should it be called Tren Lyte?
Oooooooh! Lol
AnonKarl your full of shit scroixxxx sucks ass not only bunk ass gear bunk ass ai as well
RustyhookerDamn! Sciroxx is flat falling out into gutter
BigBmajI was thinking about this today. It's almost worse to sell a bunk AI than anything else. Throwing some unwanted tits on a brother is a terrible crime.
I love all the testing that's going on these days. It's fantastic. Sources are going to be forced into selling decent product.
AnonFor the life of me I couldnt figure out why I felt like shit. I dont get puffy nipples easilly, so those obvious visible signs dont work. Its blood work or nothing for me , because Ive tried to guess before and thats just not a good idea.
I have the same problem. I'm not prone to gyno and my body is good at hiding bloat so another indicator I usually dont notice.
But if I start tearing up while watching tv I KNOW my estrogen is high! LoL
Anonlolol my wife likes that, it means Im all sensitive and sheet ;)
x2. Awww yea. Gotta give us hard working mofos what we paying for now. Lab tests are awesome on here.
100% with you. I can accept some fake oils, don't get me wrong.. I'll be pissed, but in the end I'll accept it and move on. But fake AI or any other ancillaries is the biggest dick-move in this business.
AnonTO EVERYONE OUT THERE READING THIS !!!
Those who know me know I am a man of my word, and I am not trying to destroy or boost anyones reputation. I am just doing my job as a member of this community to run the appropriate tests for my own safety and then share them with you.
In about 4 weeks time I will get another blood test. I have switched brands of AI and am going to run 25mg for two weeks, then drop down to 12.5 per day and re test. To be scientific about this I will be keeping my test dose the same . Stay tuned !
BigBmajWatch the joints running high like that. I got carried away the other day and now I feel like a 90 year old man. Everything hurts.
What AI are you now on?
AnonSwitched to Anabolic Nation Aromasin dosed at 12.5 per pill . Im only going to run double dose for 2 weeks to try and bring that number down. Ive run this amount of test before and been able to keep my estro at 28 so I expect to be able to do this now. As I ve said before we all will know in about 4 weeks
figures
Anonfigures ? Why did you want me to now try another dubious source for you ? I think if your estro was high youd want what you thought was one of the best too.
angusYour E2 is at 92 and you're gonna run 25mg of Aro every day for 2 weeks?! Just my opinion, but you are gonna flatline your estrogen.
AnonOK I'll take your advice and go a little easier, Ive just been getting no where the past month and wanted to make some headway .
agreed.. 25 ED is a good idea, but i wouldn't do it for 2 weeks. maybe 4-5 days, then drop back to 12.5 ED. watch for sides and readjust if needed. 92 is high, but it's not so high that an aggressive protocol is needed. if the asin Karl gave is some bullshit, then a good asin would/should knock it back into range at 12.5 ED for a couple weeks, possibly less. could always drop the test dose back for a couple weeks to help catch up quicker.
Anonits actually 131 now , but your right Ive certainly seen way worse. I just wanted to get back under control quickly. I didnt want to drop the test dose so thats why I figured Id hit it aggressively . Ive been spinning my wheels for a month now so just trying to catch up.
This product got straight from my lab if the delivery was done on ?March
I sent FR to get to the root of it.
I asked Texxgears to contact me about 2 weeks ago about these issues, and I still ask him to contact me
With what other products you combined the Aromasin ? before and after the tests.
Other products arrived with this Aromasin - I'll appreciate of you post your feedback or lab tests on them
AnonKarl I have accepted FR , and as I said Id be happy to help you in any way get to the bottom of this.
Novi, you're a true diplomat. I just don't think I could be so understanding in a situation like this.
As a note - the Estradiol levels matches the high test levels, and I'll specify -
Pls read this article - http://www.ncbi.nlm.nih.gov/pubmed/14671195 - Pharmacokinetics and dose finding of a potent aromatase inhibitor, aromasin (exemestane), in young males.
As you may learn there a dosage of 25mg of exemstane decreased Estradiol levels by 38 percents (and 50mg with 32 percents - anyhow it shows that an effective dosage of exemstane will decrease estradiol by 30-40 percents - there is statistically discrepencies as the clinical test was done on only 12 patients - if it would have done on 12,000 patients we would get much more accurate number between 30-40 percents). So as expected the Exemestane wouldn't decrease Estradiol levels by 98 percents or so as one may expect:) it's not formulated like this, and such outcome is certainly not welcome (without getting into the clinical effect of dropping that significantly the estradiol levels) - so if you expected while taking testosterone on superpharmacological levels to keep estradiol levels below 50 or even 100 with exemestane you were absolutely wrong,
Pls contact me - despite the fact that I don't even know you If there is any problem from any kind I'll always back up what I manufactured.
K
The 32% is misleading as that reading was taken 24hrs after the last dose.If you would have posted the complete study it would show that a single 25mg dose suppressed estradiol 62%"In the present study maximal suppression of estradiol of 62% was observed 12 h after exemestane administration and returned to baseline 3–6 d after administration." So it suppresses estradiol by 62% 12hrs after administration. For those who would like to verify what I'm saying is true I'll provide the link to the complete study scroll down 3/4 page to the header that says Discussion and read what is written 3rd paragraph.
http://jcem.endojournals.org/content/88/12/5951.long
You are so full of shit. You sold a bad product. Admit it.
Yes he is
Are you fucking kidding me. Flat out, blood test after blood test have shown that estrogen levels can be kept in normal ranges provided the ai used is properly dosed. They can even be crushed down to virtually zero. You're a jack ass scammer. You should be booted from here, or at the very least be given a troll tag. Your products are inferior and should be avoided.
Check my references to real science - with such high serum test levels thiese estradiol levels should be expected. this customer got 100 tabs - send 2 tabs to a real lab test.
I agree that estradiol levels may be reduced even to normal range, but you can't and should expect at serum test of ~6000 to get it, unless you do make some trial and error with higher level of or properly combination of anti estrogens.
in this case I assume thatt he product arrived from me, and very hard to fake any tabs anyhow so I take full responsibility, you may consider me as a jack ass scammer, but I back up the quality he got.
AnonI use 500-600mg of human grade (Sandoz, Watson, Pfizer) Test Cyp a week which relates to about 6000-7000 test levels; IM overly prone to gyno and 12.5mg of Pfizer Aromasin has kept my estrogen below 30, taking it 2-3 times a week.. You keep making more and more excuses bro, no way at the dose he was taking should his estrogen have been rising through the roof like that. If he submitted a pill to be tested, you would jump on saying the test is unreliable and someone is trying to ruin your already terrible reputation.
You don't use your own Test Cyp?
Dammm.. lol.. all faith is officially lost. Now waiting for my homie Mint opening on Monday so I can salvage my cycle from the shitter. Thanks for posting this Novi , peeps need to know.
AnonWatch out.. Karl is going to have a analytical chemist doctor who created chemistry verify that all his products are GMP certified and better than Pfizer.. stay tuned LOL