Read about this a few months back on the news. Definitely have my fingers crossed for it as my hair has been thinning for the last few years. You KNOW it will be outrageously priced if it passes all it's trials and makes it to market. Just like anything else anymore...
Never heard of it - PP405 is a novel, non-invasive, topical small molecule designed to reactivate dormant hair follicle stem cells and restart hair growth.
It is a potent topical mitochondrial pyruvate carrier (MPC) inhibitor that acts on the cellular metabolic pathway to upregulate lactate dehydrogenase (LDH), which stem cells are particularly sensitive to, resulting in their activation and hair growth.
Data presented at AAD showed in human facelift skin, single topical applications of 0.006% and 0.06% PP405 led to an increase in LDH activity in hair follicle stem cells within 24 hours.
The findings demonstrated proof of mechanism in human explanted skin consistent with the results in animal models.
The data informed Pelage's Phase 1 clinical trial that concluded in January 2024, which demonstrated that PP405 was safe and well-tolerated, with the target pharmacokinetic profile achieved.
I’ve been seeing a lot of content on social media about this especially TikTok from balding men and thin haired women. What’s everyone’s thoughts or experiences? I’m hoping this will work for my wife as all of my babies she has had has been hard on her body and it’s affected her hair growth.
Read about this a few months back on the news. Definitely have my fingers crossed for it as my hair has been thinning for the last few years. You KNOW it will be outrageously priced if it passes all it's trials and makes it to market. Just like anything else anymore...
Never heard of it - PP405 is a novel, non-invasive, topical small molecule designed to reactivate dormant hair follicle stem cells and restart hair growth.
It is a potent topical mitochondrial pyruvate carrier (MPC) inhibitor that acts on the cellular metabolic pathway to upregulate lactate dehydrogenase (LDH), which stem cells are particularly sensitive to, resulting in their activation and hair growth.
Data presented at AAD showed in human facelift skin, single topical applications of 0.006% and 0.06% PP405 led to an increase in LDH activity in hair follicle stem cells within 24 hours.
The findings demonstrated proof of mechanism in human explanted skin consistent with the results in animal models.
The data informed Pelage's Phase 1 clinical trial that concluded in January 2024, which demonstrated that PP405 was safe and well-tolerated, with the target pharmacokinetic profile achieved.
Sounds like a scam to me
I’ve been seeing a lot of content on social media about this especially TikTok from balding men and thin haired women. What’s everyone’s thoughts or experiences? I’m hoping this will work for my wife as all of my babies she has had has been hard on her body and it’s affected her hair growth.