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How to control prolactin

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Alright here is a post I wrote up a while ago, I wanted to add it to this section.

Ok as we all know, steroids like deca/NPP and tren are progestins and are known to raise prolactin levels when ran with other steroids such as testosterone. These steroids: deca and tren are from the 19-nor testosterone family are recognized by the body as progestins. Progestins have the ability to increase prolactin levels. Prolactin is responsible for "deca dick" or puffy nipples (or even leaking nipples!) when running a cycle like this.

So in addition to running an AI like Arimidex or Aromasin to take care of estrogen, we must also run ancillaries to take care of prolactin. Our most common choices are Cabergoline, Bromocriptine, and Pramipexole. Typically Cabergoline is recommended since it is easy to dose and must only be taken once or 2x a week.

Pramipexole Pramipexole also known as mirapex, is a dopamine agonist similar to Cabergoline. It raises dopamine levels which lowers prolactin levels. Pramipexole is actually more effective in terms of prolactin supression. Prami is also low cost. Prami has many benefits in addition to prolactin suppression. Prami has been shown to increase GH levels by up to 300% (in normal healthy men)for 2 hours after dosing. Prami is also safe to use long term. Unlike Caber which can cause Cardiac and noncardiac fibrotic reactions.

Dosing:
The most important thing to know about Prami is you NEED to SLOWLY increase your dose. As slow as possible means more gradual change and less side effects. If done correctly you can have a very small amount of side effects or none at all.
Starting dose is typically 0.25mg, but if possible try half of this dose. So first few days do 0.125mg, after that if you have little to no bad sides, increase to 0.25mg.
For prolactin supression, 0.25mg ed is usually plenty, but you can go all the way up to 0.5mg if necessary.
Another thing is Prami is usually taken right at night about 1 hour before bedtime. This is because it can cause lethargy, which isn't a problem while you are sleeping. To get the GH benefits, you need to dose higher in the 1-2 mg range.

Cabergoline Cabergoline also known as dostinex or caber, is another dopamine agonist. It has a very long half life, so it can be taken once or twice a week. Unfortunately Caber can be expensive, but if you have the funds or if you get a good deal on it than it's worth it. Caber is also known to have low side effects in MOST people. (note caber is not stable in liquid form)

Dosing:
For your average cycle including test and about 400mg of deca, 0.25mg two times per week is usually enough to keep prolactin under control. If that is not enough you can bump up to three times per week or even 0.5mg two times per week. You really have to find what works for you but start low and adjust if necessary.
Give caber about 2-3 weeks to kick in before deciding the dosage needs to be changed.

Bromocriptine Bromocriptine also known as Parlodel is another dopamine agonist. I have not personally used this myself, but I will say that Bromo is another viable option to help reduce prolactin.
Bromo is known to be a little harsh on side effects, but some people tolerate it well. It is a little harder to find, but if you do bromo is very cheap.

Dosing:
Bromo dosages range from 1.25 to 15mg. It has a short half life so must be taken 2 or 3x a day.
For prolactin control You can start at 2.5mg per day by splitting one 2.5mg tablet and taken twice a day. If that is not enough bump up to 2.5mg twice per day.

Mars's picture

in response to the vitamin B6 - I did a quick google search and found these references -

Here are a few of many studies supporting the use of Vitamin B6 in reducing prolactin:

J Clin Endocrinol Metab 1976 Mar;42(3):603-6

Effect of pyridoxine on human hypophyseal trophic hormone release: a possible stimulation of hypothalamic dopaminergic pathway.

Delitala G, Masala A, Alagna S, Devilla L.

A single dose of pyridoxine (300 mg iv) produced significant rises in peak levels of immunoreactive growth hormone GH and significant decrease of plasma prolactin PRL in 8 hospitalized healthy subjects. Serum glucose, luteinizing hormone LH, follicle stimulating hormone FSH and thyrotropin TSH were not altered significantly. In addition, in 5 acromegalic patients who were studied with both L-dopa and pyridoxine, inhibition of GH secretion followed either agent in a similar pattern. These data suggest a hypothalamic dopaminergic effect of pyridoxine.

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N Engl J Med 1982 Aug 12;307(7):444-5

Pyridoxine (B6) suppresses the rise in prolactin and increases the rise in growth hormone induced by exercise.

Moretti C, Fabbri A, Gnessi L, Bonifacio V, Fraioli F, Isidori A.

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Boll Soc Ital Biol Sper 1984 Feb 28;60(2):273-8

[Influence of administration of pyridoxine on circadian rhythm of plasma ACTH, cortisol prolactin and somatotropin in normal subjects]

[Article in Italian]

Barletta C, Sellini M, Bartoli A, Bigi C, Buzzetti R, Giovannini C.

The influence of vitamin B6 in a dosage of 300 mg X 2 in 24 hrs, on circadian rhythm of plasmatic ACTH, cortisol, prolactin and somatotropin have been studied in 10 normal women. After vitamin B6 24 hrs pattern of ACTH and cortisol is unchanged; prolactin levels are slightly lower, in a statistically unsignificant proportion the night peak of growth hormone is higher in a statistically significant proportion (p. 0.05). The effect of vitamin B6 is likely to be mediated by dopaminergic receptors at hypothalamic level as previous studies by other Authors appear to prove.

Doss's picture

good read, bro

Catalyst's picture

Great addition to the group pages J223.

cj70052's picture

Awesome, good caber is hard to find due to cost.. Will have to start looking for some Prami for next Tren run

levelup's picture

great write up...you can also use b6 dosed 300mg 2 x a day. research shows it has great prolactin surpression at that dosage

Cheatnnature's picture

Very good! Lots of info!

P's picture

Nice write up, I like it.