+ 1 *_____ Terminal, Active, half-life of our compound??!____*
I could have sorted this out with self research, however many of our members have real world experience with compounding PEDs.
I was under the impression for YEARS half life of the most noted compounds ,, Test cyp-7 days ,, Tren E-12 days..
Was the gold standard.
Not but a couple years ago all the literature has change and now Tren ace has gone from a 3 day half life to a 1 day. Tren E went down from a 12 day to a 4.5 day.
I used to plan many of my cycles with less pinning back in the day , is this a ploy utilized such as “creatine loading phase” ?get through your product quicker so you come back for more.
Or is there legit science to this, again , I probably could’ve researched this myself; I want to hear what the 40yr old + side of the community has to say about these half lives ..
Thank you ----
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I've always thought these Statistical Half Lives of compounds in Oil (& tablets) are complete Bullshit and way out in reality. I realised in the early days that Propionate was nowhere near as long as stated because when injecting it EOD I would always feel like a junkie on a comedown on the non-pinning day. Thats when I switched to ED injecting and never looked back. The Enanthates are nowhere near that long either. I read in a study several months back that when a subject was injected with 200mg of Test prop, 20 hours later only 100mg was left in the bloodstream, so the half life is clearly less than a day. I would say the half life of Acetate is around 10 to 12 hours. The more you use gear bud the more you will get a feel for where levels are, you will realise what works best for you to keep your levels stable. I think a lot of the time half lives are being confused with Total active life in the blood - which is fives times as long as a compounds half life.
"That kid’s long gone, and this old man is all that’s left. I got to live with that. Rehabilitated? It’s just a bullshit word. So you go on and stamp your form, sonny, and stop wasting my time. Because to tell you the truth, I don’t give a shit.
Shawshank!
Great way to tie it altogether press !
Yep it definitely changed. Only true answer is blood graph charts in regards to testosterone esters
BysandtrysIt's also going to vary a good amount for each individual. Everyone's got their own unique physiology
Is there any literature to back it? I’m not coming at you by any means and I didn’t stop to think about clearance rates, just wondering if there’s some sort of test,
Albeit blood, dna, saliva that tells us what compounds would do the most for our unique makeups
As of recent I did take a genetic test to see which antidepressants would have a noticeable effect vs the ones which don’t jive with my biological
Maybe it’s all snake oil smoke an mirrors
BysandtrysIt would have to be an N of 1. Like @BlindAlligators mentioned doing frequent blood tests, utilizing different esters to see how it effects serum concentrations at different time points.
There are some genes which can change the speed of how you metabolize different esters. Some people respond better to Enth vs Cyp and vice versa.
Also of note, carrier oils will affect the half life significantly. Test E in Castor oil has a much longer half life vs MCT oil due to the viscosity.
The genetic SNPs have some correlation with medication response, but there's still a lot of unknowns in that area so I would take that with grain of salt.
Yep that's true what you say about the viscosity of oils affecting half life. A buddy of mine on here named Serra jujutsu proved that with his pharma test U in castor oil vs Test U in mct oil.
Duh I didn’t even grab ahold of this MCT oil craze, I do notice even with my longer water gear I have to pin more frequently, bring back the GSO and safflower oil.
I get tired of having to pin test cyp five times a week
GSO all the way
Even more reason to use Axleabs, you can at least choose that option for most of your major compounds
Theoretically you could take serum testosterone tests every day for 30 days or something and interpret data from that. Non-standard hormone levels would require testing specific to that hormone. There’s probably real medical research from whoever first created each steroid but I’ve never seen the data