posted Sat, 09/08/2012 - 12:32
9189
AICAR dosing protocol
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I have researched and came up with a huge variance in how people are dosing this peptide. I am running it with GW501516 and Helios right now to obtain a synergistic effect. I was thinking of dosing it at 10mg ED or 20mg EOD. I have heard of using 100mg EOD which would make it more expensive than the RIPS I am also running. If anyone has any useful info it would be helpful. My stats are in my profile if you need them.
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Aicar is a peptide that is very interesting to me and I think the research I’ve done may help you a lot.
First of all a bit of its chemistry and history: Aicar is a modified form of AMP or adenosine monophosphate, we all know what adenosine triphosphate is (ATP), AMP is produced when an ATP molecule has lost 2 of its 3 phosphate ions so AMP is really the low energy state of ATP. Usually the body only breaks down ATP to ADP (adenosine diphosphate) and then adds an extra phosphate ion to that in the mitochondria where fats, carbs, proteins and ketones are oxidised. When you’re exercising heavily however your cells are forced to further use energy from the ADP molecules to make AMP. This tells the cell it is in a low energy state and needs more food so that’s where AMPK comes in, AMPK (adenosine monophosphate dependant protein kinase) has whole myriad of functions which I won’t bore you with here but basically it controls the energy level of the cell. By activating AMPK in your body your cells start breaking down fats and lipids to produce more ATP to bring the cell back to a normal energy state. Aicar works by tricking this mechanism into thinking it’s in a low energy state when it isn’t boosting ATP production and everything else associated with AMPK which is why it would have such a profound effect on endurance.
Dosing: Aicar would probably need to be dosed a lot higher than other peptides like you ghrelin mimetic and other hormone releasing agonists, the reason for this is the fact that Aicar affects every single cell it encounters. The other peptides mentioned only effect very specific receptors in specific parts of your body so the dosage is much much lower. Aicar isn’t to my knowledge in the human stage of testing so the studies at the moment are limited to rats and mice. There are 3 relevant studies. The first where they found that Aicar increased the endurance of untrained mice by 44% this Proves that AIcar can dramatically improve performance over a 4 week period, you should know though that the dosage was 500mg PER KILOGRAM!! PER DAY! That would translate into a couple of grams per day for us. The second study I found was the use of Aicar to prevent fualty gene related death by hyperthermia (overheating) and there they used 600mg/kg per day! The third study which was on its impact on obesity they used 100-500mg/KG per day.
These studies show two things, the first being that AICAR works and the second being that the doses needed are insanely high. Perhaps the same results could be achieved with less over a longer period of time but if I were you I’d take as much as I could reasonable afford or look at another chem. Let me know how you go. It will be interesting to see if you get any noticeable results on a much lower dosage. If you'd like I can look at the studies where it's been combined with GW501516 as that may reduce the amount but I think it's still very high.
I know all of this is a bit of a downer but I hope it helps, for what it’s worth.
1st study : http://www.ncbi.nlm.nih.gov/pubmed/18674809
2nd: http://www.nature.com/nm/journal/v18/n2/full/nm.2598.html?WT.ec_id=NM-20...
3rd: http://www.nutritionandmetabolism.com/content/3/1/31
Great response nerd. +1
Thanks for well written reply! I am not sure I can afford the amount it would take to make a difference. It would make it more expensive than my RIPS! LOL
I'm sorry it wasn't more positive, let us know how you go on the reduced dosage, from the sounds of the studies the effects should be cumulative so over time you might get some benefit from it especially mixed with GW. once these drugs are actually approved and used in mainstream medicine they should come down in cost as I can't imagine Aicar being too expensive to produce as it's a fairly simple molecule compared to true peptides. Anyway good luck mate.
Yeah. I am currently running 2.5iu of RIPS, 10mg AICAR, .25cc Helios, 5mg GW, 50mg of nandrogel, 12.5mg EOD Aromasin,.5 bi-weekly caber, and a weekly TRT dose of Test to counteract any nandro sides. I haven't really felt much of a difference except for where my injured elbow and shoulder are concerned. I have almost completely repaired my shoulder injury using the RIPS, and my elbow (chronic radial head fracture with floating cartlidge fragments) is getting nandrogel therapy to lube the joint. The helios definately gives a big speedy and thermogenic feel, but I haven't really noticed any huge spot reductions in the areas I inject. The GW is suspended in what tastes like moonshine which sucks to take in the morning along with the other compounds.
ive been scrolling through the peptide forum and there just isnt any good info out there on peps.. i have some interest in AIcAR and would luv to hear how your results are on this substance.. give up the dosage u used/using and how long.. keep this thread posted as much as possible.. id appreciate it.. thanks Odin
I am doing 10mg ed of AICAR along with .25cc of Helios and 5mg of GW501516. I have seen some reduction in fat in the sites I have injected, but I haven't ran it for too long yet.