Pramipex.. What the heck is it anyways?

Pramipexole is a dopamine agonist of the non-ergoline class. Dopamine agonists act directly on dopamine receptors as if they were actually dopamine. It binds mostly to the receptors of the D2 Subfamily especially D3. It has been used recently to help with problems in sexual disorders caused by antidepressants. Today we are going to go into the effects or advantages it has for the bodybuilder today.

• Pros & Cons

  • The pros of Pramipexole
    1) The main benefit is reduction in prolactin levels
    2) growth hormone levels increase
    3) Increased Sexual sensation
    4) Decreased refractory period (Time between orgasms)
    5) Better sense of well being due to altered dopamine levels

  • Common side effects
    1) Nausea - This is very common at the beginning because of the altered dopamine levels
    2) Sleepy - Depends on the person and dosage but ive almost fallen asleep at the wheel
    3) Numb hands from high human growth serum levels produced by the drug
    4) A bit scary but disorientation has occurred like my mind is foggy
    5) When taken at night it can actually keep you up as well

• The proof is in the pudding

  • In 1992 Schilling investigated pramipexole in a randomized, double-blind, crossover study in 12 healthy volunteers.These test looked at pramipexoles effects on prolactin, human growth hormone, thyrotropin, cortisol, and corticotropin levels. Single oral doses of 0.1, 0.2, and 0.3 mg pramipexole and placebo were studied over a period of 24 hours. Pramipexole decreased serum prolactin levels in a dose-dependent manner, with a maximum effect after 2 to 4 hours. Serum levels of human growth hormone were dose-dependently increased; however, this effect was only significant 2 hours after drug administration. Furthermore, a slight increase in serum cortisol levels and a slight decrease in serum thyrotropin levels was observed.

• The Science of pramipexole

  • Prami increases your GH production, by stopping the release of somatostatin. Basically somatostatin is secreted by your hypothalmus in response to growth hormone being released, the somatostatin closes the faucet so to speak on the gh dripping into your body, This would be known as a negative feedback loop. Using prami right before your about to sleep will let you produce several times greater Growth hormone over night while your fast asleep and your insulin levels are low.

• Dosing

  • 0.1 mg of an oral dose of prami effects both prolactin and GH production. With a 0.5mg dose prolactin levels decreased by about 50% and GH increased by 400%.

  • Many people get nausea when using pramipexole I know that I personally do. To combat this take it at night a few hours before bed if possible. Start with 0.1mg when ready then ramp up to 0.25 and so on up to 1.00 gram eventually however 1.00 gram will take at least a week to work up to.

• Conclusion
  Prami would be a great addition to someone using peptides such as GHRP-2 or 6 and CJC-1295, They would work synergistic-ally with most peptide cycles and even better when adding aas into the mix.

References

1. Schilling JC1, Adamus WS, Palluk R (1992) Neuroendocrine and side effect profile of pramipexole, a new dopamine receptor agonist, in humans. Neuroendocrine and side effect profile o... [Clin Pharmacol Ther. 1992] - PubMed - NCBI
2. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2203276/

Any feedback on this or questions are appreciated in this forum post.