roidville007's picture
roidville007
  • 33
635

WHATS THE DIFFERENCE BETWEEN ESTRADIOL VS Estradiol, Ultrasensitive, LC/MS?

ad

I just got a blood work done. doing 1cc of cyp a week which is 250mg and 1cc of tren E which is 200mg. on my blood work testosterones is 2500 plus and estradiol came at 21 which is normal but estradiol, ultrasensitive, lc/ms came 158 which is way above the ref rage of 29pg/ml. can someone make sense of this? what it means and need to worried? also ALKALINE PHOSPHATASE is at 22 which is low. it supposed to be between 36-140 anyways everything else is fine and I have all the estrogen blocker in hand and so far no estro sides.

herktime's picture

too much biotin. you're fine. LCMS is labor intensive and cost intensive but accurate and reliable. The bioting is the real evil that takes most of the labs we get and puts them in junk science territory for any biotinylated strepdavidn sandwhich type of assay - most hormone and most small molecule and antigen, immune markers...wildly inconsistent, some up and some down, hundreds of device manufacturers and it's the cheapest and otherwise is very reliable. If more than the 30ug RDA is in your diet the interference is modest. the FDA warned abou this in 2017 and the assay kits just stopped quantifyin it...they cut the threshold for false or false positve results at 10% biotin in the draw. The CLIA and standardization for hormone reference range efforts are incentivizing cheaper assay designs and supposedly idiot proof to minimize technician and staffing costs. There's nothing to do but be consistent and emulate the same conditions as much as you can.

herktime's picture

Really? That's crazy. I think it's all walk science now. Have you seen the biotin interference for the majority of hypopituitary and immunological panel small molecules and antigens, peptides, hormones, etc? People get misdiagnosed and die fairly commonly.