+ 9 Muscle Cell Saturation
Firstly I want to state that this is a FACT of human physiology. Not what may or may not happen because a piece of literature or two say so.
Now bear with me, because I want to make sure everyone understands this.
I'm sure you're familiar with how people say that fat cells never "disappear", only shrink? Well this is obviously true. The fat cells you gain will only shrink in size but will always be present in your body - Along with all the necessary cellular components of the cell to function (nucleus where the genetic information is held, ect).
Fat cells are obviously specialised cells geared towards storing adipose tissue. And since the genetic information "hardwired" to storing fat will always be retained (as the cell does not disappear, only shrinks), gaining fat will always be EASIER for those who were previously obese, and have a greater number of fat cells still present in their body.
This is a legitimate reason why people are encouraged to lean bulk and not dirty bulk.
Anyway, its almost the SAME thing with a muscle cell (specialised cell). I'd like to make it clear that this is also THE MUSCLE MEMORY PEOPLE KEEP TALKING ABOUT. Muscle memory is a FACT and all you need to do is understand this little mechanism of human physiology to understand that it is.
Above I also said "Almost" the same thing, as we know that you don't "gain" muscle cells under normal conditions (what HGH may or may not do aside) - You're stuck with the amount you were born with.
But the muscle cell, like the fat cell, can shrink in size, but it will never "disappear" and will retain all its cellular components necessary to its function.
Now when you use steroids, there are only a certain amount of AR in the body. Once your body uses up all the AR, it will do something very intelligent - CREATE MORE androgen receptors within the muscle cell.
Therefore, whenever a satellite cell fuses with a muscle cell, it donates an androgen receptor. Steroids increase the rate at which these satellite cells fuse.
Now, because of this, if you ever stop training and lose the size of your muscle cells, you will always retain the cellular components of the muscle cell. That includes the AR and any extra ones that the body has produced along the way. This is muscle memory in the flesh.
And obviously, the bigger the person, the more AR they have.
Now I know what you're thinking and yes, from this theory, we can confidently deduce that the body becomes UPREGULATED from many years of training and steroid use (Isolated or together). Meaning, there is NO SUCH THING AS YOUR FIRST CYCLE IS YOUR BEST - THIS IS A PSYCHOLOGICAL ISSUE. Your body will only become BETTER are processing steroids, whether they be your natural production or exogenous.
However, even though the bodies growth is not regulated through the androgen receptor, it IS THROUGH OTHER MECHANISMS (Myostatin for one, being a huge one that everyone should know about). This is why we can't keep growing to 500lbs, 5% or 300lbs, 10% from using everything under the sun for a year. I'm just saying that the AR does upregulate, not downregulate, and is not the source of growth prevention but promotion instead.
This is why Bodybuilding will always, no matter what, take dedication, patience and time.
So that's why a pro, or someone who is OR WAS in the past bigger than another person, will always have more AR. Effectively, they have the ability to utilise more steroids and benefit more off smaller dosages VS someone smaller.
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Great post!
+1
Great inspiration!
trainbrain is the real deal!
Gator
Buildbigger86Train, Absolutely an amazing post!! Such detailed informed information and also a very comprehensive read.
Thanks again plus 1
Very interesting! Thanks for sharing..... +1
nice, +1
Anonlove this, definitely one to read again and again
Fantastic write up +1
Myostatin inhibitors and follistatin peps are something that i'm looking into currently.
Great and easy to understand logic behind this post.
AnonSo theoretically overdosing on 'ar' binding compounds would promote more ar? Obviously over overdosing would lead to more sides than its worth but if one could find the sweet spot lets say.. He's ar were 'drenched' at 800mg test per week lets say he ran 810mg per week this would directly stimulate the body to produce more ar and in turn promote his future muscle building capabilities?! Is that wat ur saying... If he body senses its drenched its ar it will build more?!
So if i run maaaassive fkn amounts of test all year round ill be a beast like u bro!? Ill just need tk double whatever ur dosing
yiiiew
I don't think it works like that. I'm sure there is a certain amount of receptors that must be occupied before your body begins to synthesize more. Or maybe it's an ongoing process, who knows. Either way remember what trainbrain said: AR is not the only mechanism for growth
Thanks for your time
hard work is never wasted
Is this scientific fact or theory? Either way interesting information.
This somewhat connects to the theory of different compounds fighting for the same receptors, because (and correct me if i'm wrong) if when the AR fills up your body just creates more receptors, then there should never be an issue with using any two compounds together (e.g tren/test)
Awesome write up, thank u for posting man