+ 5 Double-Blind, Randomized Study on Oxymetholone and Its Positive Effects on Hemodialysis Patients
The dosage was 50 mg b.i.d. (twice daily), with the experiment lasting a total of 24 weeks. Liver enzymes were raised, as to be expected, and one patient had to withdraw due to symptoms of jaundice; however, that patient's enzyme values returned to normal one month after discontinuation of oxymetholone. Also, as to be expected, there was a decrease of all patients' HDL over the course of the 24 weeks of treatment. Oxymetholone was also shown to increase protein concentrations of IGF-I and IGF-II. All patients, excluding the one who withdrew because of a genetic predisposition, increased their lean body mass. As a result, oxymetholone use potentially saved the lives of the participants in this study, as maintaining lean muscle mass is vital to the survival of patients on kidney dialysis.
Yet another study that proves AAS use, especially if it is being monitored under a doctor's supervision, carries virtually no-- or otherwise manageable-- health risks. I would not advise anyone consume 100 mg of oxymetholone daily for a total of 24 weeks. The patients involved in this study were being treated for kidney dialysis, and all of them were being monitored by a team of doctors and nurses, during the course of their treatment. At the same time, I thought some members of the Eroids community would find this study of some interest, as research of AAS and their effects on people in controlled scientific studies is quite limited.
- Bookmark
- 5
- 0
Kidneys affect protein absorption heavily. There could be perhap a difference in lean tissue growth if healthy patients participated in the trail.
RustyhookerI wish i could find the old reports posted by phd in the magazines on liver values. Slight elevation for short periods of time aided in anabolism thru blah blah. Which is why i wish i could find them.
For me directly my concern is bp. It can be controlled thru food and hydration measures. But as we post, bp should be a daily check. Regardless.
"but it also induced liver injury." "Oxymetholone, in low doses, seems to have an important anabolic effect in MHD patients, although the potential risk for abnormal liver function is a source of concern."
Even low doses cause abnormal liver function - reason enough not to use it..
Liver values returned to baseline afterwards, which is typical of most orals. I am not saying there is no risk associated with taking oxymetholone, nor would I suggest anyone dose 100 mg's for 24 weeks (like the participants in this study), but evidently the associated risks were not large enough to cause concern to the medical staff. Furthermore, I wonder what type of hepatotoxic profile oxymetholone has when compared to other oral AAS -- unfortunately, such studies don't exist.
Fair enough - here is an interesting read - https://toxnet.nlm.nih.gov/cgi-bin/sis/search/a?dbs+hsdb:@term+@DOCNO+3374
That's one thing about oxymetholone that is troublesome -- its carcinogenicity.
Great contribution mate. I’ve seen a similar study on aids patients. However I’ll stick to running abombs for no longer than 14 days at a time / pulsing as I get 0 sides and 100% gains
Pulsing is the only way to go with the more toxic orals.
Many people would agree with this advice, including me.
Those docs should have been pulsing the drol. Much more effective that way. lol
I didn't read the study but any mention on the HPTA?
There was a decrease in total testosterone levels in the oxymetholone group.
I think that is a key point that is kind of missed in the safety of running a cycle like this which may have been overlooked. The liver is a fairly resiliant organ but the HPTA is not so forgiving.
Nice! But what If you are on TRT already?
HPTA not an issue then.
What a relief to TRT users. Ha!
I believe that's why they couldn't stand in time most of the aas created for waisting diseases correct me if iam wrong but they had to much sides!!
True. Sadly, many doctors neglect to take things such as HPTA recovery into consideration in these types of studies.
in a nutshell they dont give a fuck about fuck lol !
No kidding! 95% reduction in total testosterone from baseline. I imagine all that precious lean body mass was lost by the oxymetholone group, if not a decline into a worse state they were in prior to its consumption.
and on the 27th week they all look like shit and couldn't get a hard on !! damn
nop nothing about it !
There was, actually. Scroll down to the Hormonal Profiles section and you will see it.
yes table 5 iam blind !!
Actually, Adrol has been given to children with muscle wasting issues, at 150mg a day for over a year with no organ damage and so significant change to organ enzyme values. It is as safe as it gets for an oral steroid..
It has a use for muscle wasting but doesnt build muscle to any useful extent. Gives you a pump and some strength, great, but it doesn't 'bulk' you up.
Hi bro hope your well?
If you get time could you send me the link for that study please?
Cheers man
'Sup buddy!
Ill see if I can dig it up man, I had a load downloaded so Im pretty sure I have it saved
leave it with me!
Thanks mate,
Would be much appreciated......can read these studies for hours mate love em
I’ve read a couple studies showing the same thing. As a scrip it’s usually given in between 150-200mg a day for months at a time.
In the bodybuilding community we look at Anadrol like its eating our liver everyday we take it. In the medical field they do not think it’s anywhere near as dangerous.
Just reporting what I’ve read, not insinuating it’s ok to take large dosages for lengths of time.
Yeh I get exactly where your coming from.
I'm going to be doing alot of reading tonight bro thanks ;)
truth I ve seen this article with the kids part.but it dont build muscle? and some strength? I
Big difference between sparing/maintaining muscle mass and building actual tissue.
indeed sir ,kinda sucks though a bombs is one of my favorites !!
I am not saying it won't produce lean tissue in a trained athlete because it can and I have done it with adrol. But it has to be ran right and coupled with the proper training and diet. Over the course of pulsing it over a 2 month period I can say I have put on around 3 or so pounds of lean tissue which is pretty significant I believe. Expecting much more than that may be unrealistic. Yeah I put on 12+ pounds while taking it but what matters is what is kept after your course of it is done. Superior glycogen retention is where all the weight comes from and that disappears when you stop.
Yeah the clinical trial is there to see, with the kids. Phenomenal stuff.
Strength increases, well absolutely. Adrol is great for that.
As for muscle building... well I know that they absolutely have seen recovery in muscle wasting, right, in different illnesses, predominantly measured via *na expression and bodyweight. So, technically it promotes the right environment for muscle building via protein expression etc... but so does drinking milk... Now what we are mostly talking about here are 6 month, ~2.5kg recoveries. But not muscle building by AAS users starting from either an experienced baseline, or normal joe soaps for control subjects.
Anecdotally speaking only, I can tell you in very high doses over medium time, it has done nothing for me other than strength and pump. That's with a trt dose of testo only, so virtually a test of anadrol only. Doses I am talking are greater than the kids trials.
Unlike with deca etc, I've never read studies of anadrol for AAS users. Must look into it, see if any exist.
interesting ,what about deca you mention ? it increases muscle mass with out training ? surprised tbh cause never ran it for a long time usually palse it or 4 weeks straight ,and never solo so couldn't tell whats from what !!
Absolutely, to an extent. Same with testosterone. But, there are several highly significant nandrolone trials of trained AAS users versus trained natural non-AAS people. The muscle growth is there and significant and measured, and therefore relevant specifically to us lot.
There were some great dianabol studies where they proved the weight gain from dianabol was not muscle at all, despite there being lean body mass increases... with guesses it might be collagen related among other things.
Coupled with exogenous testosterone, would substances like anadrol, much less dianabol, produce gains in real muscle mass? Another thing these studies lack, at least the ones I have seen, is no empirical research into the synergy of 2 or more AAS drugs being used simultaneously. What doesn't make sense is how nadrolone shuts down natural testosterone and is still able to produce muscle growth in untrained individuals. I wish we better understood these types of things.
honestly, its a lot more simple C.
nand is synthetic testosterone (a test derivative), designed to have a higher binding affinity to the androgen receptor and therefore activate it quicker.
Ive run zero test with a chunk of nand - the only place it fails is in how little it converts to estrogen
anadrol is also a synthetic testosterone derivative, but it competes in a weaker way for the andro receptor, so it loses everytime. thats why i say its a particularly rubbish muscle builder.
I think u got it mixed up, deca binds poorly to the androgen receptor, but has a much better binding affinity to muscle tissue. Dan Duchane wrote it in his book, but he has been wrong before. It is also why women can use NPP but stay far away from test.
You don’t need testosterone to grow. Just AR stimulus and estrogen, and nandrolone will provide both of those in spades. Sure testosterone is a better estrogen source but in a pinch nandrolone will do.
Of course! I should have worded it a little differently than I did. Giardap pointed out that oxymetholone produces very little lean tissue growth in untrained individuals relative to something like nandrolone. I wonder why that is, because it still awakens estrogen receptors (through some unknown mechanism). I am curious about the mechanism behind it.
I believe a large part has to do with binding affinity. That and the long ester nandrolone usually carries. When we get into the 19-nors they do so much more outside of the AR and that’s what makes them so effective. The increased mineral retention means your muscle cells are super hydrated and we all know a hydrated muscle cell is more anabolic. The synovial fluid increase means fewer aches and pains and probably more overall physical activity. The preferential binding affinity it has for the AR means stronger stimulus and “well being/alpha” feelings... all this coupled with an ester that ensures blood concentrations are held steady throughout and never drop.
Edit: can’t forget the 5-ar that it leaves alone unlike other anabolics. Which makes it a great pair for gh.
nice I Wii blast a bombs for 6 months!!!yeahhhh!! lol joking, nice finding buddy!!
Don't do that! Lol
fuck no !!D