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  • ERYTHROPOIETIN (EPO) for beginners

  • grAnabolic   •   Wed, Apr 25th, '12 10:22   •   35 replies, 14873 views

Erythropoietin (abbreviated EPO) is a relatively recent entry into the deceitful pursuit of glory. EPO is a protein hormone produced by the kidney. After being released into the blood stream it binds with receptors in the bone marrow, where it stimulates the production of red blood cells (erythrocytes). Medically, EPO is used to treat certain forms of anemia (e.g., due to chronic kidney failure). Logically, since EPO accelerates erythrocyte production it also increases oxygen carrying capacity. This fact did not long escape notice of the athletic community.

Blood doping is the process of artificially increasing the amount of red blood cells in the body in an attempt to improve athletic performance. In the past this was accomplished by transfusion. The athlete would “donate” a unit of blood into storage and then 3 weeks later, after the body had completely replaced the blood loss, transfuse the unit back into the body. This would occur just before a big race, effectively giving the athlete an “extra” unit of blood. This enables performance improvements in endurance sports because of the extra oxygen carrying capacity.

EPO has put a whole new spin on blood doping. No need for messy transfusions, just shoot up with EPO to increase your circulating erythrocyte mass. Until recently accurate testing has been difficult because the recombinant human EPO made in the lab is virtually identical to the naturally occurring form and there are no firmly established normal ranges for EPO in the body. Thus, over the past 10 – 15 years some athletes chose to cheat because, as long as they kept their hematocrit levels below 50%, there seemed little risk of getting caught.

EPO is an injectable protein hormone that acts on bone marrow to stimulate red blood cell production. This is a new drug which is being experimented with by some elite athletes especially distance runners and elite cyclists. It has been very effective for what it is designed for and sometimes is used as a replacement for blood transfusions. Athletes use this drug to dramatically increase red blood cells which are the oxygen carrying components of blood. Athletes are well aware that if they can increase the oxygen-storing ability of their blood they can increase performance. This is the theory behind blood doping. EPO does the same thing but is more convenient considering the use of EPO just requires a number of injections. Blood doping requires drawing out approximately a liter of blood, freezing it, then thawing it and reinfusing it several weeks later. EPO has a dramatic effect on hematocrit which is the percentage of red blood cells in blood. A hematocrit of 40 means that 40% of the volume of blood is composed of red blood cells which is about normal. Athletes not uncommonly have a higher-than-average hematocrit. When an athlete injects EPO, there hematocrit can rise as much as 40%. This results in an especially high concentration of RBCS. EPO use is most widespread amongst endurance athletes yet a number of weightlifters have been experimenting with it.

Effective Dose: Between 50-300 IU/kg of bodyweight. Not to be used for more than 6 weeks. Will start seeing effects on week 3th. Inject EPO daily for 2 weeks before competition day. After week 3th, your red blood cells will remain high for the next 3-6 months.

Comments

  • Ap801's picture
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  • Ap801
  • 3 years ago

Hey guys new in the world of steroids. Wondering if any one could help me find a reputable source of EPO. I have done some online research but nothing trust wordy. I would really appreciate it thanks.

  • Hillclimb89's picture
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  • Hillclimb89
  • 3 years ago
  • @Ap801

I've been searching everywhere for lyophilized epo. I hope that you found your source and can pass on any information you have.

  • 4x400's picture
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  • 4x400
  • 5 years ago

Firstly, if injecting EPO subq, then injecting every day is a complete waste of time and pins. EPO is proven to be equally effective at once a week injections (same weekly dose). Although I wouldn't suggest this until the dose is "dialled in" otherwise you risk of spiking your HCT level too high. Start out with E3D or E4D subq.

Intravenously the half-life is obviously way shorter, in which case ED or EOD is most effective.

****You may not see a performance boost until several weeks pass, but your HCT may well spike very high within one or two weeks. Checking HCT every few days as a minimum right from the start of a cycle is essential.***

Checking HCT first thing in the morning is important as this is when it will be highest. Better to use a home centrifuge than going to a lab.
The 6 week rule has no merit whatsoever unless you aren't using it in a safe way in the first place.

Aspirin is an important safety measure when dealing with high HCT. How high? 50%+ would be a conservative starting point. 75mg before bed. Perhaps 150mg if 55%+.

Not recommend to go above 55% due to increase clotting risk and you are not likely to get any extra boost in aerobic capacity due to blood being too viscous.

150IU/kg/WEEK is PLENTY as a starting point. Much less has been known to cause MASSIVE increases in HCT.

  • sprints's picture
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Wondering if anyone can help on a where to get EPO online. I've searched and had some BS sent. Given what EPO can do I'd want to make sure its the right stuff. Need to try again. Send a PM

  • hgh_and_aas's picture
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Just sent you a PM request. I have a source for legit EPO. But if you're not into endurance sports why mess with it? Its one of the more dangerous drugs in the BBer's arsenal and you can get the same increase in RBC volume with EQ and/or anadrol. Anadrol was the choice drug for anemia and that's what its approved to treat. EPO kind of made anadrol superfluous.

  • adventureswithrage's picture
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could you pm me with the source?

  • crlsbrbs's picture
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Hi there could you tell me where your epo source is from, country? I am from europe
regards

  • hgh_and_aas's picture
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He's in China. PM for details. I don't make shit from him I just hate to see people get burned.

  • Jay-Dawg's picture
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Thanks for the great information! Do you have any suggestions on what type of centrifuge to use? I see that they vary tremendously in price. Also, how much blood is needed to run a test? Do I just prick my finger, or do I need to draw blood?

  • sprints's picture
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Hello there wondering if anyone can talk about there experience on EPO, in terms of the percentage output benefit.

  • Jay-Dawg's picture
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I'm still in the process of researching. From what I have read you can get a 5-10% bump in performance.

  • betheman's picture
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  • betheman
  • 7 years ago

I'm at 52 hemocrit just from test.

Would the extra 1-2% make a significant difference in your performance?

I do some triathlons and cycling, don't feel any stronger than before :-)

  • cristophe's picture
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  • cristophe
  • 7 years ago

Hi,
I'm a professional athlete and some months ago i started using EPO and GH.
I'm doing everything by myself without any guide.
I'm looking for a doctor or someone who can help me because I want that a doctor write to me the posology of epo and gh according to my training schedule and my competitions.
i'm taking eprex 4000ui per week and GH 0,5mg per day but i don't know if i have to pause or if i can take them for the whole year pausing only some days before antidoping test.
thank you!

  • subing2miler's picture
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  • subing2miler
  • 8 years ago

The thing I think that sucks is that most EPO through the sources on this site seem very sketchy. Its just seems way to cheap to actually be legit.

My EPO comes in 1 vial at 4,000iu in liquid form and costs $38 per vial. I see a lot here for like $10 and that doesn't seem right. The same generic I use has cost me at least $25 in mexico per vial. To see it here for $10 is weird. EPO that comes in a powder form also makes me feel skeptical of the product. Almost all brands of EPO i've used come in liquid form (which is sustainable at room temperature for many months).

The great thing about EPO is you can test its legitimacy by taking a simple CBC. If after you taken about 24,000iu's and waited 11 days, if you hermatrocrite hasn't moved more than 1% then its probably no good.

  • subing2miler's picture
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  • subing2miler
  • 8 years ago

Cleyon, you're full of crap! If you're healthy and have levels below 55% then you should never have a problem with taking EPO. Now if you take 1 vial everyday for 6 weeks, that might be bad unless you're taking 1,000iu then I wouldn't worry. "It really depends" is pretty much the general rule. EPO use does not lead to cardiac arrhythmia unless you're abusing it or exceeding the safe hermatrocrite level of 55% (one could actually go as high as 60%).

I've taken it for 6 years at 4 vials (4,000iu each) every month. No problems, good blood pressure, 56% hermatrocrite, and heart rate as normal as ever.

  • fastguyxxx's picture
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i sent you a friend request. i just have a couple questions

  • sss's picture
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hey subing2miler- could you accept my friend request, I have some questions

  • Cleyon's picture
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Excuse me, but how am I full of crap? I'm giving the information that has been passed on to me by some very successful people who I know personally. Did I claim to be an expert? no, but did I really say anything that was completely wrong?

  • subing2miler's picture
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Yes this was completely wrong that "The one thing that seems to be consistent is not to exceed the six weeks of use. Doing so can lead to cardiac arrhythmia and other circulation issues."

You never stated under what conditions. I've been and many others have used EPO consistently for years and never had such a issue.

  • Cleyon's picture
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Sub, I appreciate the knowledge you seem to have, my issue was the way you started off the conversation. Maybe you should have said something like, "Cleyon, it's not how long you take it, but the amount of EPO being used."

Let's just reset, and say that I apologize for being incorrect.

  • subing2miler's picture
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Those who passed the information on to you were very inaccurate. EPO can be taken for as long as you feel you need it. As long as you monitor your hermatrocrite and hemoglobin levels and never exceed 55% then there should be nothing to worry about for most people. Now there are those rare cases that someone might have an existing condition that is exacerbated by EPO but in healthy individuals like myself who don't have any pre-existing conditions, there should never be a problem (unless you don't monitor your blood levels every month).

EPO works pretty simple, it takes 12,000iu's to increase your hermatrocrite 1% (the epo i use comes in 4,000iu per vial). If someone took one vial at 4,000iu then it would take 10 to 11 days before you actually start to feel that one vial (that's a fact). If you don't feel it by that time then most likely your stuff is no good.

An increase in ones hermatrocrite by use of EPO only lasts for as long as your activity level and eating habits allow. If you run 70 miles a week and eat a high carbohyrdrate diet then it will fall faster. But if your pretty sedentary and eat foods very low on the glycemic index, then it will fall slower. Based on this you see why monitoring your hermatrocrite and hemoglobin is critical so you know how many units you need to take each month to sustain a consistent level. Never go over 55%.

EPO is safe, but when abused (55% level or higher) then there will be negative effects. But at safe levels (55% and below), in a healthy individual there are no problems. The info from your friend is to general and wrong for most people.

  • Cleyon's picture
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  • Cleyon
  • 8 years ago

EPO is a very productive drug, but needs to be used with caution. I have several friends who are endurance athletes that have used EPO to varying degrees of success. The one thing that seems to be consistent is not to exceed the six weeks of use. Doing so can lead to cardiac arrhythmia and other circulation issues. That being said it's much safer than blood doping.

Thanks for the writeup grAnabolic!

  • hgh_and_aas's picture
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EPO was Lance Armstrong's drug of choice for his 7 Tour de France wins. Have any of you guys seen the new documentary about Lance on HBO? Its crazy what this guy was taking and making the other guys on his team use. EPO, testosterone, cortisone, hGH, anabolics. And the guy was skinny as fuck. He was also doing blood doping by having his guys give about 2 pints of blood 3 weeks before a race and they having it re-injected into their bodies via transfusion right before a big climb. Crazy!

  • subing2miler's picture
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  • subing2miler
  • 8 years ago

The fact that at the end of this post the guys says it will "stay high for the next 3-6 months" is total bullshit! I've taken epo for the last 6 years and depending on your diet and exercise regimen your hermatrocrite levels will only stay that high if you sat in a chair all day. EPO is therapeutic and has to be taken on a regular basis depending on ones blood tests. For me I had to take 6 4000iu every month because of the level of my activity. I didn't once didn't take it for a month and my levels dropped back to normal. I take pharmaceutical epo too, not the cheap crap (but really there isn't such a thing as cheap epo), but in other words I take name brand.

  • depfife's picture
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I agree with you, 2miler.. Could be 3 months, probably only 2.. This is why I only doped one month prior to a major competition..

  • DainNev2010's picture
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Thanks for the Info, all the bunk you read about killer side
Effects put me off, I'm keen to give it a go.
Do you have a good Suppliers who ship?
Sent you a friend request, if you can help I would be grateful.

  • ScienceGuy's picture
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You don't want to mess with EPO unless you know exactly what you are doing and are getting blood tests at least every two weeks. The info posted above here is full of garbage. take it for six weeks but results for six months? Seriously? If you take it for just six weeks and then stop, your blood levels will be back to normal within a month.

  • ShiniAuspicious's picture
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Hey bro, I really need another source for EPO. Mine disappeared!

  • Epoguy's picture
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  • Epoguy
  • 8 years ago

Some really, really useful info on EPO here regarding how to inject, doping regime etc: http://anemiapatientgroup.blogspot.co.uk/2009/05/blog-post.html

Note that the guy who used to supply it, no longer does so.

  • jasonh's picture
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  • jasonh
  • 8 years ago

Thanks been seeing this stuff floating around sites and was wanting some info on it,know i have some