I do not know much about E2 but i have been suffering from SEVERE migraines since i have been about 6 years old. By the time i was 8 i was already taking Imitrex injection quad shots. Of course i was 8 at the time so my father would put the little insulin needle in my quad. The injections were almost exactly like someone with an EPI pen but this had Imitrex in it.

Anyways migraines continued badly till about 14 and then started to go away. I would get an average of 6 natural one's a year. I say NATURAL because they would just naturally come on. Not counting migraines from drinking to much the night before etc....

As i got into my 20's i was getting maybe 3-4 a year but once i felt it coming would immediately take medication to avoid Migraine.

The reason i am going on like this is because when i first started running test i began to start getting Migraines again. As i raised test dosage i started getting multiple Migraines a day. It was awful. Then after a week or 2 they just stopped. My body had to adjust to the test levels.

Next cycle EQ and Test= Went through same thing that happened when i ran test in the beginning except Migraines became worse when EQ kicked in. But again after a week or so they stopped.

I contribute this to 1) High blood pressure. When you have high blood pressure your blood cells expand creating more blood flow throughout your body including your head of course. The way a migraine is killed or stopped is by the blood cells shrinking. That is why people take cold showers or blood pressure med's who suffer from migraines. It keeps it a bit better under control.2) Hydration- You need to consume a ton of water on gear in general but someone like myself must stay extremely hydrated at all times. Dehydration contributes badly to migraines.3) Food consumption. I have noticed when i am running all over the place and do not eat food after a few hours i start to get a migraine coming on.4) Stress- Bad stress also will compliment your migraine.
If you see all that i have listed above you can see i only listed just a few factors about migraines but those are the basic contributor's to migraine headaches.

Hope this way in some way helpful to you.

don't know about high e2 causing it but high blood presure definately can and will