I know there is some depreciation in some circumstances with Immune system as it goes to certain compounds. I've told this story 10 times here but I think it helps with your question. Now keep in mind, I believe the hgh had thegreatest impact but its not all it can be without test.
My little bro and I live thsi life we all do and we both run G yr round, not promoting that for everyone but pertinent to the story her. So he gets into a brawl at the club as us big muffuga's can occassionally do here not to long ago. As he walks out of the bar having been invited outside by a few gents he was hit in the eye with a piece of pipe and shattered his orbital..bad shattered!
So he is rushed in for immediate surgery. Post surgery the next day doc comes in and says well by looking at you I can tell you use things for your body but what interests me most was when we opened your face. there was literally no fat and the muscle was very clean and new looking. He said I'll compare it to surgeries I've done on newborns and toddlers, very clean and pure fatless face tissue and muscle. So bro revelas the stack and hgh and they talk more as doc is amazed. He made a 3 week appointment for a surgery progress check up. As he get there the doc calls in several other docs and all the nurses to see him. As they all leave the room bro asks, what the hell was that all about. Doc says, well what that was all about is you are healed in 3 weeks to the degree I expect to see in 3 months. 2 of the staff asked for his hgh source! Lol the doc spent much time with him and talked about wanting to incorporate test and gh to healing protocols with his surgeries. So not sure that answer is complete but definately pertinent to your question.