I learned that natural IGF levels can vary significantly. Most people get it done once and never do it again so they don’t know this. I almost did the same. I first checked mine in my mid 20s before my first run on GH and it was 124. Better than yours but still really low for someone my age. And I ran GH for years and eventually took a break from everything. I was ready to jump back on GH last summer and for some reason decided to check my baseline again. I figured if I was 124 in my mid 20s then abused GH for years I’m probably gonna be way lower now a decade later but much to my surprise I was 304. Technically out of normal range. So what I’m getting at is based on my experience I wouldn’t put too much stock into 1 test. If you’re really curious test again in a couple weeks or something.

But any strain on your liver is going to impact your igf-1. Likely significantly. If you have non alcoholic fatty liver disease that’s definitely going to cause you to produce less igf-1. The systemic IGF-1 we measure in blood tests is produced by the liver. Luckily systemic IGF-1 seems to be worth fuck all. I’m a high responder to GH and have always had very high igf-1 levels on GH but never really got a whole lot out of GH in terms of muscle growth. On the other hand there’s guys who get very little igf-1 increase on GH as measured via blood test but get sick results. Local IGF-1 is what’s important. So if you’re planning to run GH don’t be surprised if you don’t see a huge spike. That doesn’t mean you’re not going to get good results. I would still expect some increase though. But you may not break 200ng/ml, but it doesn’t seem to matter. Local IGF-1 is where the magic happens and that can’t be measured by blood test.

Yes mate I believe high Liver enzymes often go hand in hand with low IGF1 serum levels. Seen it many times on SI pages where guys running HGH kits will produce low IGF1 results and therefore accuse the HGH kits of being shit. Then the HGH kit is tested itself and found to be fine. It stands to reason since IGF1 is directly produced in the Liver. So if your liver is impaired even slightly then this result won't be as good. Thats why it can often be better to just run IGF1 - LR3 instead of HGH as this will bypass the liver and just produce a constant higher IGF1 level over 24 hours rather than a HGH produced impulse that only lasts 30 minutes at a time, and is dependant on your Liver health.

When you say your ALT and AST are naturally high - what kind of levels are you talking of?