posted Thu, 03/11/2021 - 06:36
4800
+ 1 Hgh and terrible hunger pains!
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So I’m new to hgh and I’ve only been on 2IU a day for a week and the increase in appetite is insane. I know it increases ghrelin but Damn I’m starving 24/7 and I’m not trying to bulk right now lol.
Is it going to calm down? I’m also going to work my way up to 3IU so I assume that’s only going to make it worse?
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Just an update. Increased appetite has subsided after another week. Great information as well everyone. This is why Eroids is the shit!
An appetite increase sounds amazing to me.
When you inject proper HGH it causes the release of IGF-1 which makes you hungry especially for carbs. I'm not sure why people think it wouldn't cause this? - it makes me feel the same when I run it. Same as tren when you inject it especially ace, causes an increase in IGF-1 which crashes blood sugar and in turns makes you starving.
Yes, from my understanding and knowing people who have experience running hgh it increases hunger. Maybe not in some. I think we all react differently to compounds. We’ll see how it goes and how I feel overall over the next month and then do bloods.
press1, The released IGF-1 will bound to IGBP's and ALS, bound to these proteins it won't have much effect on Insulin receptors (IGF-1 serum concentration is 100-fold greater than insulin).
I'd check BG and insulin levels. There's also a chance he's running some other stuff, not HGH.
Just my 2c
RS
RS.
Just want to understand your statement well.
Are you saying that Igf1 won't make you crave carbs? Because I have gone into a certain level of hypoglycemic state while using exogenous Igf1. Shakes, sweating, disoriented the usual hypo symptoms. It is not hunger what I have experienced.
Can you please elaborate some on your statement so we all can understand this better. Will appreciate it.
PS: I'm dying to try the one you have, been studying all about it.
There's Recombinant Human IGF-1 and There's IGF-1 that your liver releases.
The Liver released IGF-1 will bind to IGFBP's (IGF-binding proteins) and ALS, this will increase your blood circulating levels of IGF-1, BUT, this IGF-1 simply won't be attaching to Insulin/IGF-1 receptors while it's bound to IGFBP's. "IGFBP3 is the most efficient inhibitor of IGF activities" https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular...
And there's free/unbound IGF-1 which will attach to the receptors.
I believe, kids, with open growth plates are the main beneficiaries of high or normal circulating levels of IGF-1, because their growth plates are constantly in need of IGF-1, which will make it to unbound from the IGFBP's and ALS and attach the target receptors.
IF 100% of blood circulating IGF-1 was free/bioactive it would make us go hypo or even kill us, as IGF-1 binds to the insulin receptor and as I mentioned "IGF-1 serum concentration is 100-fold greater than insulin"
With Recombinant Human IGF-1 you get free/unbound IGF-1, which will attach to the same binding proteins, just like the liver released IGF-1, but a bigger % of it will reach the receptors, that's why there're studies that suggest that localized IGF-1 infusions stimulate protein synthesis
https://pubmed.ncbi.nlm.nih.gov/9572822/
Long story short :
HGH/Liver/IGF-1 : most of the IGF-1 is bound to IGFBP's, ALS, some % of is unbound (aka bioactive)
RH IGF-1 direct infusions : Free unbound IGF-1, this one was shown to acutely reduce hepatic glucose production and stimulate peripheral glucose uptake.
That's why you go hypo when you use RH IGF-1 and not HGH.
Why some people may experience hunger pains on HGH, it could be insulin spikes (high/low BG)
IDK if I answered your question, LMK.
RS
Yes! You did answer my question.
Basically there's different ways of action between the one secreted by the liver (endogenous) and the recombinant (exogenous). The one secreted by the liver, will tend to bind to different proteins. The recombinant, will also bind to the same proteins but being in an free unbound state will also bind to the insulin receptors having the capacity to make you hypo. Very clear, got it.
I appreciate you taking the time to explain it in such a thorough manner.
Very helpful information. +1
Quick note, I believe, 5-10% of the IGF-1 secreted by your liver is free (unbound) and it binds to the IGF-1 and insulin receptors. But, with RH IGF-1 we get mostly free IGF-1. In order to bind to the any receptor, the IGF-1 (protein bound) circulating in your blood needs to "disconnect" from the proteins, it may never do that, by the way.
You can increase circulating blood levels of IGF-1 with RH IGF-1 too, but you need to dose it higher (a few mg's/day) It will bind to the proteins and will stay in your blood longer. One of the reasons we have Iplex (IGFBP3 + IGF-1 complex) is because some kids have low levels of binding proteins.
I posted this on my SI some time ago :
"IMMULITE® 2000", Siemens is a popular lab equipment used for blood samples analysis.
"Measurement of IGF-I in serum is complicated by the presence of acid-labile components and binding proteins. Acid treatment is necessary to release IGF-I to ensure accurate quantitation." - copied from the manual to the machine.
So those total IGF-1 #'s isn't the level of your free IGF-1, but the total IGF-1 levels of blood circulating IGF-1 bound to six binding proteins + free IGF-1. The lab is treating blood samples with a reagent that "disconnects" IGF-1 from it's binding proteins.
I would imagine that this happens because in order of priorities the Igf1 secreted by the liver needs to comply with the biological needs of the body and being less in terms of the quantity secreted, very little will actually reach the insulin receptors.
But the recombinant Igf1 being injected in supraphysiological amounts more of it will be able to reach the insulin receptors once is done supplying the basic biological disposition, therefore having a more anabolic output.
Sort of like Testosterone. The Test secreted by the testicles will be mostly arrested by the sex hormone binding globulin and very little will reach the androgen receptors. But when injected in supraphysiological amounts a lot of it will be left in an unbound state and will reach the androgen receptors.
Please correct me if I'm wrong.
IGF-1 will target it's own IGF-1 receptor and can also bind to the insulin receptor but with lower affinity and vice-versa. (I said this because you keep mentioning insulin receptor)
That's a good comparison.
I see. How interesting. I didn't know Igf1 had it's own receptor. I always thought it only mediated through the insulin receptor.
I learned something new today. Awesome!
Won't take any more of your valuable time.
Thank you for sharing your knowledge.
AnonHad to throw some plusses around. Great read. I learned some things. Thank you.
Give them a vote if you find it helpful.PermalinkI have seen a few people say they have gone borderline Hypo whilst using Insubolic - which would stand to reason as its basically a slightly safer version of Taboo is my understanding of it and the way it acts, hence the name of it.
Yes, that's my understanding of it too.
But I'm not sure I'm following his statement.
Maybe I'm understanding it wrong.
I didn't either bud.
Interesting. Yes it is possible it’s not hgh but trust the source and the other members who are using it as well and have done bloods and posted them. It may be possible that it’s a form of mk677 which for sure causes appetite increases and does increase igf.
A lot of people react differently to different compounds. My appetite stays the same on HGH (I only use pharma grade). Some people's appetite goes through the roof on trenbolone, but my appetite crashes! Are you absolutely sure you're injecting HGH?
Appetite increase/decrease are not any of the listed side effects for HGH from any of the pharma manufacturers, at least that I could find. Could it be a different substance? Maybe you're KILLING it in the gym and your metabolism is way up and/or your body is demanding more calories.
Molinin302I'm going to throw some plusses around on this one. I have a great interest in GH, but a lot to learn. Already have what I want to do planned out. It's very long, very therapeutically dosed. And I'm seeing questions in response to questions that show people are knowing what they're talking about. Keep this one going fellas, it's great so far.
Awesome! And yes knowledge is key and there is a lot of knowledge on Eroids. I’m learning all the time and do my best to share what I’ve learned as well.
Is it a sudden intense increase in hunger like 5-10 minutes after the shot? Or are you just more hungry throughout the day?
Thanks for the response. It’s an all the time thing. It started about 5 days after being on it so for the last 2 days my appetite has just been ravenous!
AnonGood question. I will +2 that.
That's a good question because if it's GHRP-6 the hunger comes on shortly after the inject but doesn't last all day. GHRP-2 can also stimulate hunger in some. Some people get other sides from GHRP's right after inject such as flushing.
Edit: Not suggesting anything is fake or something here. Just engaging in the conversation.
AnonI quick searched and did not see a GHRP-2. Maybe a little background.
AnonGHRP-6 is a first generation GHRP. I call it sloppy because of the sides it can come with: elevated prolactin and cortisol levels.
GHRP-2 is a second generation GHRP, meaning it was developed after GHRP-6.
The most noticeable difference is GHRP-6 causes a strong hunger spike shortly after injection.
GHRP-2 may cause some hunger spike but no where near as high as GHRP-6.
GHRP-2 is said to cause a slightly larger release of GH than GHRP-6 yet have a shorter half life and less risk of elevating prolactin and cortisol levels than GHRP-6.
Both GHRP-6 and GHRP-2 can raise prolactin and cortisol levels. So you shouldn't abuse them, moderate dosages of 100mcg 2x to 3x a day is where I draw the line personal for myself. And they must be cycled, 10 to 12 weeks tops. Time on equals time off. No PCT needed but time off is a must because desensitization to the effects of these peptides happens and they can come with side effects, elevated prolactin and cortisol.
If you want a cleaner GHRP with less to no sides then Ipamorelin (a third generation GHRP) is the best choice in the GHRP family. It still has to be cycled, 12 weeks tops before desensitization happens.
To maximize elevations in GH with any GHRP it is best to stack them with a GHRH such as CJC-1295 w/o DAC. Personally I run 100mcg of GHRP with 100mcg of GHRH together 2x to 3x a day. It is speculated in some circles that running GHRH for longer than 5 weeks can cause permanent damage to the pituitary gland. ngl, I have run it a full 12 weeks with a GHRP, but that doesn't mean it's safe and you should do it. Currently I like to run a GHRP solo 100mcg 2x to 3x a day for 3 weeks then add the GHRH (CJC-1295 w/o DAC) at 100mcg per injection with the GHRP for 4 more weeks then get off the shit. No PCT needed, just stop cold turkey.
Some of this is bro science I'm spitting, but that's research peptides for yah. Just play it safe and do your research if you run research peptides. If anything I have said is incorrect or I have left out some important info I take no issue with being corrected or intellectually out-gunned on this topic, so jump in.
AnonTY
Yeah bud, it’s bad all day. Only been on it for a week and I was fine until like 2 days ago. Stomach grumbling all damn day last 2 days.
Exactly. Like 3 or so years ago I believe I got ghrp6 that was being passed as GH. I have quite a bit of experience with ghrp6 (I love it) so I knew immediately it was ghrp6 rather than GH.
Not saying that’s the case here but if you’re getting very intense increases in hunger shortly after your shot. It’s possible you received ghrp6.
GrowthForGrowthI don’t want to say your gh is fake but maybe you got some ghrp instead of hgh.
That would suck! I didn’t even consider that. I was just thinking the exact opposite, this shit must be really good if I’m this hungry. It’s got good reviews and bloods posted so I think I’m good. Gonna pull bloods in a month or so anyway and see