shirlsguy's picture
shirlsguy
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Cabergoline alternative for Tren users on Anti-Depressants.

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I have been asked advice about a cycle with tren from someone who takes anti-depressants. My close friend crashes terribly on Cabergoline so I wondered about alternatives. Prami? My friend uses a version of formestant... I am sure it is a spray and I wondered if people know of this one? I think it is an AI, not a progesterone remedy, but I don't always know that much.

So.... those with experience with anti-depressants, what is the best option to Cabergoline?

RaW InStiNcTz's picture

What would be a proper dose for prami I was taking caber .25 weekly but it seems I miss placed it. I still have one bottle of caber left but was thinking of trying prami I heard good things my other concern would be since prami is liquid would it go bad? I won't be doing another cycle until April

mwagner630's picture

i wonder if bromo would be a a suitable alternative. i know its another agonist but the composition is slightly different than caber or or prami, seems it may also effect a few different receptors. i havent really researched bromo much. so i may be wrong. but it appears as though it does the same thing but a little different. maybe someone with more bromo knowledge can elaborate. sorry, im really sick and even using the noggin today is challenging.

j223's picture

prami is stronger than caber. If you have prolactin issues but don't want to take a dopamine agonist then I would suggest running an extremely low dose test and using an AI plus mast and proviron. Also he should be able to take a very low dose caber 0.25mg once per week it has a long half life. Unless it has some horrible interaction it should be okay but hard to say not knowing what AD he is on.

Doss's picture

just curious, but how does an AI and a DHT help with prolactin other than helping keep estro in check?

j223's picture

well high estrogen usually correlates with increase in prolactin. If estrogen is low to begin with prolactin will not get too high.

I'm not saying its perfect or ideal but it will definitely help.

On a side note caber doesn't interact with any antidepressants negatively there should be no problem taking it with AD's.

Doss's picture

this is true. it's been scientifically documented that elevate estrogen yields the precursors for prolactin. if the prolactin issues were solely estro-related, in the absence of a 19-nor, then i'd completely agree with the AI.

however, when we toss a 19-nor into the mix, we have a completely different stimulus for prolactin release. because of the interactions there, versus with estradiol, we now have to approach it from a different angle using an antagonist. since dopamine is an antagonist to prolactin, our dopamine agonists are able to take over when the issue stems beyond that of estrogen.

j223's picture

people can get high prolactin from test only. It's not common but it can happen

Doss's picture

Yes. I agree. From what I can see, it's due to unregulated estradiol, tho.

Doss's picture

i'm not familiar with formestant. prami could be a feasible alternative for him. basically, what you're trying to accomplish is to suppress prolactin levels thru a dopamine agonist. a quick excerpt for those that don't fully understand what that means:

An agonist is a chemical that binds to some receptor of a cell and triggers a response by that cell. Agonists often mimic the action of a naturally occurring substance. Whereas an agonist causes an action, an antagonist blocks the action of the agonist and an inverse agonist causes an action opposite to that of the agonist.

so, the dopamine agonist is a compound that binds to the receptors of the cells responsible for producing/releasing dopamine. because studies have proven that dopamine has a dose dependent suppressive effect against prolactin, any medication that illicits a rise in dopamine will suppress prolactin levels.

so, he needs to find a dope-ag that he can tolerate, since that is really the only option for regulating prolactin.