Male and Female dosages are different, but have you (or your lady) start low like 5mcg and work your way up by 5mcg every 2 to 3 days, until sides get to unbearable OR until you get to 50mcg-70mcg (for females) and about 100mcg-130mcg for males. You don't want to go past the maximum recommended dosages, I know people who have but it increases your chances to have cardiac arrest by like 100. A lot of people say pyramid down to get your body used to losing it. I like to use clen to reset my caffeine tolerance also. Hope this helps.