+ 2 Anadrol together with Winistrol (Progesterone sides)
Hey guys I'd like to gather some information on Oxymetholone. I heard or read somebody claiming that it's possible to run Anadrol together with Winistrol to avoid progesterone side effects. Anandrol is a very complicated acting steroid imo and I have suffered from it while having estrogen with an ai and prolactin with caber under control and therefore had to stop the administration. Has anybody got experience in that respect or can tell me about the combination? I'm aware that both are liver toxic and normally shouldn't be run together. But what about dosages like 50mg Drol 25 Winistrol for 3-4 weeks, would that be better to handle than just the drol. Or can u avoid getting progesterone sides from Drol by just using it for 2 week on/off bursts? I'm looking forward to gather some new information
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Twigletts these days.
Smh.
Meh childish
Your childish following me around board commenting twiggy.
Rustyhookeri keep skipping your forums because you got a girls name. Dunno why a girl isnt in ladies lounge. Bottoms only? No homo...
Post your goals stats and priors. I dont like double dipping orals.
It's a nick name to be honest my name is Anderson but thanks for the concern, yes I'm a boy. My stats are in my bio but don't know if they matter. I didn't seek for cycle advice just pure information on the synergic effects of both drugs. So you think 50mg/30mg Drol/winny would be worse than just 100mg of Drol concerning the side effects? Bc if not I don't see a problem in running it when I get even less side effects from the drol.
RustyhookerThen im done here. Good luck
You took karma from me?
.
I can't say whether this works or not because I have never run it myself. I have seen it run two times from good friends and they had great results. I will actually be running this in my next cycle but until then I can't really give an opinion on whether it works or not. However it is a very interesting combination.
Nice sounds good. U know wether it prevented the sides from Anadrol?
You didn't explain why winstrol supposedly has this effect. Is it because it lowers SHBG?
Found this:
Stanozolol (winny) stimulates the production of prostaglandin E2 (PGE2) and the matrix metalloproteinases collagenase and stromelysin in human skin fibroblasts but not in rheumatoid synovial fibroblasts. The basis for these differential responses was investigated at the levels of DNA synthesis and steroid receptor binding. Stanozolol inhibited fibroblast growth factor (FGF)-stimulated DNA synthesis in both the skin and synovial fibroblasts, showing that both cell types were capable of responding to the compound. Competitive binding assays indicated that stanozolol bound specifically to both the skin and synovial fibroblasts. Binding of stanozolol to both cell types could be partially displaced by progesterone, indicating that stanozolol binds to the progesterone receptor. Immunocytochemical studies confirmed the presence of progesterone receptors on skin and synovial fibroblasts. However, progesterone failed to elicit any response with respect to collagenase production in either cell type. Nortestosterone, dexamethasone and 17 beta-oestradiol had no effect on binding of stanozolol to either cell type. These results indicate that the inhibition of DNA synthesis by stanozolol is elicited through the progesterone receptor. The effects of stanozolol on collagenase and PGE2 production are mediated by a different receptor, present on skin but not synovial fibroblasts, and as yet unidentified.
http://www.musclechemistry.com/upload/steroid-discussion-forum/31952-win...
On the other hand, this sounds very confusing to me concerning Drol:
" A significant inhibition of thymidine uptake was seen in response to stanozolol in both cell types. The steroids nortestosterone, oxymetholone, and progesterone itself were also tested for their effect on thymidine uptake to determine whether the effects of stanozolol on DNA synthesis were unique. These other compounds also inhibited DNA synthesis in both cell types"
In other words, winstrol has THE SAME effect as progesterone on progesterone receptor mediated DNA synthesis: they both block it. So rather than acting as an antiprogesterone in this study, winstrol, as well as nandrolone and oxymetholone, act in the same manner as progesterone.
I honestly don't know and can't find really reliable sources, but yes shbg is one of the reasons I recall.