Thyroid..
I have been doing quite a bit of research looking at how thyroid relates to the use of HGH and most importantly how to achieve optimal thyroid function. The conversion of T4 to T3 is a critical to ensure that the HGH thyroid loop functions optimally (in other words, you are not pissing away that expensive HGH you just got). There are several things that can interfere with the T4 conversion. Just as aside, don't think that you can avoid this issue by just taking T3 because it has been shown in studies that it is the conversion process itself not simply the T3 that is critical to the loop.
These things range from nutrient deficiencies, diet, medications, and other lifestyle habits. For example, taking a multi vitamin that has been clinically shown to be absorbed and utilized is critical. Lack of chromium, copper, iodine, selenium, zinc, vitamins A, B2, B6, and B12 all interfere with the conversion from T4 to T3. Additionally, medications such as beta blockers, Birth Control, synthetic estrogen, lithium, Phenytoin, and Theophylline can also block the thyroid conversion. As critical as diet can be to the use of aas, it also can be critical to the use of HGH. Soy products and cruciferous vegetables can also block the conversion. Soy much more so than the vegetables. Other agents that can block the T4 conversion include smoking, alcohol, intake of too much alpha lipoic acid, chronic stress, chronic illness, aging, and interestingly enough a HGH deficiency.
Another issue that is often not addressed is the use of a bioidentical source of T4. Bio identicals are more readily processed by the body. The ability to convert T4 to T3 is increased through the use of a bio identical thyroid. Ctyomel is often used with one caveat. (note that Ctyomel is a snythetic version of T4) Cytomel contains sucrose as a binder. Which has been known to cause spikes in blood sugar.
The point of all this is to say that simply taking HGH isn't going to make you the next mr/ms olympia. There is a lot more information that is necessary and relevant to succeeding than simply finding a "good" source for your HGH. Having the best HGH in the world isn't going to do a bit of good unless you have ancillaries necessary to support what you are doing. It is like injecting yourself with test, popping some d -bols and then expecting to get "big" while sitting on your butt.
- I am in no way advocating the use of HGH or supplementing with Thyroid. This is for informational purposes only.
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Great post, and good points by everyone. Thought about messing with t4 as i recently started growth, but talked to inspector, he talked some since into me... I am young, and this is my first time use with GH. Should get good enough gains off of it and should help reach some goals of mine. Currently packing on some bloat, feel as though its from the GH but it is only end of week 1. Any clues experts of growth? haha
AnonGlad you listen to folks...-).. I can tell you that goth and I experienced bloat in the second week of our cycle on growth..nothing crazy just some extra water weight. I will have to defer to Tread the resident expert on G..
Yea Inspector and Tread = GH Pros around here haha. Im always open ears you know, advice is appreciated when its from a good source. Hah the water weight is also from a test and deca combo Im using. But i really noticed it when I started GH. I will wake up in the morning with very minimal bloat. PIN my GH and over the day the bloat just occurs. Curious what 3 IUS will be like next week : )
GOOD WRITE UP!!! i got something out of it that i didnt know before so thats great. help at least one with sharing your knowledge and you have done your job. thanks. if i could give you a point i would but i stayed a peon before they took the toy button away.
Anonyour welcome and no worries about points.. if you can get something from it that is what counts.
Copied and pasted from another forum :
"Growth Hormone can, under some circumstances influence circulating concentrations of thyroxine (T4) and triiodothyronine (T3). Predominantly it would seem that the administration of GH increases the circulating concentrations of T3 while decreasing those of T4. This would suggest that GH is not affecting thyroidal secretion of T4 and T3 but rather influencing peripheral 5- and or 5' -monodeiodinase activity and the metabolism of the thyroid hormones and hence conversion of T4 to T3 (the active form of thyroid hormone). The major area for the production of circulating T3 is predominantly the liver but other organs (e.g. kidney) also participate.
There is evidence that GH can exert an accute effect on the metabolism of T4 to T3. GH administration to hGH-deficient children is followed by increased circulating concentrations of T3 but decreased concentrations of T4. Recombinant hGH similarly increases plasma T3 levels in normal adult men and women. This is consistent with GH enhancing 5'-monodeidination." - p. 424, Growth Hormone, Stephen Harvey
Thyroid function though is stimulated by GH and thyroid hormones and may provide either stimulatory or inhibitory feedback on GH secretion.
IF your output is low and replacement amounts of thyroid hormones are given at physiological levels, then this rapidly increases GH synthesis and GH content in hypothyroid animals. In these under thyroid states, the blunted release of GH to insulin, arginine and GHRH is reversed by thyroid hormone replacement.
However supplementing thyroid hormone in normal states above normalcy will directly inhibit base and GHRH-induced GH release from human pituitary cells and suppress transcription of the human GH gene.
Why do supra-normal amounts inhibit GH release? The explanation in part is that the introduction of IGF-1 synthesis in peripheral, pituitary or CNS tissue brings on this inhibition. In addition, thyroid hormones inhibit GH secretion by increasing inhibitory hypothalmic tone...think increased somatostatin release... in addition, a decrease of GHRH synthesis occurs in the hypothalamus.
One further note... glucocorticoid actions at the pituitary level tend to be stimulatory rather then inhibitory of GH. That is why a little release is beneficial to most people who are not extra sensitive to cortisol.
AnonThis is all about balancing the feedback loop...too much of one thing or the other in almost all feedback loops inhibit the production or release of whatever it is you are discussing. Thyroid and HGH have this type of relationship and both influence the other. It has been shown clinically that people with low thyroid often have low levels of HGH. The issue is the chicken or the egg. Did low levels of thyroid lead to low levels of HGH or vice versa.
tread-mYou make my brain hurt, but I'm a pain kinda guy so nice post! I have a link I send people to for this very conversation but now I can send them here, lot of good information! I'd give you a thumbs up but......I got no thumbs!
Anonno but it looks like you got a helpful button a cool button and a funny button... just no thumbs..