posted Sun, 01/21/2024 - 04:50
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Looking at running mk677 on my last cycle but have seen alot of different dosing times. What's your guys experience. Is it better to us 25mg in the morning or at night. Personally I feel night before bed would be more beneficial due to go already secreting during sleep. What's your guys thoughts and experiences.
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I was think about the same thing for the ghrelin response.
Think the move is to cut a dose in half for the first week and then walk it up from there.
best of luck mate
Best advice I could give running this stuff for years is to titrate up your dose. If running 25mg tabs for example, start with a 1/4 a tab a day around the the time you sleep. Move it up a 1/4 tab a week every week. By the time you get to a whole tab the lethargy won't effect you. Also I tend to take it with melatonin at night so I can pass out before the ghrelin hits.
Do you not take advantage of the appetite increase?
I've been taking 12.5mg for 5 weeks now. I find if I take it in the morning I get lethargic about 2pm.
If I take it at night I sleep better but don't have any increase in appetite the next day.
So personally I take it between 2pm-5pm, I can eat more for last meal if needed, and I get to sleep better too
Is the lethargy quite tough to deal with? I was going to order some but if its one of those compounds that makes you feel tired and have to push to stay awake I won't bother. I really want the appetite increase from it but thats pointless if all I want to do is nap LOL
Ya I want to know too otherwise I'll take it before bed
Ya that would make it pointless for me too. I want it for the appetite also. But gh doesn’t make me tired so maybe mk won’t either, I’m hoping. I got some mk coming tomorrow, I’ll let you know what it does to me bud
When im tired (lazy) it just makes eating harder toward evenings. Especially last meal
I'm with you on that one mate, when you feel shattered all you want to do is go to bed and not think about sitting and getting a meal down you plus the pre-bedtime shake afterwards. But you know if you don't then you will of missed the opportunity and will potentially be burning up muscle while you sleep.
The lethargy is nothing compared to taking HGH in the morning. By 2pm I’m taking my preworkout and about to lift, so perhaps that’s why I didn’t feel too lethargic. If I take 2+IUs of HGH in the morning even with the 175mg of caffeine in my preworkout I could take a nap at 2pm. For reference, the only time I ingest caffeine is in my preworkout. Don’t drink coffee, tea, or energy drinks
I haven't had any major muscle injuries but I think it would be best for me to tune the joints up lol....a tune up!
I'm still on the fence about mk677. Not sure if I'll be interested in those other peptides.
So you take 2iu GH. What does that put your IGF1 score at? If you're at 300 that's pretty good for dose.
Never noticed much in the way healing injuries with mk. Your best bet would be to take BPC and tb500 for 4 weeks. Drop the box after and just continue the tb500 on minimal maintenance dose.
O yeah? Thanks for that info. Gotta do a lil preventive maintenance. Yea I've never gotten into these peptides. I wonder how much is this mk raising GH levels. Interesting but thanks man.
Seen many studies with peak gh almost 5-6x placebo at the first dose. Mk is an oral secretagogue. It increases your body's own gh response throughout the day.
Idk where it put me. I discontinued use before bloodwork because the finger numbness got unbearable. I jumped up to 4IU per day too quickly being an impatient jackass and the CTS symptoms hit me hard. Currently waiting to regain all feeling in my fingers before starting back up slowly and bumping up 0.5IU every 2-3 weeks.
Wow....all that torture for GH huh? Yeah the CTS and numbness is all I hear about. Supposedly the body will adapt. But like you said, it's a matter of taking it slow and not bumping up too fast.
I started at 2 iu and bumped it up by 1 every 5-7 days until i reached 6/day. A couple times i had a kind of uncomfortable feeling in my forearms when trying to go to sleep. It never lasted more than 2 nights in a row and i used an icy hot patch on the offending forearm to make it less noticeable. I've had experience with restless leg syndrome and this felt pretty similar though not as strong, at least in my case. I learned to either use icy hot patches or even better was to get medical gauze and wrap the limb pretty tightly. The idea is while the body can feel a ton of different sensations it's not very good at dealing with multiple sensations at the same time. You can still notice the uncomfortable feeling if you consciously pay attention to it. But if you have a stronger sensation over top of it and throw on a mindless something on tv you can just zone out to it can help you get some sleep.
Damn 6iu huh? Thanks for the details.
Supposedly the body adapts but that doesn't seem to be the case for some people.
In the next week or so I should have my test results back to see how far this has upped my igf1. I ended up at this dose as it was right in the middle of what Makwa suggested was the fun zone. Once i go back to just trt in a few weeks i'll probably drop it down to 3-4/day.
I mean at the end of the day advice is good no doubt but you have to find out what works best for you, you know? I would like to see your score. Good deal man.
6IU is the sweet spot Makwa preaches on here. Enough for hyperplasia but not so much to start needing to add other ancillaries to it
I got ya. I'm just not sure if I use it will be at 6iu. You still getting cts? Numbness? I'm familiar with the hormone itself, just haven't used it.
Subsided drastically. Stopped dosing completely for 7 days, took some dandelion root extract supplements, and peed out 8lb of water. Made me sad because I was 2# away from my bulking goal. I started back up last night at 2IU. Gonna stay there for 2ish weeks to see where things settle
You might be able to try going up .5 iu/week and see how that goes for you. If you said what you're prior increase schedule was i didn't catch it besides it being drastic. I was pretty wary about going up too fast myself. I intended to start at 1 iu/week and move up .5/week. Makwa convinced me to start @ 2 and go from there. PhinsFan81 also helped me work through my dosing increases and it turned out pretty well up to this point. They quickness of my recovery even at 2-3 iu was surprising. Didn't matter how hard i worked out those muscles would be mildly sore the next day and not sore at all the following day.
I immediately started off at 1/3 vial every night. So 3.33IU. Then went full yolo and added another 3.33IU in the AM before fasted cardio. We’re all allowed to be an idiot every once in a while. That was my moment. I said 4IU above. My math was wrong. It was definitely 3.33. I added 0.6ml to a vial and did 0.2ml per inject
Doubling the dosage was probably a bit aggressive. Both the people i talked with said to start splitting the dose after you pass 3 iu/day. Lots of folks have reported less negative side effects even at the same total daily dose this way. I do 3 2 iu shots daily. 1 first thing in the morning, 1 after i get home from work in the afternoon and 1 before bed. At the same time a lot of folks just say timing/dosing isn't as important as just getting it in you. If you want to do 1 big dose maybe start by splitting it and slowly migrate from being equal doses to one being bigger until you end up with it all in one.
Yea after the CTS hit me I started doing 2IU in the morning and 2IU at night to try and lower the dose, but the numbness had already got too bad at that point. Maybe it woulda went away while still dosing that way? I decided to just stop completely and restart the smart way.
Good decision
That sounds like the smarter way to me. It sound like the negative effects will go away eventually if you just keep pushing on long enough. But who wants to deal with all that bs for possibly weeks on end?
I agree. You got that right.
That sounds like a good starting point. Thanks for that bit of info. Keep us updated brother.
It made me feel so good. Could go outside and dunk all day on concrete like when I was 20 and feel refreshed the next day. And that’s after ACL reconstruction surgery when I was 30. So I will absolutely be hopping back on that wagon once I can. Just gotta play it smart and patient next time.
Damn got ya jumping around like Jordan huh? Yea as we get older things change but glad you're turning back that clock.
Have you ever had any experience with YK-11 or LGD 4033 mate?
No experience with HGH, if I ever decide what should my cycle look like to start? Also sent you a FR, interested in the AA group, I have 3 years sober and would like to keep it that way one day at a time.
Nope sorry. Just MK677 and MK2866 (ostarine)
It's not unmanageable, but again I'm only taking 12.5mg, mostly because I got 60 capsules, and rather take 12.5 for 60 days, rather than 25mg for 30 days (also I don't take it on days I don't goto the gym) but for me taking it at about 3pm no lethargy.
I think it will be because by that time you have a good amount of food in you to deal with the rise in IGF-1 levels and Blood Sugar decrease. I find taking orals like Adrol and DBol much easier later on after a few servings of food. From what I have read ideally its supposed to be 25mg in one go for the best results.
My next bulk I'll probably run 25mg, for 5 weeks, since I already don't take it once a week on rest day. You're probably on to something with that analysis. I know I'm most hungry the 1st 2 hours after taking it. I also don't like taking it anywhere near the same time as I take pre-workout, I feel like the caffeine still suppresses my hunger on MK, again only 12.5mg though. The more I'm talking about it. I should have just run 25mg lol
I tried it both morning and night. What’s your goal? Weight gain or weight loss? Take it right before bed if you’re limiting caloric intake. Otherwise, take it in the morning. It made me capable of eating an entire cheesecake in one sitting (not saying I did that lol but I could have). So great if you’re trying to bulk and struggling putting food down. As far as GH or igf levels you aren’t gonna notice or “feel” a major difference, so timing won’t matter in that regard. I started actually noticing those things taking supra-physiological doses of real HGH.
I'll be using it on my bulk cycle. Figured I'd use it for the growth effects and the appetite increase side effects since I have a hard time eating to grow. I can maintain and do deficit but increasing food is like a fat guy running a marathon lol.
I've been doing that. The morning dose causes crazy lethargy. Been a month. Yesterday I skipped the morning dose cause I had a pac test. Didn't want lethargy. I Felt a lot better. 25 mg am and pm. Might just do 50mg at night now. Or dose it down.
Then I personally would do it in the morning. The benefits you’ll get from the appetite/putting more food down while on a cycle will far outweigh the benefits from a slightly higher GH pulse at night in your sleep.
Would there be any benefit taking half in the morning and half at night
You'd be less lethargic, but ghrelin release will cause you to over eat very easily on this stuff.
Brilliant - thats what I'm hoping Lol @Mac12769 Thought you may be interested in this too mate.
I’ve thought about it for the appetite thing, just haven’t looked into just yet……but thanks for mentioning
I should have it in 2 days time so will give my verdict on it lol
Let me know. The EQ I’m running really boosted my appetite about week or so ago, so I’m pretty good now. But could be an off cycle /TRT option maybe to test with.