A big part of this supplement is to make sure you don't eat at least an hour before and after taking it otherwise it's not gonna work good because it works thru insulin spikes. But if you take it without some kind of insulin control type pills it will raise your a1c alot. The best is to have pills with berberine as main ingredient plus things like chromium, cinnamon extract , alpha lipoic acid and other things. There's a few blends out there I like. Because the same goes with reg hgh if you have way to high insulin resistance, your not gonna get the positive effects from the compound your taking. Same goes with the ghrp 2, cjc ipa and those peptides but nobody wanna stick themselves multiple times a day with multiple peptides that's why I always tell people it's either hgh or MK but some will still do the peptide route.