@Musclemem and I were discussing prolactin related sides and how to stop hot flashes dead in their tracks.

This is not original work, but more of a copy and paste from an old topic board,,

Vitamin B6 is a surprisingly effective prolactin inhibitor that is extremely cheap and safe: One human study showed a single 300mg dosage of B6 exerts ‘a hypothalamic dopaminergic effect’ which causes a ‘significant decrease of plasma prolactin’(1);

Another found that 300mg of B6 taken twice a day by 10 normal women lowered prolactin levels and slightly but significantly raised growth hormone levels. The authors concluded: ‘The effect of vitamin B6 is likely to be mediated by dopaminergic receptors at hypothalamic level’(2);

Another study found B6 to significantly reduce ‘opioids-induced hyperprolactinemia’(3)

This study on men found that ‘Pyridoxine (B6) suppresses the rise in prolactin and increases the rise in growth hormone induced by exercise’(4);

And a study on male rats found that, ‘Pyridoxine hydrochloride significantly suppressed the chlorpromazine-induced prolactin rise (p less than 0.01). However, the suppression was significantly less than that produced by bromocriptine (p less than 0.01)’(5).

pyridoxal 5’-phosphate.. Pyridoxal-5’-phosphate (PLP, P-5-P) is an active form of vitamin B6. This all-around vitamin enables the metabolism of amino acids, carbs, and lipids in your body. It’s involved in [1, 2]:

Supporting the immune system
Controlling blood glucose
Creating hemoglobin
Enhancing antioxidant defense
Along with vitamin B12 and folate, vitamin B6 also helps break down homocysteine and thus protects your heart, brain, and reproductive health [3, 4, 5].

Vitamin B6 is a crucial nutrient for cognition and mental health. Low vitamin B6 status can lower your brain’s production of serotonin and GABA – two neurotransmitters that control mood, pain perception, and anxiety [6, 7].

A variety of foods, such as meat, fish, nuts, grains, and vegetables contain vitamin B6. You can get enough of it from food, but supplements will provide much higher doses when you need them [8].

Your body converts vitamin B6 (pyridoxine) from food and supplements into active pyridoxal phosphate in the liver. Supplements with active P-5-P are promoted to be more efficient as they don’t require conversion, but the available research is limited.

Proponents:
Doesn’t require metabolic conversion
May be more efficient than pyridoxine
May be better for some types of infantile seizures
May be better for sideroblastic anemia

Skeptics:
Not well studied in humans
Causes digestive issues in some patients
May suppress prolactin and growth hormone
May not be safe for pregnant women