+ 2 Generic Gh=RHR study
I received some non fda approved (generic) Gh from a trusted sourced a couple weeks back. After a few days my resting heart rate elevated by 50%, from 55/60 to 88 beats per minute on 3.33iu per day. I’ve scoured the internet for studies on why and what the correlation was from. My research was inconclusive, however, every study I found showed that Pharmaceutical grade FDA Approved gh does NOT do this.
Here’s one example where subjects were given 9iu per day and after 4 weeks their heart rate was only elevated by 1 beat per minute, and 18iu per day only elevated by 5 beats per minute.
https://academic.oup.com/jcem/article/87/4/1654/2374961
So, because this isn’t the first time generics have done this to me and many others, does anyone know why? Again, Norditropin/Genotropin does not do this.
My bodyweight increase was 5lbs or 2%. Definitely not justify a 50% increase. 3 days off the generics and my heart rate is back down.
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Sparta showed me this link in another thread. My heart rate started increasing when I raised my Saizen dosage. I worked up to 4.5iu. I finished my Saizen and started using my Humatrope. My heart rate was still elevated. I think that gh raises my estrogen. I started feeling a little tenderness under my right nipple where I get a lump if my estrogen is high. I took 25mg of aromasin Tuesday and 25mg this morning. Yesterday my RHR was 99bpm. It was 71bpm while I slept. My RHR has been in the 90's for a few weeks. Today my RHR is at 79bpm. I have finished my Humatrope and I am using a generic now.
Update: I’ve been off all generic Hgh for a few weeks now. I have not been running any growth, just some IM IGF-1 pre workout. My resting heart rate has dropped 13 bpm from the mid 80s to the low 70s. No other changes were made that would contribute to that as far as I know
Bingo
I've just started back on, I’ll keep an eye on my rhr and update again. It’s concerning to me because I have a shit ton of generic growth and was looking forward to an extended run, one that I could never afford with 1st world pharma grade
Bacteria, impurities or something like that would be my guess. As long as it’s 100% verified that pharma doesn’t cause it, because basically that means pure hgh alone isn’t causing it. If you were to inject something IV that has bacteria in it you can feel your heart rate spike immediately
Also i wan't to add that Genotropin(pharma) and Godtropin(so called generic) gives me the exact effects and side effects.
I’ve repeatedly, well twice, had the same exact effects and side effects with godtropin as I would injecting Evian. Least I know the Evian source and that it’s good for me.
Your Genotropin must have been fake. If you read the study above, Genotropin was used, wherein very little rate heart elevation occurred.
Besides i didn't even say that Genotropin increased my heart rate. I said Genotropin and Godtropin both work the same for me.
"The clinical and hormonal characteristics of the study population at baseline and after 4 wk of treatment are shown in Table 1. There were 25 subjects in the placebo group, 17 in the low-, and 18 in the high-GH group. In Table 2, all side effects are reported. Overall, 46% of the subjects in the active treatment group had side effects, compared with 12% in the placebo group. Specifically, 7 of 17 subjects enrolled in the low-dose group had side effects during the study, and the dose was reduced in one, while in the high-dose group 9 of 18 subjects had side effects and two reduced the dose. In the placebo group, three subjects had side effects. Among these, one subject reduced the dose, and one subject stopped treatment at day 14 because of headache and tachycardia. The most frequently reported side effect was transient fluid retention. Increased sweating and arthralgia were also reported."
If you actually read it the high dose group had two participants reducing the dose because of headache and tachyhardia. Notice also how all the participants were in good health meaning they didn't suffer from hypothyroidism or other disease. GH at 2IU a day gives me hyperthyroidism if i increase my levothyroxin dose. I mean it's a very well known effect of GH that it burns through your thyroxine storages by increasing the convertion of T4 to T3. So a higher dose if GH doesn't necessarily lead to a higher metabolic state. This is dependent on your thyroxine levels. If my levothyroxine dose is too small then i will have symptoms of hypothyroidism whether my GH dose is 2IU or 20IU a day.
High T3 levels mate. The GH is doing exactly what is supposed to do and seemingly you have very good thyroid function if your metabolism is that high without supplementing with levothyroxine. I would simply reduce the dose to 2IU and see how you are feeling. There is no good reason to overdose HGH. Even 2IU dose gives me symptoms of hypothyroidism unless i take it with levothyroxine.
Thanks for commenting, however, your assumption is flawed. The aforementioned study above shows that pharmaceutical Gh does NOT do this. If elevated T3 levels was the case for increased heart rate, it would have done it to the subjects taking 9iu per day and 18iu per day. It did not, thus, we cannot conclude this is the case.
You are once again making an assumption that everyone reacts the same way to the rHGH regardless of their health status. DO you really think someone with hypothyroidism would improve their metabolism unless their dosage is increased? You know that extra thyroxine for the sped up T4 to T3 conversion rate has to come somewhere.
Besides, whatever "growth hormone" you are buying from the internet is either growth hormone or its not. It either is or not. Fillers are another question or impurities. These impurities could or could not increase your heart rate. However we know that GH increases the conversion of T4 into the active T3 hormone. T3 happens to control your heart rate and thus your metabolism.If your thyroid can keep up producing enough T4 to convert into T3 then your metabolism simply speeds up. But this is not always the case. There are plenty of studies on growth hormone where some invidivuals would enter into a hypothyroid state with rHGH treatment. This study im linking below is just one of the many existing ones: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8618596/
9IU dose would not raise my metabolism to that level. In fact it would make me feel tired as hell all the time. I am prone to hypothyroidism. It does not apply to every individual. Some people are hypothyroid by default by their genetics. You should not assume that everyone are on the same fitness level. In my opinion this study is very flawed and does not take genetics into consideration.
Thank you for your opinion.
No way. I’ve been trying to figure out why my RHR has gotten away from me, for what I believed to be no good reason. I’ve running lots of generics at higher dosages.