posted Mon, 07/13/2026 - 07:49
294
E2 high issue
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Hello guys,
To introduce my issue : my libido is kinda fucked up, my boo-boo is not hard as it has to be.
I am 28 yo, and actually only on test E (500mg/weeks).
I inject it EOD.
I did my blood test and my result speak itself…
Estradiol : 121 pg/mL ; 444 pmol/L
SHBG : 6,9 nmol/L ; 0,7 ug/mL
Prolactine : 19.9 ng/ml ; 421.9 mUI/I
The rest of the test are good.
What am i supposing to do? Arimidex?
Appreciate your helps guys.
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Def need .25 arimidex that simple
I'm curious why people are stating mast will help e2. It won't aromatize estrogen, but it's not an AI either. Yes it will lower SHBG, but that's not going to lower estrogen either. I'm not saying it's wrong, but I would like to know the rationale. Perhaps he can help symptoms, but I don't believe it will do anything for E2. If someone didn't want to use Primo or EQ reducing the dose of testosterone or adding an AI would seem like a way to go for me.
I prefer Mast because I can run E2 higher without the gyno or the symptoms. I wouldn’t recommend it for someone already experiencing high E2 with symptoms. In that case I’d go with aromasin. Then I’d try to control E2 with low dose primo. That’s just me. Sticking with aromasin or arimidex is also an option.
.25e3d adex. Get that e2 down towards 50. I'd also run 400mg ed of vitamin b6 get that prolactin down towards 12. I prefer aromasin but you got what you got. If you don't run adex e3d then you will get rebound estrogen as its not suicidal like aro.
Adex lowers igf1. Aromasin raises igf1. Aro isn't as easy on picking a dose but 12.5 Ed for a week and test bloods. 6.25ed keeps me happy on a large cycle. All Ai use takes blood testing and keeping notes to map your body
I didn't know that about Aromasin raising igf.. I've read it isn't supposed to have bad effects on cholesterol like Arimidex. Have you noticed anything with that??
Cholesterol gets miffed by much of what we do :(
it WorksAromasin lowers estrogen levels by blocking the aromatase enzyme. In the body, estrogen naturally plays a role in suppressing the production of IGF-1. When estrogen is significantly depleted by AIs, this suppressive effect is removed, which generally leads to a compensatory increase in circulating IGF-1 concentrations.Clinical SignificanceMusculoskeletal Pain: The rise in IGF-1 has been linked by medical researchers to the onset or worsening of joint and muscle pain (arthralgia), which is a common side effect experienced by patients taking aromatase inhibitors.Therapeutic Effects: In the treatment of hormone-responsive breast cancer, researchers often measure IGF-1 and its binding proteins to better understand the systemic biological actions of the drugs.You can find more clinical details about how exemestane impacts the IGF axis on PubMed or read about the associated musculoskeletal impacts via NCBI.If you are taking Aromasin or a similar medication, I can help you find official prescribing guidelines, or we can look into ways to manage specific side effects like joint pain. Let me know what information you need!
^^^^ low e2 causes joint pain but we knew that...
I've been contemplating switching from arimidex to aromasin since I found this forum years ago and always change up because I know exactly how much arimidex I need to take to eliminate estrogenic side effects and stay in a good range. The next time I order anything I'll be throwing aromasin in the mix. For sure this time. Good info @Jockstrap
@NWApatches just keep in mind that aromasin is strong so use bloods to m a p it out same as with any cycle. Good luck!!
Def. Lol....
You can do two things.
1) Arimidex, I personally don't like this choice, I fall under the propaganda that it is "poison" lol. If you really need it, and sides are in place aka sensitive nips, no libido, lethargic, low energy, mood swings, etc, then use it but slowly work your way up so you don't crash ur e2. High e2 is better than crashed e2 by a million miles.
2) Your next option is throw in either Mast or Primo instead of an AI and let those compounds compete for the receptor instead. Primo specifically if you run anywhere between 3:1 - 1:1 has been shown to be really good at controlling E2. Plus you get the other benefits that come primo, and primo also is one of those DHT derivatives that are not THAT harmful, liver toxic, hair toxic, etc.
First off let me start with if you think high e2 symptoms suck then having no e2 is 10x worse. 70-80pg/nl e2 i need to grow properly. Id start .25mg arimidex once a week. Symptoms still there after a week then .25mg every 3 days. If still "negative" sides then .5mg every 3 days and so on. Everyone has a different sweet spot and everyone has their own definition of what "negative" sides are.
I couldn’t agree more. I felt a preview of being a brittle 80 year old when I crushed my E2 with EQ. It is a horrible feeling.
What’s your test results total, free and bioavailable
Everybody is different bro I really can't stand the anti ai crowd, we all aromatize differently. Even at trt doses sub 15% I'll need a little bit. You need to find what works for you but you should start slow.
“You need to find what works for you.” This is the answer. There are best practices and tried and true ways of getting to our goals but we all respond differently to these compounds.
Preach!
thanks, i guess i aromatize a lot, i will go low and see. thanks for your help
Some telltale signs for me are getting extremely emotional, angry short tempered etc, tearing up at random shit, no morning wood, make sure you get an ultra sensitive e2 test. You definitely don't want to crash it so start conservatively, wait a couple days and reassess
i have all this thing actually fml… Can’t even having good times with my GF so i hope anastrozole will do is job fast
Not to cut into yall dudes convo but Proviron or mast p will get you back fast. It dam sure should. It will crush your shbg though. Which isn't good in the long term either.
I'll give you a tip that we've ask estrogen related issues for me. There will be people after me who soak tip what i say. This is what worked for me. Clomid and Proviron. Only need 25mg of Proviron and 50mg clomid for a week, then drop to 25mg. Both for 30 days. After that take Arimidex. 1mg on days you do shots. That's going to depend on your dose too of course. So you won't need that much Arimidex if your doing less. You could even start out at. .5mg and see if that holds you.
Beware of the experts who have no pictures to show themselves and try to sound to smart with a.i. responses. As these aren't their personal experience but Google or a.i. lookups that you could do yourself that they share with you. Take advice with a grain of salt. Not everybody is the same. Time and experimenting is the only thing that will show you what exactly you need.
appreciate your answer mate, i will try that
1mg of adex you for real?? That shit would crash me like no tomorrow the few times I’ve needed to take it .25 put me lower than I wanted to be
Everybody diff buddy..
Not too be a dick but you don't look like a bodybuilder at all in your pics.
I'm not here to argue about gear advice with people who don't even look like they workout. No offense. If you only seen me in the gym and what i lift once you'd be one of the guys follow me around bothering me for advice. But on here people can be whoever they want.
I bet you are SUPER fun to hang around
I try not to be a typical hard heard douchebag from NYC. But I'm Italian and Irish so it's not easy. Lmao.
I really do pick up crazy heavy shit and put it down. But i pick it up wayyyy easier than i put it down. So how can i not be full of myself, ya know?
I’m not arguing I’m asking dude genuinely asking. Yes I lost a lot of muscle for the 2 car accidents I was in was unable to get out of bed for about 6 months it’s been a long road of recovery for me. But you do you homie
And this is exactly why i stopped posting on this site.
I get that but I think it’s wild to suggest that high as a starting point where u like to have ur e2 at? I prefer below 130 ideally 60-100 range
That wasn't the starting l starting point. What i said was taking the clomid and Proviron that may get things back to regular for him. Enclomiphene would be even better. I just have the cheapest route. The Arimidex was a after thing. And i clearly said. You may want to start lower. And possibly lower than that depending on amount he's taking
I'm telling him what worked for me. Not from an anecdotal stand point from a referance range. I said this is what works for me. Then suggested he may want to start lower. You share what worked for you right. Then you want to criticize what i said worked for me. The thing is i had this exact problem for a bit before figuring it out. So should he listen to me, you? The next guy? Or maybe he should try ask 3 with who had the closest sides first until something works. Maybe do his own tests.
Did i have a comment about what you suggested insinuating is ridiculous to use supps? Which many may think. No that's your thing if it works for you so be it
Didn’t criticize you homie legit said my experience that would crash me
I just took the.. "you for real??"" Like offensive..
Things get lost in interpretation on here. Cuz the tone something is said means allot about it's intention.
All good homie that was the reason I followed it up with that would crash me .25 in the past once a week dropped me from 150 to 65 so seeing 1mg I was shocked tbh I didn’t know people have to run it that high. Like you said everyone different but I do everything to avoid them not saying they don’t play there part but I definitely feel better with higher e2
I agree is Def a powerful as hormone as important as test. Maybe i was a bit rash in the dosing there that why i kept going saying actually maybe .5mg or maybe even lower cuz i wad thinking it's only 500mg and that compared to what i take isn't even trt .
On another note I've had convo in texts where people get offended by shit i type and vice versa and it has to be clarified like. Wait a min. Did you just take what i texted this way. Then they're like yeah. Then it's like oh shit nah man i meant it like this. Yeah my bad guess that could've been worded better... so texting made me realize how much of what we say sometimes depends on how you say something not even what you say. Pretty interesting shit.
It’s crazy how people’s bodies react so differently. I’m probably somewhere in the middle on aromatization, but I rarely have sides. I’ve had to run 1-1.5 armidex before to get my e2 in check, and it still didn’t bottom it out (thank god). I like to run e2 high though so I generally don’t have to fuck with AI, unless the nips get spicy.
Even than that case, I’d rather just pop some Nolva tell it goes away usually about a week
I was a big serm guy anti a.i. guy for awhile. And i swear it's like my body chemistry changed or the aArimidex i had was way overdosed. I think it is a bit of a combo. I would only take Nolvadex and Proviron or Winsrol mast whatever in the cycle. I tried to take Arimidex and it Def fucked me. Then i thought must be prolactin so i take caber. Then that fucked me. I'm like bro wtf. Nolvadex want cutting it. So i take clomid. That helped the nipples but still sex issues so i take Proviron boom in perfectly fine gyno gone no sexual issues. Bro believe it or not after that i have never had estrogen related issues ever since. I did start to take Arimidex 2mg week on the days i did shots. And even without it i was fine. Just within the last 2 months i stated getting sore nippke again. It's nothing though and it is gone now. I cleared it up
Yea, I got some Ralox and Nolvadex on the way right now. Gyno has been the only symptom that I’ve ever had with high e2. I consider myself pretty lucky. With daily injections I’ve mitigated a lot of the huge e2 peaks I was having.
in your opinion what is the best range for E2? (i know everyone is different about this)
To say one range for everyone is good. You need to figure out what's good for u. I like higher range probably over 100 but i don't like the acne and puffy it also makes it hard for me to bust off. Lol so ideally probably 80. I don't get bloodwork at ask really though cuz the state i live in you need doctor to sign off. So i go by symptoms side effects. At this point i have been doing gear for years. I had diff my first cycle at 19. And on and off for a bit non stop for years an years now.
And when i stared older guys didn't go by numbers they went by sides. Cuz they really didn't do bloodwork at all
When i do get routine blood work done though. Everything is fine.
First thing I would try is daily injections they made a huge difference for my e2
Secondly get yourself DIM (diindolylmethane) it helps metabolize estrogen and does wonders for water retention I take 300mg a day as well as Calcium D-glucarate may help your body eliminate metabolized estrogens, complementing DIM’s effects on estrogen metabolism.500mg twice a day
I’ve seen it lower e2 by over 20 points with just those changes if you’re still running into issues maybe add some primo to the mix
I try to avoid AI at all cost I want the estro to help me grow but if the side effects are too much to handle that’s the route you go