Steezy's picture
Steezy
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+ 1 Bloodwork on trt / Nolvadex on blood work.

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Question for you guys on trt, and yes I’ve used the search bar and been trying to research this for the last couple days. Will taking Nolvadex have any affect on blood work when the labs are testing for Test, free test, Estradiol, CBC.
Been taking trt 100mg for 8 months now and I’m convinced I’ve had higher than normal estrogen. In the meantime before my apt I’ve been taking Nolvadex within the last month half/ two months. In fear of Gyno.
I have to get bloods this week or next and I’m wondering if I made a mistake and didn’t stop the Nolvadex long enough ago before my bloods.
Thanks guys. Kinda crappy decision I made on my part but was in serious fear of Gyno seeing how I’ve already had surgery once before to rid myself of it.

Dacky's picture

So what dis your bloodwork show in the end?

MedDx's picture

OP could benefit from a CMP, too, since it wasn't noted.

MedDx's picture

No offense...it's all good bro..

So much that FSH/LH are responsible for in the body....hpta gets shut down...then body systems gets thrown out of range...

giardap's picture

A lipid profile is not going to tell and nobody suggested if it was. The person who suggested it is a medical pro and did so for health reasons, given the OP's (likely) needless self medication.

Despite completely missing the point you answered your own question:

A lipid profile is very important because many steroids and ancillaries can have a negative impact on them

This Over 40's/TRT forum, specifically, is about men's health. Everyday, we see people come on the site with questions about their crazy notions, and it is the members like those below, who actually give a damn about the type of information that gets dished out here, who will take context into account and discuss the bigger and more important picture.

Hope that makes sense.

giardap's picture

I know you weren't big man, but misplaced as a criticism that's all. And I do know that you give a damn too. I've seen you sharing your knowledge and you did it here too.

I've seen how you operate in the forum trenches, and I respect it. +s from me

MedDx's picture

Thank you, bro! Smile

giardap's picture

Ultimate respect for you man. Big time.

MedDx's picture

To you as well.. Smile

DeathDefier's picture

What specifically is your cycle?

MedDx's picture

Ask doc for a lipid profile. I don't think your decision was bad, but if you had legitimate reason for trt, then you could have legitimate reason for gynecomastia.

giardap's picture

Ah go easy boys, nolv is a SERM not an ai
It shouldn't affect the TRT regime but there is a very very small possibility that test might be a tinchy tiny little bit elevated if any lh was produced...fractional. But that is very unlikely as the negative feedback loop is so strong in terms of control. (there are two hops in the neg feedback loop before test is made)

Get the bloods and only they should judge whether you need to mess with nolv. Unlikely at 100mg unless you have other issues.

Dacky's picture

^^^^^^ This

It’s not even going to register on the blood test in terms of hormones. MedDx suggested a lipid test and I second that.

OP.....I see below your estrodial came in at 39 on your last test. And then what exactly caused you to worry that you had high estrodial? Is it because you saw a borderline high number and then became anxious about it or did you genuinely have symptoms. I’m interested in your answers and not because I’m going to bash you but because there may be a valuable learning experience here.

MedDx's picture

X2....valuable learning experience

Makwa's picture

Would nolva influence LH/FSH?

Dacky's picture

It does say in normal males, so I guess this may or may not be true in men who use juice.

That’s the key. Add some test in there and you’re shutting down that HTPA in the most powerful way it’s possible to and no amount of nolva is really going TK have much it any measurable effect.

As an aside HCG is the exception here. While it does nothing to stimulate LH it does mimic it and thats why even on cycle it will somewhat raise testosterone and estrodial. Good news if you’re trying to maintain fertility or maximise the chances of an effective and successful PCT.

Dacky's picture

Like Giardap said a theoretical possibility. However the negative feedback loop is so strong that even if it did this is unlikely to be significant such that the doc would worry or even register it. If I were a betting man I’d say it doesn’t even make LH/FSH move.

Ozninjaguy's picture

You might lose that bet. Tamoxifen has a significant effect on LH, FSH and Test, which is why it is a foundation drug for any effective PCT. https://www.ncbi.nlm.nih.gov/pubmed/6193975

Dacky's picture

How much are you willing to lay down on this one? I’m happy to go big ;-)

giardap's picture

See that study is on those not on cycle, so while you are bang on/dead right for eugonadal people or those about to enter PCT (when test is lowered right down or at zero), this doesnt apply on cycle.
Cycles have a constant/uninterrupted supply of test

A constant supply of test causes a constant activation of the negative feedback loop but by more than 1 hormone

Administration of exogenous estradiol or testosterone in men with hypogonadotropic hypogonadism receiving pulsatile GnRH therapy decreased gonadotropin concentrations, demonstrating inhibitory effects of sex-steroids at the level of the pituitary
https://www.ncbi.nlm.nih.gov/books/NBK279070

The reason that AAS trump the stimulating of gnrh is because gnrh, even when stimulated by blocking estrogen with clomid (stronger at the hyp than nolv) or nolv, is because gnrh is released by a sort of weak pulse.
SERMS only work on estrogen, miss testosterone and activate what is ultimately a pretty weak secretion process.
However, on cycle, they cannot beat test which works at both the hyp and also the pit as a part of the neg feedback loop.

It is all about the neg feedback loop; strong versus weak, constant supply versus little pulses, 2 against one.

Ozninjaguy's picture

Point taken. (@ Dacky) I assumed that because the OP was on TRT and was probably in normal range that the Tamoxifen would have the effect as stated in the article - but the TRT dose is exogenous Test which changes everyhing - thanks for the correction.

Dacky's picture

No worries mate. Weirder things have happened. I once managed to double my total test and estrodial numbers running just 250iu of HCG alongside my trt dose of test. It will raise it but we were all surprised by just how much in my case.

giardap's picture

natural test cycle on circadium rhythm boys, very different to trt constant supply or supra cycle

really interesting back and forth there, great seeing things like this discussed

Ozninjaguy's picture

really interesting back and forth there, great seeing things like this discussed

Yep. I learnt something today - makes it a good day.

Dacky's picture

Thanks bro. Yes I agree and what I always say the true beauty and value of this site really is. Oh yes and of course a great place to source and review of course.

Reply PM send by the way mate for when you can. I hope it may help a bit.

giardap's picture

Cheers buddy, I see that now, gonna read...

johnmarshall12's picture

Nolva will not lower serum E2. It merely blocks it from the Estrogen receptors. Only AI's will lower E2 levels.

Steezy's picture

I’m very well aware of my mistake. That’s why I was asking if Nolvadex would affect my blood test. Because if it would i would figure something out with my doctor. So I take it no one has any experience with trt bloods and Nolvadex together? lol

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Greg's picture

You want your doc to make decisions based on good data. Yes you made a mistake taking ANYTHING that would change the results of your bloodwork. You should have just mentioned your fears to your doc and let him decide if he should test early or perscribe an AI.

You're full of shit.

Steezy's picture

I’m just trying to figure out if me taking the Nolvadex would have any affect at all on my labs for test, free test, estro, cbc bloods. Was worried about it having an affect on my bloods and not giving an accurate number on everything.

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Porkbythapound's picture

Not too sure about the nolvadex but if your on trt doeses / 100mg wk that your stating you should not have to worry about gyno. A minimal dose of Arimidex should keep your estro down. I’m assuming you’ve had prior bloodwork. What was your estrogen without ai / and or with an ai? These are the basics we have to figure out before we start tweeting things. Good luck

Steezy's picture

Estro cane in at 39 at my last blood work after a few months on 100mg with no ai.

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IrishMack's picture

Question for you on trt, its kind of obvious you are self medicating so why not go and see a doctor?

Steezy's picture

Why would I lie on the internet about something so dumb.
I do see a doctor, this blood test is for him to determine if he wants me to have an ai or not. Last blood test was just my first round of bloodwork to see where I was at.

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Greg's picture

Why take an AI before taking the blood test to determine if you need an AI?

That's like taking an aspirin before checking to see if you have a fever to see if you need aspirin.

Steezy's picture

I never said I took an Ai before my blood work test to see if I need an ai. I said I look Nolvadex for about a month and half/ two months.
I was just wondering if the Nolvadex would affect my test, free test, or estrogen on bloods.

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KMC's picture

Why would I lie on the internet about something so dumb.

What is a co-signer.

I'll take state capitols for $600, Alex.

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