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  • GreatSpear's picture
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  • Myostatin inhibitors?

  • GreatSpear   •   Tue, Sep 10th, '19 13:43   •   19 replies, 227 views

Back in 2007 I remember reading an article in a scientific journal that talked about “double muscle” cows and the research of myostatin inhibition as a cure for muscle wasting diseases. It ruminated about the possibility of people being able to go to the doctor, get a shot and have well developed muscles without working out, and for it’s potential abuse.

That article has stuck with me all these years and I still think of it from time to time. I’ve been digging around a bit and saw some info on YK-11, Follistatin, HMP, and ACE-031. Most of this information was years old and couldn’t find much information that talks about it recently.

Has research and progress about this essentially stalled out or been given up on? Does any of it actually work?

Edit:
https://en.m.wikipedia.org/wiki/Myostatin-related_muscle_hypertrophy
Wow, that 12 year old with the disorder is jacked. Apparently the Chinese are still researching gene editing it.

Found this list of current inhibitors in testing:
https://musculardystrophynews.com/myostatin-inhibition/

Comments

  • giardap's picture
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  • giardap
  • 2 weeks ago

The follistatin we buy doesnt work

The one delivered by virus does and is under research

  • EBSNW1's picture
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  • EBSNW1
  • 2 weeks ago

I don't think that there is anything out there that truly works in the way we would want it to. At least nothing that I have seen or heard about that had any good effects.

However, genetic doping is the way of the future. It is said that some of the top bodybuilders genetically lack myostatin and that it is one of the reasons for the insane muscularity that they can achieve.

With some big pharma companies cutting their research on these inhibitors it might take a while before we actually get anywhere.

  • johnmarshall12's picture
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  • johnmarshall12
  • 2 weeks ago

Good topic! It would sure be nice to find some substances that could enhance our gains along with GEAR! +

  • WelshNmad's picture
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  • WelshNmad
  • 2 weeks ago

Its certainly an interesting topic, I wouldn't be surprised if it's possible now using CRISPR on the unborn, but western scientists are too bound by the ethical and legal aspects

Whoever comes out with a breakthrough myostatin inhibitor will make a fortune regardless

  • GreatSpear's picture
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I had seen some articles talking about potential “gene doping” using crispr and viruses. Also talking about how gene doping is currently impossible to detect, and unless you had an earlier genetic sample to compare it to you would never know.

  • levelup's picture
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It’s also not reversible...there is no point to even the theoretical potential of this class of drugs until one is at their peak level and in need of just a bit more. Really should be unthinkable for anyone who doesn’t have mr. o potential

  • GreatSpear's picture
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That’s the crazy part of it, gene doping could take someone with normal genetics and give them Mr O genes. That being said it’s mostly theoretical at this point, and there’s no telling what side effects could result from it. But it’s not hard to imagine a future like GATTACA where everyone has “designer” babies with hand picked genes and traits. Or even a future where you can change your own DNA through viruses. And not just for this, but curing genetic disorders and diseases.

  • vengar's picture
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  • vengar
  • 2 weeks ago

I know the original biotech company that began research on myostatin inhibitors, Amgen, sold off all their patents and moved on. It looks like Pfizer did the same.

http://www.pmlive.com/pharma_news/pfizer_abandons_antibody_for_duchenne_1250854

Meanwhile, Pfizer isn’t the first company to abandon a myostatin inhibitor for lack of efficacy. Novartis and Morphosys gave up on their bimagrumab for muscle-wasting disease sporadic inclusion body myositis two years ago, while Shire/Acceleron and Amgen have also chalked up failures in this category.

  • GreatSpear's picture
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That does explain the lack of recent research! Thank you for that info.

  • press1's picture
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  • press1
  • 2 weeks ago

Interesting question. Here's one for ya though lol - Would you rather get big and strong without having to do any training or still do the current method of needing to train, run compounds and eat?? I'd still go with the training method as 80% of the fun is lifting the weights and the way it makes you feel for the next 24hrs after :)

  • GreatSpear's picture
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For sure, working out has been a hobby, if not a passion, of mine for years now. Nothing quite like pushing your body to its limits!

That being said, it is definitely intriguing to know that in the future you could remove the limits your body sets on muscle growth by inhibiting myostatin.

  • press1's picture
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I'm sure that at some point in the future some kind of mutating gene or chemical will be engineered to bring about muscle growth without the need to break it down first to make it grow back stronger - Unfortunately I doubt we'll be here to see it though lol Imagine the online profits to be made from selling that baby when it does!

  • gapi2911's picture
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  • gapi2911
  • 2 weeks ago

Besides muscles, internal organs would grow also...not to strat with hearth...

  • GreatSpear's picture
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Research I’ve seen shows it only targets skeletal muscle and not smooth or cardiac muscle. That being said, it targets ALL skeletal muscle and some small weird muscles grow stronger too.

  • Dudeman24's picture
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  • Dudeman24
  • 2 weeks ago

Honestly I’ve been wondering the same thing I’m not sure either curious to see what ppl have on this

  • gapi2911's picture
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I would stick on what we know already for decades...and not worry to die later in few years with a ton of muscles ;))

  • gapi2911's picture
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EVERYONE can achieve muscle size on well-known ways...symmetry is anyway genetical thing, but size can be achieved IMO

  • Dudeman24's picture
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Totally agree

  • Dudeman24's picture
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Lol true