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  • Pentosan polysulfate

  • kh1216   •   Tue, Aug 4th, '15 23:48   •   0 replies, 522 views

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Hey bros I came across this compound in my research for healing all my joints that got screwed up from accutane. I had never heard anyone mention it before so I thought I would bring it up. The research is extremely promising in trials of dogs, racehorses, and people for arthritic joint pain. Been fda approved to treat interstitial cystitis in humans for a while now so it's definitely safe, but research is finding it works very well for joints also. Only side may be a mild anti blood clotting effect.

A couple studies on people:
"In this pilot study, 4 weekly injections of NaPPS were associated with significantly improved duration of joint stiffness and pain at rest compared with controls for 20 weeks after the cessation of treatment, and significantly improved pain on walking and overall function for 8 weeks after the cessation of treatment in these patients with OA of the knee."
Another study:
"under controlled, double-blind con- ditions, 4 consecutive weekly IM injections of NaPPS 3 mg/kg improved joint stiffness, pain at rest, and patient assessment of the effectiveness of treatment for up to 20 weeks after treatment cessation..."

This has also been used in racehorses and dogs for quite some time and has been very effective. Detailed YouTube video on it that cites many animal studies (disclaimer: long and boring but some good info; skip to PowerPoint section if you watch it)

The mechanisms of action are:

(a) Stimulating Chondrocyte Metabolism - resulting in increased production of proteoglycans and healthy cartilage matrix. PPS stimulates synovial fibroblasts to produce increased amounts of high molecular weight hyaluronic acid which results in an increased production of normally viscous joint fluid. Improving the fluid volume and consistency results in more effective joint lubrication and stabilisation, which limits further cartilage damage.

(b) Anti-inflammatory Activity - PPS has an inhibitory action on all mediators of the arachidonic acid cascade. PPS also inhibits the lysosomal catabolic enzymes hyaluronidase, histamine, cathepsin B, and polymorphonuclear elastase. PPS exerts a specific inhibitory effect on mediators implicated in the degradation of cartilage matrix components, preserving the cartilage and preventing the release of the highly inflammatory mediators, thus relieving pain and inflammation.

(c) Fibrinolysis and Lipolysis - PPS is strongly fibrinolytic, stimulating the release of plasminogen activator, and promoting the dissolution of thrombi and fibrin deposits in synovial tissues and subchondral blood vessels. PPS also mobilises lipids and cholesterol in synovial and subchondral blood vessels, which have been implicated in the pathogenesis of osteoarthritis in older animals. These effects combine to increase the prefusion to the joint, which stimulates cartilage healing and repair.

I'm currently running an experiment on myself with this compound. I'm following the usual dosage guidelines of 3mg/kg of body weight. Two weeks in and using alongside bpc-157 for specific site healing for my rotator cuff. So far inflammation in my knees is down significantly. Before they look like tomatoes after I finished squatting and cracked like rice crispies. Elbows feel smoother and more fluid during movements. Nothing overly dramatic, but I'm hopeful after following the four weeks mentioned in all the studies it'll have more improvements and then continue to improve post treatment.
Edit: going to post this in the main forum also to get some more traffic and see if others have used it