Great read on HGH info
http://jcem.endojournals.org/content/85/2/601.full
"Exogenous 20K Growth Hormone (GH) Suppresses Endogenous 22K GH Secretion in Normal Men" Y. Hashimoto et al. 2000
It is of special interest since the experiment was done on 32 HEALTHY adults aged 20-31.
OK, the key findings which contradicts much of the hype around hgh:
*Exogenous hgh administration (sc) will not supress endogenous hgh production before 4 hours after administartion.
*IGF levels will raise slowly in 12 hours after administartion and then raise rapidly and reach a peak about 24 hours after administration.
*Exogenous hgh administration will supress endogenous hgh prduction for about 24 hours. This did even occur at small doses of 1-2iu a day.
*HGH is very dose dependant. A 10iu dose will give a ten fold increase in peak concentration levels of both hgh and igf-1. Also a bigger dose will not increase the supression time or peak times.
In regard to timining of hgh injections this would mean that the best time to inject your hgh is just before you go to sleep. That way you will still get your largest endogenous pulse, which accours about 2 hours after you go to sleep, and when that pulse is over, a little later in about 4 hours your hgh levelse will reach another peak from the hgh administration. The supression of your own hgh will be finished by the time you do your next injection the day after at the same time, so you will still get the deep sleep pulse the night after.
By taking your shots am you will supress all endogenous production of hgh the following night. Forget thinking that going up taking your shot 4am or 7am will help you not supress your own production, you will be shut down for 24 hours.
By doing several injections each day like am/afternoon you will shut down your own production completely.
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I'm so confused! cocopuff please help lol
In the graphs it clearly shows suppression immediately following injection. Unless I am interpreting it wrong?
so if this is true it shouldn't matter what time we inject right?
another thing. If you look at the graphs, it shows 16 hours is about how long each injection takes to reach zero or bottom. So wouldn't injecting first thing in the morning be best because by the time you go to bed the injected exo hgh will have bottomed out and your big natural pulse from sleep will bring levels back up until your next injection? Just my random thoughts I do not know a right or wrong answer I'm hoping you can help explain
Cocopuffman idk either after EmPee came in here and said what he had said
also it says the injected HGH will suppress natural levels for like 18 hours so maybe injecting right before bed is the best way to get your natural pulse and prepare for the next day.
Since when do we inject 20K? Or maybe I'm missing something here?
Cocopuffobviously you are missing something.
Serum 20K- and 22K-hGH levels were monitored every 30 min for 24 h by specific enzyme-linked immunosorbent assays.
its the code for that certain type of serum I guess
Do you even know what 20K means?
Cocopuffit must be the code for the HGH? if you know what it means why did you ask about injecting 20k of hgh?
Obviously means you're pretty sure.
Now this shows you have no idea.
What I'm trying to tell you is that this study is about injecting 20K HGH. The products you buy and inject are 22K HGH. So you are trying to apply a study conducted specifically about 20K HGH, to 22K HGH. It doesn't work that way. They are different molecules. On what grounds are you assuming the outcome of the study would be the same? Hope I make sense to you now.
CocopuffSo you are injecting endogenous 22k HGH, how does this make any sense? unless the study is wrong?
if 22k is what your body is producing shouldn't the exo have a different code then?
22k is not the code brother. It is the molecular weight in Daltons.
Cocopuffso this study is not viable to follow by? is me injecting before bedtime so that my natural pulses are released before suppression not good to go?
From a scientific point of view, it is not viable to follow by since the molecule you are injecting, and the molecule that the study is based on, are different. As simple as that.
Whether the study gives the same results for 22k is a whole other story. I was just saying that based on this study, you cannot draw any conclusions.
At your age, I would inject first thing in the morning, early AM. That is one good option.
Hope I helped.
Cocopuffare any of you guys even looking at the charts in the link?
i guess what i dont get is think for a second. lets say using any exogenous gh supress natty production right so yes it do take 3-4 hrs for gh level to PEAK after injection doesnt mean its not active in your body. blood tests have shown this people that inect 2.5-3 hours after injections there blood levels still have significant amounts of gh more than what your natty pulse would be for sure. so i dont know, i would want to see blood tests proving this before i change my protoco. i saw awesome results 2 iu am and 2 iu pre wo and using prami at night. would love to see some evidence with bloods. if someone wanted to run a little experiement that would be awesome too! lets get some some gh vets in here.
blood tests are injected IM intramuscular. IM injections peak much sooner.
SC injections dont peak until 4 hours after injection
would love to see blood test provingthis. run one month at night do igf testing. then one month am and do igf.
Here again more contradictions about hgh!