shredski's picture
shredski
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+ 5 PP Cruise Bloodwork

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So I’ve been running the ParaPharma Testo C 250 for 6 weeks running 24units (60mg) EOD. I would say it’s safe to say the Jano that @teamroids posted showing 269mg/ml is accurate because my levels jumped nicely.

Also I forgot to not have sex prior to labs but I wouldn’t have said no to the early morning delight either way so I’m pretty sure that was the reason for the elevated prolactin. Had mri and know there’s no pituitary adema or tumor so I’m good there.

E2 is a little elevated but having zero sides besides a little water retention but I’m going to be adding 100mg primo and see where it goes.

Gonna dial it in and switching to PhamaQo Test C 200 gonna pin that at 50mg eod and see where it goes

So I ran everything through ChatGPT had it analyze my numbers and it came back with an estimate on the total test levels being around 1700-1800 which is pretty awesome because in the past it would take 200mg a week to get me to 1200

Still debating wether to just be happy with the numbers and run my blast or dial it back to 50mg eod test and get bloods to see those number below the 1500

What do you guys think?

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Petecastiglione's picture

Para def on my top 3 brands

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Storm Ayden's picture

Good numbers and a clean panel overall your cruise is doing what you want. A few things worth addressing, including a correction on one piece of your reasoning and a note on the NPP/prolactin question you asked.
The testosterone and the ">1500" ceiling:
Your total test came back >1500 (LabCorp capped, the annoying ceiling you and Rumple were discussing), free test 40 (high). On 60mg EOD (~210mg/week) that's a strong response, and it does suggest the ParaPharma dosed accurately your levels jumped well. On the ChatGPT estimate of 1700-1800: be honest with yourself that that's a guess, not a measurement. An AI estimating your total test from your other markers isn't a reliable number it can't actually know where you are above 1500, it's pattern-matching to typical ratios. So treat "1700-1800" as a fabricated number, not data. The real answer is "above 1500, exact value unknown on this assay." Your plan to use Rythm Health (uncapped) for the next pull is the right move that's how you get an actual number instead of an AI's guess or a capped reading. Until then, "over 1500" is all you actually know.
On your dose decision (happy with it vs. dial back to under 1500):
This is a cruise/TRT-dose question and I'll keep it to what the bloodwork says rather than telling you what to run. The bloodwork-relevant point: your free test at 40 is well over range, and your SHBG is 45.5 (mid-range, actually healthy not crashed like a lot of the guys running heavier). With SHBG that reasonable, your free-to-total ratio is sane. The question of whether to dial back to get under 1500 is partly practical (so the assay can read you, which helps you dial in future doses) and partly about how high you want to cruise. From a purely bloodwork-health standpoint, getting an actual readable number is useful for managing this long-term, so dialing back enough to get a real reading (or using the uncapped lab) has value beyond just the number it lets you actually titrate. But that's your call on the cruise dose.
The prolactin you already did the most important thing, and here's the read:
Prolactin 24.9 (high, on the Roche ECLIA). You correctly identified the likely cause you had sex the morning before the draw, and that genuinely elevates prolactin acutely (prolactin spikes after orgasm and can stay up for a while), so a pre-lab "early morning delight" is a real and common reason for a transiently high reading. So this 24.9 may well be artifactually elevated by that, not a true baseline. More importantly: you already got an MRI and confirmed no pituitary adenoma or tumor, which is exactly the workup that matters for elevated prolactin that rules out the serious cause, so you're right that you're good there. That's genuinely the responsible thing to have done, and it means your prolactin elevation isn't hiding something dangerous.
So on prolactin: likely partly the pre-lab sex inflating it, serious causes ruled out by MRI, so the 24.9 isn't alarming. Recheck it next time without sex beforehand to get your true baseline if it's normal then, confirmed it was the acute spike.
Your NPP question masteron plus dopamine support is the smart combination:
You asked Aggieguy whether to drop prolactin before running NPP, and you're going to be adding something to manage E2 anyway so here's the approach that covers all of it. Consider masteron instead of primo, plus add P5P and L-tyrosine for prolactin control.
The masteron logic: NPP is a 19-nor with progestogenic activity, and on a 19-nor, elevated prolactin plus the progestogenic load is the classic setup for progesterone/prolactin-related gyno. Masteron has genuine anti-progestogenic and anti-estrogenic activity at the receptor level so it works against the NPP's progestogenic gyno pathway at the source, and it brings your E2 down. Primo is fine for the E2 side (mild, non-aromatizing), but primo doesn't have the anti-progestogenic action so on a cycle where you're adding NPP and worried about prolactin/progesterone, mast is the more synergistic choice because it blunts the exact 19-nor gyno mechanism you're trying to get ahead of, while also handling the estrogen. One compound covering both your current E2 and your upcoming NPP concern.
Then layer in the prolactin support directly: P5P (the active form of B6) and L-tyrosine. The mechanism here is dopaminergic dopamine is the body's natural brake on prolactin (it's what suppresses prolactin release), so supporting dopamine keeps prolactin down. L-tyrosine is a dopamine precursor, so it provides the raw material to upregulate dopamine production, which in turn suppresses prolactin. P5P lowers prolactin as well and is a reasonable first-line at a higher dose (200mg+). So P5P plus L-tyrosine work the dopamine/prolactin axis to keep prolactin controlled, complementing the masteron's anti-progestogenic action. Together that's a strong, gentle, upstream approach: mast blunts the progestogenic pathway at the receptor, and the P5P/L-tyrosine support dopamine to suppress prolactin covering the NPP gyno risk from two angles without needing to reach for stronger drugs.
On the caber question Aggieguy raised: with the masteron providing anti-progestogenic coverage AND the P5P/L-tyrosine supporting dopamine to keep prolactin down, you may well not need caber at all on the NPP those gentler tools handle it upstream. Keep low-dose caber in reserve only for if prolactin genuinely climbs on the NPP despite the mast and the dopamine support. And don't reach for caber to knock down the current 24.9 reading, since that's likely the pre-lab sex artifact get a clean baseline (no sex before the draw) first to see your true resting prolactin before adding anything to chase it. The combination of mast + P5P + L-tyrosine is the upstream play; caber is the last-resort backup if that combination isn't enough once the NPP is running.
One tradeoff to flag on mast: it's a DHT derivative, so it can worsen hair loss if you're genetically susceptible, and it adds to the androgenic load whereas primo is gentler on hair. So if hair retention is a priority, that's the consideration that might tip you toward primo (in which case you'd lean more on the P5P/L-tyrosine and caber-in-reserve for the prolactin side, since primo wouldn't be covering the progesterone angle). But purely for managing E2 plus the NPP prolactin/progesterone risk together, mast plus the dopamine support is the more complete combination.
The estrogen:
E2 68.8 (high, Roche ECLIA), with only minor water retention as a side. The masteron addition handles this alongside the progesterone angle mast's anti-estrogenic effect nudges E2 down without an AI, which at a TRT-ish cruise is the gentler approach. Just note mast's E2 effect is modest, so don't expect it to dramatically drop 68.8 it'll help. Since the water retention is your only E2 symptom, it's a symptom-driven adjustment, which is the right way to do it. Don't over-correct.
The genuinely reassuring stuff:
Your thyroid is fine (free T4 1.47, TSH 0.795 both in range). Your iron panel is good (iron 138, saturation 47%, TIBC 296 all normal, saturation at the upper-comfortable end but fine). SHBG 45.5 is healthy and mid-range, which is nice to see it means your free hormone fractions are sane. Cortisol AM 7.9 and ACTH 13.6 are both normal. And the expected-on-cycle findings: LH <0.3 and FSH <0.3 (both suppressed, exactly what you'd expect on exogenous test natural production shut down, normal for being on cycle). So your thyroid, adrenal, iron, and SHBG picture are all clean.
One note on the LH/FSH being suppressed: that's expected and normal on TRT/cruise. The only time it matters is you mentioned you were off TRT for years to have kids and came back because your test was in the dirt (2 pg/ml) with zero libido so just be aware running this suppresses fertility again (LH/FSH at <0.3 means minimal testicular signaling), which matters only if more kids are a future consideration. Not a health flag, just a fertility note given your history.
Bottom line on the bloodwork:
Clean panel, good cruise. Prolactin (24.9) is likely partly the pre-lab sex inflating it, and you've already ruled out the serious cause with the MRI, so it's not alarming recheck without sex for a true baseline before the NPP. For the E2 and NPP together: consider masteron over primo (handles E2 and the NPP's progesterone pathway at the source), plus P5P and L-tyrosine to support dopamine and keep prolactin down that combination covers the gyno risk upstream from two angles, and you may not need caber at all (keep it in reserve only). Mast's tradeoff is it's harder on hair. Ditch the ChatGPT 1700-1800 estimate (it's a guess) and use the uncapped lab for a real total test number. Thyroid, iron, SHBG, adrenal markers all clean. Main actionable items: uncapped lab for a real number, clean prolactin baseline, and masteron + P5P + L-tyrosine as the combined approach for E2 and NPP prolactin/progesterone protection.

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shredski's picture

Thank you homie much appreciated you really hit home on a lot of things I needed a little clarity on. I definitely like the approach you mentioned with running mast over primo I can easily use that for my cruise afterwards. Dht is zero concern I’ve been bald for years and accepted it and the fertility issues are none as I got snipped as why I went back on gear. So thank you again for your knowledge. So in your opinion should I lower the dose add primo for the next 6 weeks and pull bloods with rythym so I have a dialed in cruise next time? Or am I over analyzing this and be happy with the results and stay the course on the next cruise and just go full send sis npp mast?

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Storm Ayden's picture

Glad it helped, homie. And good news you just removed the only two complications that would've made this a harder call. Bald and at peace with it means mast's hair tradeoff is irrelevant to you, and the snip means fertility's off the table entirely, so the suppressed LH/FSH is a complete non-issue. That actually simplifies your decision a lot, because the things that usually make people hesitate on mast or worry about cruise suppression just don't apply to you. Mast over primo for the cruise is a clean choice for you now.
On your actual question dial it back and dial it in, or be happy and full send here's my honest take, and I lean toward the first option, but not because you're over-analyzing. You're not. Here's the reasoning:
The case for lowering, adding mast (I'd do mast over primo here too, same logic as before it covers E2 and sets you up for the NPP later), and pulling bloods with Rythm: you'd actually know your numbers. Right now you're flying with a capped ">1500" and an AI's guess of 1700-1800 that isn't real data. If you dial back to something like 50mg EOD, add the mast, and pull uncapped bloods in 6 weeks, you come out the other side with a dialed-in, verified cruise you'd know your real total test, your E2 with the mast on board, your prolactin at a clean baseline (no pre-lab sex this time), and you'd have a cruise dose you actually understand. That's worth a lot, because then when you DO blast NPP/mast, you're building on a known foundation instead of guessing. You'd be going into the blast knowing exactly where your cruise sits, which makes the whole thing more controllable.
The case against full-sending the NPP/mast blast right now: you'd be stacking onto a cruise you haven't actually measured (capped test, prolactin reading confounded by the pre-lab sex, E2 not yet managed). Adding NPP a 19-nor with the progesterone/prolactin gyno risk on top of an unmeasured baseline means if something moves, you won't cleanly know what's driving it. Whereas if you spend the next 6 weeks dialing in the cruise first (lower dose, mast, clean uncapped bloods), then your blast is launched from a known, controlled starting point with the mast already proven to be handling your E2 and the progesterone side.
So my honest opinion: dial it back, add the mast, pull the uncapped Rythm bloods in 6 weeks, get your verified dialed-in cruise then blast from there. Not because you're over-analyzing, but because the small bit of patience now (6 weeks to establish a known cruise) pays off in a blast that's built on real numbers instead of guesses. You've already got the instinct to want your numbers under 1500 so you can read them that instinct is right, follow it. Getting a clean, measured cruise dialed in is the foundation that makes every cycle after it more controllable, and you're one 6 week window and one uncapped blood pull away from having it.
The "be happy and full send" option isn't wrong your numbers are good and you're not in any danger it's just that you'd be blasting on an unmeasured base, and you specifically said you'd like to know your numbers to make dialing in easier. So the move that serves what you actually want is: 6 weeks at the lower dose with mast, clean uncapped bloods, dialed-in cruise locked in, then send the NPP/mast blast from a foundation you fully understand. A little patience now buys you a much more controlled blast later and the prolactin support (P5P + L-tyrosine) plus the mast means when you do add the NPP, you've already got the gyno pathway covered from multiple angles.
Short version: you're not over-analyzing, your instinct to get readable numbers is correct, so dial back + mast + Rythm bloods in 6 weeks = dialed-in cruise, then blast from there. Build the blast on known numbers, not a capped reading and an AI guess.

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bamboo2112's picture

I am starting to think we need to give you your own advice column. Not only do you explain the good and the bad but how to correct it and why. Thank you for putting in the work!

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Storm Ayden's picture

It's always a pleasure to help out this community.

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shredski's picture

Straight slaying facts my guy thank you I’m gonna start the mast Friday. Would you think 1:1 ratio would be ideal with trying to utilize the mast for e2 regulation

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-Infidel-'s picture

I know you have been going back and forth on what compounds you were planning on using… if you were to blast, what’s your cycle gonna look like?

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shredski's picture

I plan on doing sust 350 npp 250 primo 175

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-Infidel-'s picture

I’d say run it

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shredski's picture

@StormAyden would like your input you’ve been rocking some solid replies to bloodwork questions lately

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Aggieguy's picture

You can knock that prolactin down with some Caber

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shredski's picture

So I plan to run some npp on the coming weeks you think it’s a good idea to drop that prolactin prior ?

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Aggieguy's picture

Yes 19 Nor raise prolactin

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Rumple's picture

Pardon my ignorance but in the testosterone reading, is all the data you get more than 1,500?

shredski's picture

Yea unfortunately this lab reference limit is 1500 which sucks cause I’d like to know how much over the 1500 I am would make dialing in my dose a little easier so now I drop and see if I get it under the 1500 in 4 weeks

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Rumple's picture

What a bummer. I've never seen that which is why I ask. I do my tests at Quest through Good Labs, is this at Lab Corp?

shredski's picture

Yep they stink but I live in shit state and my insurance only covers lapcorp

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Rumple's picture

Well shit, at least your insurance is covering the blood work. My insurance is shit and my PC doctor will only order if you are on your death bed.

shredski's picture

Healthcare in general is shit I know more about hormones than prescribing doctors smh

Also I had ChatGPT analyze the results and based off all the other readings it came back with an estimated range of 1700-1800 . Also reached out to rythym health they said they have reading higher than 1500 so I’m gonna do that for my next pull

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Tanman's picture

Is there a Quest Diagnostics near you? I get my orders through goodlabs for super cheap and they are uncapped.

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shredski's picture

I live in a shit state where I have to have a doctor order labs. Goodlabs I can use bioreference but that shit is mad expensive from them.

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Tanman's picture

Good looking numbers, but I'm going need you to sharpen that knife Sir. Hurts my soul to see an edge like that lmao. I also have a problem, knives were my first addiction and I own several thousand $$ worth of kitchen and pocket knives as well as couple grand in sharpening stones and equipment, so I'm extra judgy about other people's shit lol.

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shredski's picture

Lmao in all fairness this is my work knife which is used for things knifes are not supposed to be used for like stripping wires and popping curb boxes lol also if I need to shank someone blunt tip way more damage lol

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liverpool_96's picture

These are good numbers indeed and pardon me but I'm glad to see someone else have high E2 on a moderate dose of test. Do you usually cruise on upwards of 200mg per week? I think that is quite high but I guess it depends on each individual. When does the exciting stuff happen and what do you have planned for the next blast?

shredski's picture

So I was off trt for the last few years so that incpuld have my kids. I just recently started up again because my first test was in the dirt 2 pg/ml and had zero libido. Prior I ran 200 and my total test hovered at the 1200-1300 levels so that’s where I started to dial it in. I’m gonna make the changes and see where I’m at in 4 weeks. Hoping to see my total test at-least in the range to be read and then I’ll use that dosage going forward. Once I get those numbers I plan on a blast

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