Armwrestlingfiend's picture
Armwrestlingfiend
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+ 1 Estrogen Rebound

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Hi all I was reading through the forums yesterday and had an interesting read about ai’s and estrogen blockers and I had a few questions. For those of you on TRT taking adex how do you control or eliminate having the estrogen rebound associated with adex. Because as I read after stopping adex all the estro that was bound to it becomes freely available to the body again. So it seems like you would have to stay on adex continuously while on TRT but that seems dangerous. And if you taper off is there no estro rebound? Last question is what is the protocol when blasting and then going back to cruise on your TRT dose? Just a higher dose while blasting and then a much lower dose while cruising and then taper off? Wouldn’t Amasin be a much better choice for doing this to avoid all of the estro rebound and the negative sides from adex? Anyway I was just very curious and would like to know more. Most of the forums tell the difference on the two but don’t really say how to control the rebound from adex. Thanks in advance for any and all comments.

giardap's picture

If using HCG as a part of a pct (of sorts) or a restart or for fertility etc., you can pretty much guarantee an estro rebound. So timing is the key to getting around that.

Armwrestlingfiend's picture

Ah so you mostly get rebound while using hcg then? Thanks for the info my friend I appreciate the reply.

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giardap's picture

Moreso that its an unaccounted for source of estro, if that makes sense. People think hcg just makes test but it also makes several estrogens too. Lots of people dont time their pct properly too, and will begin while they are still on cycle (more or less). Lots of people also wandering around with elevated prolactin, wondering where it all came from or blaming nor's, when really they drove estro up which drives prolactin up and then they smash estro, think life is great but just end up with wacky ratios of 1 hormone to another and a limp noodle or no libido.

It's all about timing (and bloods where possible) and balance from the get go, really

Armwrestlingfiend's picture

I did not know that it made estrogen too but my doc did say to take adex when I start hcg so that makes sense. And limp noodle sounds fucken scary I’ll be testing for prolactin on my next bloods. I’ll be doing more research on timing now too. Makwa shared his experience down below on how he times it too so that was helpful but I know we all react differently so I just gotta do more bloods and more research to find my balance. Thanks a bunch man I really appreciate it. I realize how smart we need to be going about this stuff and it also seems some docs aren’t informed as much as they should be in my experience.

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giardap's picture

we all react differently

So true!

Yeah there is a massive gap in knowledge for men's health. It's crap, but we can take ownership, which is good! Knowledge is power!

Armwrestlingfiend's picture

That’s right brother we gotta arm ourselves with knowledge it’s our responsibility.

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Makwa's picture

Never had any rebound when stopping Adex.

JARHEAD2's picture

Are you TRT brother? If so, what is the protocol for an AI when going from cycle back to TRT? I know a lot say they don’t use an AI on TRT, but I also know it’s necessary for many.

Makwa's picture

I don't need an AI with my trt. I typically use adex on cycle when I need an ai since asin doesn't seem to work to well for me for some reason. When the cycle comes to an end I just drop my ai (adex) 1 wk after my last shot and resume my normal trt dose. Since test is now stopped estro levels should fall correspondingly so there shouldn't be a need for any further ai. Running the ai for a week after last shot is plenty to prevent any rebound effects from happening since by the time the ai clears your test levels should have dropped significantly so conversion really shouldn't be an issue any more. I think this potential rebound from adex is way overhyped.

Armwrestlingfiend's picture

This is a huge help and awesome info thanks makwa!!

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JARHEAD2's picture

Thank you brother!

AF, there’s your answer bro from someone with experience!!

Muffins's picture

Estrogen rebound is most evident with letrozole use. Shouldn’t be as much as an issue with anastrozole. To avoid rebound, you switch to aromasin or taper and jump on nolvadex for a few weeks, preferably one week overlapping the AI.

Armwrestlingfiend's picture

Thanks Pez I’m glad I know now thanks for the awesome info bro! I was really confused at first.

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Bill G's picture

What is causing the estro rebound? Adex , being an inhibitor of the enzime that converts test into estrogen. So if the enzime is stoped the conversion is stopped. I dont believe while you are taking the adex it is storing away ever incressing amounts of estrogen. To be released on you like a pack of ravenous milk slinging wolves. What happens is when you stop taking copious amounts of test your body frieks out and tries to restore balance. This is where the novadex comes in. It basically covers the estrogen receptors. Acting like estrogen but not having the effects of estrogen.
If hrt therapy is to restore ones test levels to say what they were when we were 18 or 22 and not over why is adex needed or any ai for that matter. I didnt have to take one when i was that age.

Armwrestlingfiend's picture

That does make sense Bill. I was just wondering about estro rebound because In another forum there were links about adex and they said that after you stop taking the adex that all the estro is then free to circulate again. What you said does make sense though if you stop the enzyme converting it then it is stopped. I just read conflicting ideas on here I guess that’s why I’m confused. And I guess you wouldn’t need ai for hrt but I read a lot of people getting prescribed adex for TRT so I was wondering if they experience the rebound and if so how they go about dealing with it. I guess I have some more research to do. Did you see the post yesterday about the ai and estro blocker? Jarhead posted some links and that’s where I read about rebound from adex. Like I said what you just said makes total sense if you stop the conversion then it’s stopped so I guess I’m back at square one and confused as ever haha.

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Bill G's picture

Jarhead always has the info. I love reading his comments. No homo.
And yeah if there is one thing ive learned is i really dont know very much.
I know guys on hrt and they take the adex continually. So in that case there should not be any concern about the rebound. Hrt for life. Or at least till your done living it.

Armwrestlingfiend's picture

Ah that’s what I was wondering too! If they just stayed on adex indefinitely. I guess that’s ok if they keep an eye on their hdl and ldl. Ok thanks for info Bill I shall continue with more research we have to be freaking scientists here!

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Hustle28's picture

Well you can switch to aromasin at any time just have to adjust ur dosage as ur taking it.

For instance I run adex while on cycle but when I pct I use aromasin along with nolvadex and clomid just to avoid the rebound and it works quite well. It’s just ur personal preference one is more expensive and kinda weird to adjust which is aromasin and adex is slightly cheaper very easy to adjust imo

Armwrestlingfiend's picture

Thanks for the info hustle. So pretty much to avoid rebound you would just switch to Aromasin during your cruise or pct in this case? And it looks like adex is easier to adjust so that’s what most would prefer during cycle? Thanks again hustle much appreciated!

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Hustle28's picture

yes Exactly but since you have all this estro backed up you have to adjust ur aromasin daily till you stabilize. So maybe split dosages am pm and maybe slightly higher so that you can avoid the estro rebound. Also a great thing while off cycle or trt once you switch it will help raise ur igf levels slightly.

And yes my personal preference I use adex as its very easy to dial in and also very strong while on cycle to help with those estro signs. Always make sure to take a blood test pre, during, and post cycle

Armwrestlingfiend's picture

Thanks hustle! I was reading all the great benefits from Aromasin like you mentioned it increases igf and I read it also decreases sex hormon binding globulin giving you way more bang for your buck that’s why I was wondering why most don’t just use Aromasin. But you explained it well! Pretty much just easier to dial in and then switch to Aromasin while cruising or pct. sorry bro one last question is adex and Aromasin pretty much the only thing you need to blast and cruise if you were just blasting a high dose of test?

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Hustle28's picture

Well yes obviously the more test you use the more e2 sides you will be having to deal with. If ur not on trt I would suggest you not blast and cruise. You want to avoid trt for as long as possible. Anyways lots of info just keep researching and you will find almost all of the answers to ur questions

But if u run into something post it here lots of great members here to help dissect issues and square you away

Armwrestlingfiend's picture

Ok thanks hustle sorry for all the questions and thanks again for all the info brotha!!

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