+ 4 Anadrol gyno
Strange thing to be talking about but got into a discussion with another gym rat last night at the local watering hole during the football game about getting gyno while using adrol. Apparently it happened to him and he said the drol was to blame. I know some people claim it happens but this was a first to meet someone that actually claimed it happened. Went through the whole AI discussion about controlling estro but he said taking letro didn't do anything. I was also under the impression that controlling/crashing estro would have prevented the gyno, but apparently not. Now I had to do some research to see just what the hell could be going on.
Hopefully everyone using adrol knows that It is a DHT reduced steroid so basically it cannot convert to estradiol but from what I could gather from googling a bunch of stuff is that there seems to be a lot evidence stating that it has a direct binding affinity for the actual estrogen receptor itself which is very peculiar. This is what seems to be the mechanism of action for estro related side effects like gyno that drol apparently can produce. Since it has a direct effect on the estrogen receptors, no AI will help. I'll repeat that again....Since it has a direct effect on the estrogen receptors, no Aromatase inhibitor (AI) will help. The aromatase enzyme is not in play here so reducing it with an AI will have no effect since that mechanism is bypassed. The light finally switched on regarding what was happening here. So what do we do about it since gyno sucks but adrol is such an awesome compound???
Hmmm.....How about Nolva? Since lowering estro with an AI isn't going to do squat because the estro receptors themselves are being directly upregulated by the drol and not going through the normal pathway, it seems like maybe the best line of defense would be to block the estro receptors themselves in the target tissue. Bingo! Nolva!
Hopefully I am on the right track here so please correct me if I am off base with anything here but I think this is an important discussion for those rare few who seem to get gyno symptoms from drol and hopefully we can come to some final conclusion.
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These things can be tricky; but I think you're right on! Good detective work! +
The only time in my life I have started to get gyno was when I ran anadrol.... I mean in 15 years almost everytime I ran it boom symptoms of gyno would start never happened any other time.... +2 for the read
Have you tried running nolva with it?
No I did not
The biggest thing I learned last year from reading a few endocrinology books, was that even testosterone is an estrogen receptor agonist. The whole lock and key explanation for how receptors work is 100% flawed. It is goo acting on other goo. So, never say never because even the experts are learning all the time.
But.... this in mind, the affinity (speed to action/ability to invoke response) of a hormone in tissue, compared to another hormone in a tissue is the important thing. DHT's high action in the prostate tissues versus almost absent action in muscle tissue (again see binding affinities), for example.
But this said, you got to consider how gyno grows. DHT is not a part of the equation. And derivatives dont reduce to anything that is. (left hand side of the image is for gland growth...)
(https://www.ncbi.nlm.nih.gov/books/NBK279105/)
So, the question becomes, what is it's binding affinity for the estrogen receptor. It is not likely to be as high as estrogen, so estrogen will win every time. It is also unlikely that this has been documented in all too many studies.
So to answer the question, you would need to have case studies of people taking anadrol solo, or with TRT on people without and on people with gynecomastia, to see if it causes it, or (more quicker to see,,) if it aggravates it.
I can only say that; I have some gyno on my left hand side.
I have used 150mg test with up to 320mg anadrol (minimal change to LV's), for duration to 4 months approx.
It in no way whatsoever aggravated the existing gynecomastia... which truly needs minimal stimulation to show effect. (I am also a high aromatiser, and nothing of note there).
As far as I am concerned anadrol does not stimulate or cause gyno to any appreciable level in and of itself. Does it raise IGF? leaving otherthings to come to play as mapped in the image above, for example? Dunno, but not for me.
If I could only tolerate taking the stuff it would be a start lol...
I’ve seen the same thing in the limited literature that’s out there. I have pretty minor gyno, but drol definitely appears to flare it. Not sure how much nolvadex makes a difference but I take it anyways during and after pulses.
RustyhookerThere was a med link i posted about drol acting as a light switch. It doesnt convert .... but it turns on the estrogen receptors. The med link stated that science has yet to show which pathways. Maybe i can find those links.... Either route, i use nolva. It shuts off the e2 receptors. I would think that a cycle with mast/provi would also benefit.
Seems like your onto somthing for sure
Prolactin maybe?
I thought about prolactin but all the invivo research I was able to dig up showed adrol had no progesterone related activity so I ruled that out unless somebody has found something different.
Good to know, that was all I could think that possiblycould have been the problem.. That is weird