posted Mon, 01/27/2014 - 12:27
1272
+ 1 Grab Tudca while you can!
ad
I've been interested in Tudca for quite some time and through my research I've found some interesting news. This could happen in 6mo or 2 years, but sometime in the near future it is said that Tudxa will no longer be available on the supplement market. There are clinical studies being conducted by a number of pharmaceutical companies, with the ultimate intent of making it's use only available through a prescription. Long story short, if you've done your research as it sounds like the pharmaceutical companies have, you better start hoarding Tudca now before it's taken off the shelves.
- Bookmark
- 1
- 0
AnonWell shit, this certainly changes my plans
AnonYeh I had some serious plans for it as well, but was told by a manufacturer that in fear of FDA/lawsuits and waste of product, they would not manufacture a product with it. Those companies that have it out there currently, are basically rolling the dice of having the final decision to have it's use banned in dietary supps come down at anytime. I will say you can get this stuff easily from China ranging as low as about $500/kg to $1800kg depending upon total quantity, purity, GMP cert etc. To me this would be a very good thing to go ahead and stock on a site like eroids bc who knows how much the pharm companies are gonna charge for it, not to mention getting a Dr's scrip...it is apparently a wonder drug for much more than just the liver.
Good observation, I am also watching for AICAR to get picked up by US Pharma.
I would if I wasn't broke. I do see it starting to dwindle.. could we still purchase it as a research chemical maybe?
AnonChina produces it like crazy, so im sure someone will order the raws and continue making something, but the price will go up im sure. If you can afford it though, it seems that the Pharm companies recognize how effective it is too, so get it while u can
I have been reading about that stuff. Looks like big pharma is trying to buy it all up and patent it. Good business idea but still; it's not cheap at all and wait til big Pharma gets it.
here is the link to it
http://examine.com/supplements/Tauroursodeoxycholic+Acid/
The most interesting part is taken from this excerpt from the link:
TUDCA has been shown in vitro to increase protein content and mRNA levels for the deiodinase enzyme D2 in cells expressing this protein normally; this protein converts relatively low-activity thyroid hormone T4 to T3, and incubation with TUDCA was able to double protein content of the enzyme and increase T3 levels at concentrations between 100-800uM, reaching three-fold increases at the highest level.[52] Although the delayed response to max potency and prior evidence that deiodinases are regulated post-transcriptionally,[58] the authors noted that the increase in deiodinase mRNA (Dio2) makes it unlikely that the effects seen are secondary to protein stabilization.[52]
When fed to mice at 0.5mg/kg bodyweight, TUDAC was unable to induce fat loss over 7 days but induced a change in respiratory quotient by 5% towards using fatty acids as substrate.[52] Serum levels of T3 and T4 were unchanged in these animals, suggesting localized usage of T3 or a mechanism independent of thyroid hormones.[52] Another report noted small but statistically significant decreases in body weight in mice over 15-30 days, but did not specify dose of TUDCA used.[8] It is possible that these effects are through increasing activity of the D2 receptor, which has been demonstrated in animals with 0.5% cholic acid in the diet that induced similar effects such as an increase in metabolic rate alongside a decrease in respiratory quotient (indicative of a greater % of energy from fatty acids).[59]
These mechanisms may be relevant to humans due to muscle cells expressing the same D2 receptor, and at least cholic acid has been found to increase human myocyte mRNA of this receptor (TGR5) and similar trends were found with all tested bile acids.[59]