posted Sat, 11/29/2025 - 07:18
227
Undeconoate Test bypass Liver
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Most people always say Ester doesn't matter. Other then for pinning. What makes undecanoate different then other esters? Appears if taken orally it bypasses the liver and is lymphatic. Why don't other esters and why does this ester possible change how we think about esters?
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It all has to do with the carbon chains and it's a long fatty acid chain. Undecanoate is non polar and fat soluble and only the oral form bypasses the liver but it has to be taken multiple times a day if oral because of its fast absorption.
"Absorption Mechanism: When taken orally with a meal containing fat, the drug is incorporated into chylomicrons, which are lipoprotein particles that transport dietary lipids. Instead of entering the portal vein which leads directly to the liver, these chylomicrons are absorbed into the intestinal lymphatic vessels."
Injection form lasts a lot longer than oral because it is suspended in oil which is then slowly broken down by the body and the ester is slowly released.
Other esters go through the portal vein directly to the liver which is first pass metabolism and the liver breaks it down quickly making oral form unsuccessful.
Finding out there is alot more to esters than it just being a "timer"