ultimate domination's picture
ultimate domination
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+ 3 arimidex vs aromasin on cycle?

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which is better?

kibby's picture

STICKIE!!!!

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back40's picture

Awesome post.

mike890's picture

arimidex is a potent sulfatase inhibitor, its a weak aromatase inhibitor.
Aromasin is a moderate sulfatase inhibitor and a potent aromatase inhibitor.

aromasin has a preferable suppression profile for males, especially males using exogenous steroids.

Reccomend AIFM or AROMASIN, with letro on hand. (letrozole is a potent sulfatase and aromatase inhibitor)

fusebox's picture

And banned

Shredbrah's picture

I prefer adex but I'm always paranoid about water retention so I take 1mg a day.. Im slowly trying to taper down to only .5 mg a day

HexLover's picture

My first time to run dex. how much should i take with my cycle? Test cyp and tren ace.?

Pericu's picture

Are you really digging up a 4 year old thread?!

jfablio's picture

aromasin is the 'nuclear option'; it's very effective at quickly killing off nearly all available aromatase enzyme sites. If you overdo it though there are some shitty side effects; cracked, dry lips and fucked up mucus membranes. Still, Aromasin is my go-to AI, not arimidex.

Bigguns2014's picture

Hi there

I know was posted 4 years ago

What sides do u get with mucus membranes ?

As use aromasin for my trt

And seem to get a lot of mucus in my throat and nasal to the point it makes me
Sick

Is this a side effect of
Mucus membrane ?

So it is a low estrogen problem ?

Gregy's picture

The two best AI's to get are Aromasin or Arimidex. You should low dose those so you don't get unwanted side effects like joint pain or lethargy. Remember, your body needs some estrogen.

12.5mg Aromasin 2x a week or 0.25mg Arimidex 2x a week should be plenty and will help regulate estrogen levels while increasing overall testosterone.

Exemestane, sold under the name Aromasin? by Pfizer, is an orally available suicidal aromatase inhibitor. <This sentence describes exactly why exemestane is the king of anti-e's for bodybuilding purposes.

Because exemestane is steroidal this gives it a favorable estrogen suppression profile and confers a few really awesome benefits over other anti-estrogens both on paper and in real experience. Steroidal anti-estrogens have the benefit of being lipid-friendly and they all lower sex hormone binding globulin which increases the ratio of free to bound testosterone, which as many experienced BB'ers know can have a relatively profound positive impact on gains.

I think it is important to understand how drugs work in order to properly dose them, exemestane is a suicidal aromatase inhibitor, this means that it binds with aromatase enzymes and as it does so permanently disables the enzyme and destroys it. Hence the "suicidal" this chemical is like a kamikaze pilot out to destroy your aromatase enzymes which is what makes it so special.

Exemestane's half life in the male body is actually very short (~9 hours) and it is quickly eliminated, however, since as soon as it enters your bloodstream it quickly destroys 80-90% of the aromatase enzymes present in your body, it is effective in maintaining significant reductions in estrogen for up to 72 hours after a single 25mg dose. Estrogen levels only begin to rise again after your body has begun to make new aromatase enzymes to replace the ones destro by exemestane.

There is a great study on the pharmacokinetics of exemestane in men which found the following:
-24 hours after one 25mg dose estrogen levels are reduced by 70-80%
-72 hours later estrogen levels are still 40% below baseline even though the drug itself is almost completely eliminated
-120 hours after initial dose estrogen levels return to baseline (without rebounding)

this means that you can find the timing and dosage that works for you, i've seen some guys recommend between 25mg ed and 12.5mg e4d, and you can see why both are effective while providing different levels of estrogen suppression, and it is this flexibility that makes exemestane such a versatile anti-e.

BUT WAIT, there's more. Aromasin is also a badass PCT drug! In males exemestane was found to increase total testosterone by ~60% after 10 days @ 25mg/day, however the same study found that while it increased total testosterone by 60% free testosterone was increased by over 100 percent! that's right, it DOUBLES bio-available testosterone (natty of course).

I can tell you this much, when I take Aromasin for PCT the results are dramatic, honestly my libido is never absent at any point during PCT and I absolutely feel great within a matter of days, and this is taking 12.5mg ed, the only side effect i notice is stiff joints and other stiff areas

the good:
-powerful aromatase inhibitor capable of stopping gynecomastia completely on its own (for aromatizing compounds)
-has powerful bloat-reduction effects
-lowers sex hormone binding globulin , increasing free test & makes all other anabolic steroids more bio-available (read: more gains)
-can actually boost libido on and off cycle
-increases igf-1
-NO adverse changes in lipid profiles for men (granted if you are using it on cycle this may be different)
-is NOT liver toxic
-no estrogen rebound

the bad:
-typical aromatase inhibitor issues here include stiff joints and possibly lethargy
-more difficult to come by than a-dex or letro

Appropriate uses for Exemestane:

1) on cycle estrogen control - that's right, any and all estrogen related problems can and should be corrected with this compound, from gynecomastia to acne to bloat exemestane is a panacea, run it at 12.5mg e4d for gynecomastia protection and bloat control, or run it at 25mg ed for pre-contest or for gynecomastia sensitive individuals or moon face. the beauty of Aromasin is it's okay to use preventatively and not just as spot treatment for gynecomastia as it doesn't hurt gains nearly to the degree that other anti-e's do, i'd still recommend using anti-e's only if you need them, but if you must use one throughout your cycle, you couldn't pick a better compound to use.

2) PCT. Aromasin is the premier PCT drug in my experience... honestly PCT is kind of fun with Aromasin (maybe that's a stretch) but it's a breeze compared to clomid/nolva and significantly better than a-dex (more powerful and fewer sides) it works excellently with hcg and keeps the extra aromatization from the hcg injects at bay (you can even run higher dosages of hcg above 500iu/inject) and another bonus is since it's safe and comfortable to run for longer periods of time, you can stretch your PCT out to 6 or 8 weeks for suppressive cycles to make sure you get everything back in full working order

3) gynecomastia reversal - in conjunction with a selective estrogen receptor modulator (raloxifene or Tamoxifen) and/or a dihydrotestosterone derived compound Aromasin can be effective in reversing/reducing existing gynecomastia

4) off cycle testosterone boost - sometimes if i dont feel like running a cycle but still want a little extra kick i'll take 25mg EOD for 4-6 weeks, gains aren't improved all that greatly but significantly, but i do it more for the libido/mental effects anyways.

5) hypogonadism - so you're getting older, you've been cycling since you were 21 and your natty test levels just never get back in the good range, but you don't wanna go HRT??? Aromasin will get you back in the game without having to take the plunge for HRT.

Aromasin (exemestane) is a steroid-al AI - an irreversible aromatase inhibitor ... great for controlling estrogen "during cycle" and "PCT"
ABSTRACT FROM JOURNAL OF CLINICAL ENDOCRONOLOGY AND METABOLISM

Suppression of estrogen, via estrogen receptor or aromatase blockade, is being investigated in the treatment of different conditions. Exemestane (Aromasin) is a potent and selective irreversible aromatase inhibitor. To characterize its suppression of estrogen and its pharmacokinetic (PK) properties in males, healthy eugonadal subjects were recruited. In a cross-over study, 12 were randomly assigned to 25 and 50 mg exemestane daily, orally, for 10 d with a 14-d washout period. Blood was withdrawn before and 24 h after the last dose of each treatment period. A PK study was performed (n = 10) using a 25-mg dose.

RESULTS :

The 25- and 50-mg doses of daily exemestane had comparable effects in suppressing circulating estrogen concentrations, with 38 ? 24% (mean ? SD; P = 0.002 vs. baseline) and 32 ? 29% (P = 0.008) decreases in estradiol concentrations, 71 ? 12% (P < 0.0001) and 74 ? 12% (P < 0.0001) decreases in estrone concentrations, and 45 ? 27% (P = 0.004) and 51 ? 20% (P = 0.02)

BUT THERE'S MORE

There was an increase in circulating testosterone concentrations after both 25 mg (60 ? 58%; P = 0.001) and 50 mg (56 ? 48%; P = 0.003) exemestane. Androstenedione concentrations were increased as well after 25 mg (32 ? 36%; P = 0.004) and 50 mg (47 ? 59%; P = 0.052) exemestane, respectively (Fig. 1Go and Table 2Go).

SHBG concentrations were decreased by 21 ? 7% (P = 0.0003) and 19 ? 39% (P = 0.18) at 25 and 50 mg exemestane, respectively.

Free testosterone concentrations were increased by 117 ? 74% (P = 0.0001) and 154 ? 95% (P < 0.0001) at both doses, due to the decrease in SHBG and the increase in total testosterone.

THE ICING ON THE CAKE !

There were no changes in circulating serum triglycerides, cholesterol, or LDL or HDL cholesterol concentrations with either dose of exemestane.

Superplex1's picture

Deleted post

spartacus91's picture

If that post is not taken from some other website and its your own write up thats some great info

MegaT883's picture

I think you hit the nail on the head. It's which works best for you. For me it's Aromasin. I just feel better while running it. I've done them both. Adex just dries me out to much and causes my shoulder joints to hurt. They both get the job done.

j223's picture

adex is better imo on cycle

aromasin pct

Drywallstar's picture

Would 12.5mg eod of asin be suggested for 100mg prop and 75mg npp eod? Starting week 2 ofcourse along with caber at .5 e3d.

gatorbits's picture

You should start a thread bout it to get a more focused opinions on your topic
But I will say that is to much cabergoline for that amount of NPP
You need no more then 0.25mg twice week, maybe even only once per week at that doseage
I'm assuming your using pharma cabergoline that is accurately dosed that is why I'm stating the lower amount would be suitable

As to Aromasin
12.5 mg eod or maybe even 6.25mg eod would be appropriate here
A good rule of thumb is to use the least amount of ancillary to do the job you need

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vocor's picture

"better" may be relative.
Like comparing finasteride to dutasteride for stopping hairloss. Dut is technically "better" because it is stronger and more effective at blocking DHT conversion. But if you get gyno off of it and lose your libido, is it really "better"?
The stronger the compound, the greater the risk/reward.

EBSNW1's picture

None

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mikuni46's picture

Its a difficult cuestion and as always with drugs, everybody is different and will respond different. For me could one be better than others but for you, could the same that I use, be the worst option.

I have only used aromasin and worked great, I will try Arimidex and compare the feelings

EBSNW1's picture

Aromasin is the much better AI. I'll explain exactly why:

My specific preference of aromasin is because just 25mg decrease aromatisation by 98% for a period of 5 - 7 days. In addition, it shows a very positive effect on LH and FSH, as well as an increase in gonadotropin, making it great not only on-cycle but also for PCT.

Furthermore, it also increases IGF-1 levels, which is a much desired effect. Moreover, it is less harsh on blood lipids than other AIs.

These qualities make it superior to other AIs, and if I was taking it during a cycle to stop large amounts of gear from aromatising it would be my only choice.

However, if you are doing a moderate cycle of 500mg/week of test, I would not use any AI at all as the high estrogen does have an anabolic effect, unless of course you are retaining way too much water or developing gyno symptoms. Normally a high dosage of zinc in excess of 100mg should be enough for this kind of cycle.

Funnily enough, dosages in excess of 400mg/day of aromasin have shown to act slightly androgenic, which is not relevant though as the price is quite high.

Don't listen to the "I used it and liked it so its better" crowd. Look at the science behind compounds and then decide which is best for you.

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spartacus91's picture

Great post bro,am going to run adex on cycle and aromasin 2 week pre pct and in pct so this makes me happy to hear. pct is not sounding so bad no more... Smile cheers

Fullypumped's picture

Whats up Bro I sent u a friend request. I need help figuring out dosages for a anti estrogen while on cycle. I am very prone to Gyno and I am looking into aromasin. Would like your input and help Thank you

sweatnosejackso's picture

What AI would you use if not using an extraordinary amount of gear. Lets say 500mgs test a week and 75mgs tren eod?

EBSNW1's picture

Dude, you can pm me too you know ;)

None would be my answer. Only caber @ 0.5mg e4d for the tren.

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DannySmallwood's picture

What is your dosing preference when running a decently heavy cycle (e.g a gram of test/week or so)? I've heard 12.5 mgs eod is solid. I've also heard 6.25 ed.

I'm thinking about running it for my next cycle, as, like you mentioned, it's easy on the lipids and, as a bonus, doesn't decrease the effectiveness of SERMs like tamox or letro, so you can run it into your PCT and taper down to avoid estrogen rebound.

EBSNW1's picture

12.5mg EOD is a good place to start. You can adjust that if needed. If your pills are hard to split you can just go for 25mg every 4 - 5 days. The half-life of aromasin is sufficient.

You need to see what dosing works well for you.

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Trenabolic's picture

X2 I have alwas ran adex but, there are those who swear by aromasin.

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