posted Tue, 05/03/2016 - 18:52
2586
+ 1 Why does clomid make you so tired
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Started my pct. I forgot how bad it sucked. I had a post that before the site crashed and some guys showed support.
But I have a new question. Why does clomid make you so tired?
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update: I stopped taking taurine at night 500 mg. I feel less lethargic.
What is Your pct ? Is it nolvadex and clomid .
The clomid doesn't make you tired . The nolva does it . Specially week 3 and 4 . You start losing weight . Your testeron just about to start recover . Clomid has nothing to do with makes you tired during pct . This why I read an article over creatine during pct help .
Because clomid acts as an estrogen receptor agonist in certain tissues and as an estrogen receptor antagonist in others, the estrogenic effects can cause you to feel lethargic, moody, etc. The lack of testosterone during pct as well as the elevated cortisol levels also do not help this at all
how does estrogen make you tired?
Been a long time since I looked into this, so I may have to research more and correct this later. But the thyroid, gonadal, and adrenal axis all have some degree of influence over each other. So when the gonadal hormones are screwed up it can screw with the others as well which can make tiredness worse. And I believe it was actually low estrogenic symptoms that's been linked to the lethargic component if I remember right. I'll have to get back to you on the real specifics though it's been too long since I looked at those studies
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3226892/
So appears the reason would be estrogen is critical to maintaining some neurotransmitters, specifically serotonin. Serotonin is crucial to maintaining a normal sleep cycle and alertness. Which is part of why menopausal women get fatigued so easily.
I know this is also the case with androgens as they alter your brain neurotransmitters as well. Especially tren which is why it's known for serious aggression, insomnia, etc. It lowers serotonin which is partly responsible for keeping you calm and empathetic
+1 dude, can I give plus 2?
this was great!!!
is there such thing as a seratonin agonist? the only things I could think of that affect seratonin would be anti depressants and adhd medication. i don't think those make more seratnonin but kind of slow down the transmission so it stays in certain parts of the brain longer.
Lol no problem I'm a bit of a science nerd so I love this stuff.
And there are serotonin agonists but they're usually used for migraines. My girlfriend has a prescription for relpax for instance which is one. And the anti depressants are SSRIs or selective serotonin reuptake inhibitors, so they keep your neurons from being able to reabsorb the serotonin back in vesicles for later exocytosis. They keep stimulating the receptor on the receiving dendrite over and over. Adhd meds do a similar thing but with dopamine. Way different results obviously.
The two natural supps I know of that increase serotonin are St. John's wort and 5-hydroxytyptophan. I believe they've both been proven to actually work but not 100% on that. Trytophan biochemically can be converted to serotonin and niacin I know for sure. And I'm pretty sure we can also derive melatonin from the serotonin after that. The St. John's wort however I have no clue how it would work
If you want more serotonin try take some 5-HTP. Nice an natural. That said I'm not sure it will make you feel less tired. It helps promote sleep in some people who struggle with this for example.
+1
How much are you taking?
50 mg. not concerned with how to fix it. I just want to know the mechanism of action that leaves me tired.
Drink coffee and pop a B12 and/or take your clomid and nolva at night before bed. 50mg of modafinil may help.