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FourYrs
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Late-Cycle Bloods from Marek

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I'm three months into this cutting cycle, down from 205 (first photo) to 190 (second photo). Cycle began with 4iuGH nightly, 350 test, 280 primo, 4mg Reta, 70 tren ace which I titrated up to 100mg. I dropped the tren after 8 weeks (it was a trial run to see how I respond to the compound), and added 200 mast and 20mg anavar preworkout. Bloodwork at the end of the tren phase was good, and got another round of bloods last week. Most indicators improved (e.g., HDL, however modestly, liver enzymes, surprisingly given the introduction of the orals). Plan is to continue through the end of the month and then settle into a health phase, with TRT dosed at 140mg/week.

I went with Marek Diagnostics for blood work. Process was smooth - the build your own panel was affordable (relative to Labcorps), and I had a promo code. They use QuestLabs for processing, which is conveniently located. I went with a pretty basic panel. I usually use my insurance-covered, TRT-doc mandated panel for my cadillac panel - ApoB, GGT, Cystatin C etc. I would recommend their services. Bloods follow:

TESTOSTERONE, FREE, BIOVAILABLE AND TOTAL, MALES (ADULT), IMMUNOASSAY

Analyte Value

TESTOSTERONE, TOTAL, MALES (ADULT), IA 1171 H Reference Range: 250-827 ng/dL

ALBUMIN 4.4 Reference Range: 3.6-5.1 g/dL

SEX HORMONE BINDING GLOBULIN 5L Reference Range: 10-50 nmol/L

TESTOSTERONE, FREE 491.4 H Reference Range: 46.0-224.0 pg/mL

TESTOSTERONE,BIOAVAILABLE 989.3 H Reference Range: 110.0-575.0 ng/dL

LIPID PANEL, STANDARD

Analyte Value

CHOLESTEROL, TOTAL 101 Reference Range: <200 mg/dL

HDL CHOLESTEROL 27 L Reference Range: > OR = 40 mg/dL

TRIGLYCERIDES 52 Reference Range: <150 mg/dL

LDL-CHOLESTEROL 61 mg/dL (calc)
Reference range: <100

Desirable range <100 mg/dL for primary prevention;
<70 mg/dL for patients with CHD or diabetic patients
with > or = 2 CHD risk factors.

LDL-C is now calculated using the Martin-Hopkins
calculation, which is a validated novel method providing
better accuracy than the Friedewald equation in the
estimation of LDL-C.
Martin SS et al. JAMA. 2013;310(19): 2061-2068
(http://education.QuestDiagnostics.com/faq/FAQ164)

CHOL/HDLC RATIO 3.7 Reference Range: <5.0 (calc)

NON HDL CHOLESTEROL 74 Reference Range: <130 mg/dL (calc)
For patients with diabetes plus 1 major ASCVD risk
factor, treating to a non-HDL-C goal of <100 mg/dL
(LDL-C of <70 mg/dL) is considered a therapeutic
option.

COMPREHENSIVE METABOLIC PANEL

Analyte Value

GLUCOSE 60 L Reference Range: 65-99 mg/dL

Fasting reference interval

UREA NITROGEN (BUN) 24 Reference Range: 7-25 mg/dL

CREATININE 1.55 H Reference Range: 0.60-1.29 mg/dL

EGFR 58 L Reference Range: > OR = 60 mL/min/1.73m2

BUN/CREATININE RATIO 15 Reference Range: 6-22 (calc)

SODIUM 137 Reference Range: 135-146

1/3 9/7/26

POTASSIUM 4.9 Reference Range: 3.5-5.3 mmol/L

CHLORIDE 104 Reference Range: 98-110 mmol/L

CARBON DIOXIDE 27 Reference Range: 20-32 mmol/L

CALCIUM 9.1 Reference Range: 8.6-10.3 mg/dL

PROTEIN, TOTAL 6.2 Reference Range: 6.1-8.1 g/dL

ALBUMIN 4.3 Reference Range: 3.6-5.1 g/dL

GLOBULIN 1.9 Reference Range: 1.9-3.7 g/dL (calc)

ALBUMIN/GLOBULIN RATIO 2.3 Reference Range: 1.0-2.5 (calc)

BILIRUBIN, TOTAL 0.7 Reference Range: 0.2-1.2 mg/dL

ALKALINE PHOSPHATASE 26 L Reference Range: 36-130 U/L

AST 29 Reference Range: 10-40 U/L

ALT 37 Reference Range: 9-46 U/L

CBC (INCLUDES DIFF/PLT)
Analyte Value

WHITE BLOOD CELL COUNT 5.7 Reference Range: 3.8-10.8 Thousand/uL

RED BLOOD CELL COUNT 4.05 L Reference Range: 4.20-5.80 Million/uL

HEMOGLOBIN 14.0 Reference Range: 13.2-17.1 g/dL

HEMATOCRIT 41.8 Reference Range: 39.4-51.1 %

MCV 103.2 H Reference Range: 81.4-101.7 fL

MCH 34.6 H Reference Range: 27.0-33.0 pg

MCHC 33.5 Reference Range: 31.6-35.4 g/dL

RDW 13.7 Reference Range: 11.0-15.0 %

PLATELET COUNT 234 Reference Range: 140-400 Thousand/uL

MPV 9.1 Reference Range: 7.5-12.5 fL

ABSOLUTE NEUTROPHILS 3779 Reference Range: 1500-7800 cells/uL

ABSOLUTE LYMPHOCYTES 1488 Reference Range: 850-3900 cells/uL

ABSOLUTE MONOCYTES 382 Reference Range: 200-950 cells/uL

ABSOLUTE EOSINOPHILS 23 Reference Range: 15-500 cells/uL

ABSOLUTE BASOPHILS 29 Reference Range: 0-200 cells/uL

NEUTROPHILS 66.3 %

LYMPHOCYTES 26.1 %

MONOCYTES 6.7 %

EOSINOPHILS 0.4 %

BASOPHILS 0.5 %

ESTRADIOL,ULTRASENSITIVE, LC/MS
Analyte Value

ESTRADIOL,ULTRASENSITIVE, LC/MS 20 Reference Range: < OR = 29 pg/mL

What stands out to me:

My SHBG is crushed, resulting in very solid free test and bioavailable test numbers. I was surprised my total test was not higher, considering I usually run around 950mg when I'm justr running 140mg/week. Estradiol is low, but I'm not having symptoms so I'm good with it. Glucose is a puzzle. I was not fasted - I had eaten my postworkout meal about an hour before the test. One hypothesis: insulin resistance is crushing both SHBG and responsible for my borderline hypoglycemia because my pancreas is working over time and pumping insulin after I eat, resulting in a glucose crash. Another hypothesis: the combination of reta and intense glycogen depletion contributes to rapid postprandial glucose absorption. I'm not experiencing hypoglycemia, and on my last three tests my glucose an hour postprandial has been in the 60s, well before I implemented any GH, suggesting the latter. What do the wise minds gathered here think?

I appreciate your insights and any observations you have on bloodwork and other bioindicators! Thanks!

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Yuzy2784's picture

Hey man, just a heads up I think your name was copied over from your blood work right under the kidney markers.

FourYrs's picture

Whoops… thanks for the catch!

In a promo × 1
Yuzy2784's picture

Anytime man, what’s the deal with the EGFR? Have you got a recent GGT to check into it?

FourYrs's picture

GGT was good to go at the end of July when I checked it. I am not sure what to make of the EGFR. I figured checking cystatin c on my next visit would be the proper follow up.

Also, my macrocytosis is congenital- I have had it all my life, since well before taking any PEDs.

In a promo × 1
Yuzy2784's picture

I mistyped sorry on night shift was half asleep. I meant to ask about a Cystatin C.

1981ge's picture

EGFR is a calculation based on Creatinine, age, and sex, but can also be calculated based on Cystatin-C. Since you only pulled Creatinine this go around it was calculated based on Creatinine. A low EGFR in this case is just another way of telling you your Creatinine is high. If you aren't concerned about the high Creatinine (and I probably wouldn't be so long as it is consistent with previous bloodwork), I wouldn't be concerned about the low EGFR in this scenario.

Cystatin-C and Cystatin-C based EGFR are much more applicable to our population given that creatine intake, high protein, and heavy resistance training can all result in elevated Creatinine even if the kidneys are fine. I would only pay attention to Creatinine if there was a trend of increasing levels over several blood panels.

I'm not sure GGT would have any bearing on Creatinine/Nephrological markers though. From my understanding GGT is primarily a hepatic/pancreatic marker for liver health/bile ducts. Maybe I'm missing something here and GGT does have nephrological implications?

In a promo × 1
FourYrs's picture

I think you are correct. I have read that GGT is an indicator of liver health, and a better diagnostic for our population than AST/ALT for the well-established reason that having substantial muscle mass and training hard can transiently elevate the latter. My last GGT was 18, and ALT/AST slightly higher than they are now, but still in range. I don't believe GGT has any bearing on kidney function.

I appreciate the clarification on EGFR. It is more or less consistent with pre-cycle levels, and with my pre-TRT levels going back 5 years. I'm not worried about creatinine (also consistent), but it has been about a year since I last checked Cystatin C, so I will be running that one during my health phase to see if the last year has done any kidney damage. Considering my BP has held steadily in range and my hematocrit has also remained healthy I'm not too worried about it. I have read that much AAS correlated kidney is secondary to blood pressure: high blood pressure damages the nephrons. That's one theory why consensus has held that boldenone is nephrotoxic since so many guys get hematocrit and BP issues on it.

Thanks for the info!

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