To clear up the sleep patterns and timing of dose (as well as this mystery hormone can be fully elucidated by anyone), 58-60% of your 24 hour GH release comes at the onset of sleep. Looking at the rest as an ultradian rhythm, GH is adaptable and difficult to rely on how it does so and when. But if you suppress the big nightly surge your body will quickly, if not somewhat randomly, account for the balance by increasing the daily pulses in various styles; so you may have three extra large daytime pulses or 5 moderate increases. I’m sure this hasn’t been tested against those replacing the hormone at night, but it’s reasonably clear that it does have to do with when you pulse melatonin at night (usually hour 21 of a 24 hour clock, but more adaptable than hGH so it can be said to blunt the GH surge or, alternatively, blunt the next pulse from ending in an exaggerated response to feedback of GH released around or after melatonin but then undergoing the longest pause in the 24 hour surge. If 60% were always fed back as a “holy shit we’re depleted” the daily pulses would be equitable in response. They seem to have a blank slate in the waking hours and do enough to keep the body’s background resources working on rest and repair, but any activity in the sympathetic nervous system will surely interrupt that as the body ramps up resources for use in the moment and one in the chamber. This stress ain’t bad. Usually cortisol and enough hormones signaling intense stress will get us to stop what we’re doing and if we’re lucky the subsequent acetylcholine released about 15 minutes after the challenge becomes too stressful but we pull through then stop with that extra bit of effort, the neurons will be traced and ready to encode that during sleep later that night. Unless you push too hard and dampen your brain with stress hormones. Typically, hard workload as assessed by the nervous system will peak at 45-60 minutes and a short window of time where testosterone peaks and gH pulses as well a short time later. So, together, the higher motor neurons will be recruited to the specific muscle targeted and make it increasingly easy to grow and improve control of its movement in isolation with just a flex of individual muscles. These are more and more in your control with many activities and lots of us therefore can get better muscle in certain areas but have problem areas. During the day you may not feel much from gH and shouldn’t really, but the sleep is an exception as it’s our time to splurge and let out over half the day’s GH in one sleep that we plan to reinforce the neuronal real estate dedicated to responding to stress of the muscle we challenged, pushed past its comfort for 15 minutes and then calmed ourselves with protein and simple carbs post workout, deep parasympathetic breathing exercises, etc. Leave the name out of it and HGH is truly a conductor of the circadian and ultradian rhythms of the immune and stress system. It doesn’t need to be around long to cascade effects. But neuropsychological feelings of well-being or “quality of life” and thriving are seen clinically by a year or not at all. The first few months are usually to see how you react, take pituitary MRI, and measure blood glucose. If all is set there you’ll get six months on standard dose and a check in with the likelihood of a dose increase if you say the right things and don’t look prediabetic. That’s at the nine month mark and the 12 month mark is their determination of whether it’s worth it based on the subjective rating scale

I’m sure people who get better sleep from hgh or anything feel tons better mood and vigor wise. But hGh takes a long time to influence real systemic change. The mechanisms are immediate but don’t alter your natural stasis and energy management plan during non GH periods for a bit of time. Still, combining with intermittent or time restricted eating will potentiate this and a couple months could make the effects visible. Hair and nails improve, but that’s not easy to get wrong. Simpler autocrine and paracrine effects from downstream processes. I’m not all that sure it does much unless you’re taking it empty stomach and working out then eating. Ideally you’d take some IGF-1 after workout during meal and dose another little IU of hgh about 180 minutes after eating at most to nap for 90 minutes. This tends to bring on two full recovery at rest periods but the second is focused on the stress and damage needing repair and neuronal motor recruiting and wiring primarily. The body also wakes up having release glucose thirty minutes prior to waking and cortisol in some amount as well. This presumably wakes you ready to go. It can be good to start your day fasted, rested, calm in the mind, and on an empty stomach get your bigger hgh dose in then work out hard, eat, spend 180 minutes doing daily routine - active constantly but lightly so (fidgeting throughout the day burns more calories than a 30 minute run). You’ll get a few things done, be digested, take an afternoon booster of hgh and nap for a full REM cycle. Wake up and be 90 minutes behind but be 90 times more alert and capable. Finish your work and then do some light cardio on the way to the gym or a class or some alternate workout if you like. Beast on a meal after that and give yourself a bit of relaxation then go for a long distance night run or sprints down the street. Workout with gymnastics type body movements or something like this that you can feel creative and will shock your nervous system. Don’t over do the third workout and have some small meal or protein with tons of water when you get back. Calm your body with breathing, showering, and get in bed. You’ll feel better and look better quick. Is it the hgh? Yeah if you can pull out three solid workouts and lose a meal in the day but keep your intake up later as you wish. It’s gonna be noticeable for the work you do and diet you have, but too many people want to recover better but don’t work out more. It’s not terrible, it’s a misunderstood hormone nobody quite gets completely. But you’ll have your own body to observe and that can be beneficial in its own right. Adjust accordingly. Dose in a way that you can be consistent and stick it out for the long term. I’m clinically on it as replacement after brain injury and it took me about a month or two to look shredded as cheese with a good diet and timing doses during fasted state. That was just 1.5 or 2IU I think at the time. I don’t usually do pharmacy hgh more than I’m prescribed but this year I might try it. I’ll go to 4 for some cycles but find it aggravates old elbow injuries to the degree I’m sure it’s turned to an immune response bordering arthritis. Ankle too. Obviously other factors played in here but don’t half ass this product or take it so nonchalant. You’re changing most every process of the body and that might or might not do something you notice, and the notice may be less than desirable. Of course, I don’t care I love the stuff. Took me a year before I noticed the stubborn little cognitive weakness and deficits that were plaguing my complete return to social and work life seemed less unreliable and I just felt more aware and in motion. I reached out to people more, had my old personality come back some, felt positive about things I knew were not positive because I felt some restorative resilience build up. Hard to describe but a life saver for me.

Does anyone’s sleep get worse? Within a few days my sleep pattern is worse.

I see the swelling and water retention on Serostim by day 4. But I use 6-7 IU's a day pharma grade 5 or 6 days a week. Increased recovery I start noticing in a few weeks. Fat loss just depends on how good my diet is. I used to be able to eat anything I wanted on HGH in my 20's and lose fat while putting on muscle. Now in my mid 30's, and I have to diet to see it quicker.

I use pharma grade HGH and I notice changes within the 1st week and they progress over time. My sleep, skin, hair, nails and recovery are the most noticeable quickly.

I really feel it after 12-16 weeks.

I noticed better sleep immediately. 2 months I noticed reduction in body fat. After three months I noticed an improvement with my skin.

It takes months with HGH to see the benefits physically .

The better sleep starts immediately , but the recomp effects promised in the advertisements takes 3-6 months minimum along with diet and exercise of course .

If your looking for actual increases of muscle and frame size you need to run HGH pretty high , too high honestly for me . And your talking about some serious serious money to get these effects out of HGH and you need to run other things while running HGH that high, to counteract the sides HGH causes at such levels.

I've never ran over 4iu's daily.

Better sleep from day 1 for me. I've always been a light sleeper but since being on GH I sleep deep and throughout the night. I can't really pin point when all the other stuff started occuring. I've been on for 46 days. started at 2iu and worked up to 5iu. Currently sitting at 4iu. In those 46 days though, I have definitely noticed an increase in hair and nail growth. Better energy throughout the day. Skin feels "tighter". I still feel sore from workouts but my body doesn't hurt as bad first thing in the morning (knees, ankles, etc.) My wife tells me I look leaner and I feel leaner. Glad I discovered GH.

Same here on the sleep it seemed like from day one i would get incredible sleep. My whole life I've had problems staying asleep getting to sleep and waking up without felling like shit i wish the would prescribe low dose of hgh for people with insomnia