+ 3 "17β-trenbolone...contributes to neurodegeneration."
Not sure if this had been posted yet, but just wanted to share and read what you guys had to say.
http://www.ncbi.nlm.nih.gov/pubmed/25461682
EDIT: If you cant access it for whatever reason here is the what the article states
"Abstract
Both genetic and environmental factors contribute to neurodegenerative disorders. In a large number of neurodegenerative diseases (for example, Alzheimer's disease (AD)), patients do not carry the mutant genes. Other risk factors, for example the environmental factors, should be evaluated. 17β-trenbolone is a kind of environmental hormone as well as an anabolic-androgenic steroid. 17β-trenbolone is used as a growth promoter for livestock in the USA. Also, a large portion of recreational exercisers inject 17β-trenbolone in large doses and for very long time to increase muscle and strength. 17β-trenbolone is stable in the environment after being excreted. In the present study, 17β-trenbolone was administered to adult and pregnant rats and the primary hippocampal neurons. 17β-trenbolone's distribution and its effects on serum hormone levels and Aβ42 accumulation in vivo and its effects on AD related parameters in vitro were assessed. 17β-trenbolone accumulated in adult rat brain, especially in hippocampus, and in the fetus brain. It altered Aβ42 accumulation. 17β-trenbolone induced apoptosis of primary hippocampal neurons in vitro and resisted neuroprotective function of testosterone. Presenilin-1 protein expression was down-regulated while β-amyloid peptide 42 (Aβ42) production and caspase-3 activities were increased. Both androgen and estrogen receptors mediated the processes. 17β-trenbolone played critical roles in neurodegeneration. Exercisers who inject large doses of trenbolone and common people who are exposed to 17β-trenbolone by various ways are all influenced chronically and continually. Identification of such environmental risk factors will help us take early prevention measure to slow down onset of neurodegenerative disorders."
- Bookmark
- 3
- 0
Have had some minor memory issues after my heavy tren cycle, don't know if this relates, but the short term memory issues just seemed to correlate with my last cycle , just thought I would share .
Thanks for sharing
If There any pregnant rats here on eroids (and I suspect we do have a few rats--although I don't know if any of them are currently pregnant), they have a big problem on their hands....paws.
When I buy an energy drink, I always look for the one with the most warning labels.
And the author based this assertion on what?
NOT a legigtimate scientific study, and absolutley NO data to support this.
None.
100% agree.
love these studies, oh did they mention how much they were giving the rats? what does a rat weigh like 1 pound?
well if your giving the rat 1-2mg I can see your point, a 200 pound guy injecting 200-400mg/d would most likely cause some problems. But without doses we can only guess at what they mean. why even do the study? or rather do the study with a dose that is reasonable so you can post it.
The IUPAC designation for Tren is 17β-Hydroxyestra-4,9,11-trien-3-one. Is there any other kind of Tren? It's unclear to me what the emphasis on 17β is supposed to tell us.
Е jебигa сад. Сви смо ми животинjе.
Who let the Serb in? Lol
Translated:
"Fuck, now we are all animals."
To the Serb:
Једина животиња овде је твоја мајка!
Did you have to bring my mother into this and take karma ?
€:::8
Yes, I had to bring your mother in to this, and no, I didn't take any of your karma. Not sure who did that. I'll give you +2 for being a good sport though brothA.
Thanks !
LMFAO!!!!
Animal studies are often the best we can get, but it's important to remember that rats aren't humans, and thus animal studies must always be taken with a grain of salt.
I do know some people who have suffered nerve issues that may or may not be related to tren ...
Fuck! Another reason!
People eat tren when they eat factory farmed beef. Interesting.
Thanks for the link mountain. Will definitely be giving this a read during my break (meaning in between work haha)
Edit: well my former institution isn't listed there for free access, so I guess I'm fucked out of that one.
If you still cant access the link I posted the abstract.
Thank you. I appreciate it. Interesting read.
It is certainly an interesting read. Tren has never been touted for its health promoting effects so it's not a super surprise but it also doesn't really say how severely an adult would be effected. Glad I don't use tren though