Honestly, I consider myself lucky … my appetite doesn’t die on anything. I’ve taken high doses of Tren and orals and still ate like a machine. But from experience, Tirzepatide is by far the strongest appetite suppressant I’ve ever used.

Mechanistically, it’s a dual GIP and GLP-1 receptor agonist:
• GLP-1 slows gastric emptying, reduces appetite, and boosts insulin secretion in response to meals.
• GIP enhances insulin secretion even further, improves fat metabolism, and adds another layer of blood glucose regulation.

Together, Tirz offers a potent combo: appetite suppression, insulin sensitivity, and real body recomposition potential.

But when you introduce Retatrutide, it’s a whole different level. It adds glucagon receptor activation, which:
• Increases energy expenditure
• Enhances lipolysis (fat burning)
• Further improves glucose metabolism
• Has shown potential cardiovascular benefits in clinical studies

That third mechanism makes Reta a triple agonist and the king of peptides right now for fat loss and metabolic improvements. From both what I’ve seen and experienced, Reta is Tirz+, no question.

Both compounds work, they just hit slightly different. Some people feel a bit of elevated BP or heart rate on Reta, while Tirz can cause low energy or demotivation in others. As always, bioindividuality matters, and the only way to know is to run it and track your response.

Either way … both are elite tools if used correctly in a protocol. But for me?
Reta wears the crown. Even though I’m running tirz right now but will order some baboon Reta…