posted Sat, 02/16/2019 - 18:10
2824
+ 5 Always research your meds
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I've been taking paroxetine for a while now for anxiety and decided to Google some more about it
The paroxetine finding helps explain previous studies showing that it reduces tamoxifen therapy’s effectiveness,” Chen said. “And it has implications for patients with estrogen-sensitive breast cancer who are on other medications.”
In a second round of tests, the researchers not only confirmed AroER tri-screen’s effectiveness on a larger scale, they also found that antifungal medications oxiconazol (Oxistat) and bifonazole (Canespor) exhibited aromatase-inhibiting properties, while the antidepressant paroxetine (Paxil) acted as an estrogen promoter.
Link
https://www.cityofhope.org/blog/antidepressant-paxil-estrogen
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Most psych meds will especially anti depressants that are serotonin related.
Tamox being a pro drug/ precursor it has to metabolise in your system to function.
For it to function, when it enters our system a group of paticular protein cells bind with it activating it and transporting it to targeted areas such as breast tissue.
These protein cells are the same ones used by antidepressants etc for the same reasons, obviously the interraction is that the cells are already being used therefore the nolva cant bind to them to metabolise or activate at its standard level.
The drug you mentioned is definatly one of the ones that will prevent nolva from functioning at its full potential.
I was surprised when I read that about the nolva
Here we go: https://www.webmd.com/interaction-checker/default.htm
This works, a great interactions checker
Solid link
Tamoxifen reduces letrozole blood levels by 48%
important for anyone considering alternative pct's or who is looking to keep gyno at bay but finds they cannot stop the estro symptoms on cycle
Great topic +'s
*38%
That is incorrect.
They actually compliment each other.
One being a potent anti estrogen that is capable of decreasing estrogen anywhere in our bodies.
One being a serm that targets and occupies receptors.
Both seek to destroy tumors.
The only study that showed any interraction was one in woman who were terminal, that interraction was after 11 months of everyday administration.
Letro was @ 2.5mg and nolva was @ 20mg.
Nolva was ran for 6 weeks stand alone for the first 6 weeks.
Besides a few different cell signalling pathways decreasing there were no negative interractions, the only side effects reported were hot flushes and most of them ended up surviving, one died.
After adding the letro estrogen decreased by a further 86percent and tumors were non existant.
Nolva and letro together is a great combination.
When i posted the old gyno lump protocol that was letro first followed by nolva after an overlap, there is specific reasons for that overlap in regards to any possible interractions or side effects.
Basically the timing is crucial.
Up regulation overlap time for down regulation followed by tamox occupying receptors targeting specific sites, when there is any kind of rebound we are safe due to nolva and it gives time for cell replenishment and refreshment.
In that process letro has cleared estro from any part of the body it may have been and also had a very decent go at shrinking if not killing the tumor/ lumps.
Nolva steps in and finishes of the job whilst also keeping estrogen receptors blocked from any near future mishaps whilst our body fights for homeostasis.
It is the users responsibility to counteract any other issues they may have as an individual.
That could include dry joints for example, fish oils, krill oils etc can be added.
Remember the other key to this approach is to be off all steroids and all esters have cleared.
The only condradiction that doesnt even matter to this protocol is that nolva can be interperated by men as a form of estrogen in the initial metabolising process for up to 7 days.
Nope,
You are wrong. Very wrong.
https://www.webmd.com/interaction-checker/default.htm
Use this and check for drug interactions between the two
https://www.fertstert.org/article/S0015-0282(14)02553-9/fulltext#sec2.1
38% drops in serum levels
Facts, not fiction.
It also makes you not get off. Rub that fucker all day no go.
Aspirine leaflet: increase headache, lol.
But I know what you mean, thats why I always read the leaflet especially when I get a medication for my daughter from the doc.
My daughter has vitiligo and I always research the shit out of what they give her
"YES" always research your meds. Besides side effects; you may find that it is going to interact with other things you are taking which can pose huge problems. +
Exactly grapefruit juice can mess up meds even
Yup. Crazy.
https://www.webmd.com/hypertension-high-blood-pressure/guide/grapefruit-...
Alphamale500Researching the meds you're going to take is always a smart idea and necessary. That also goes with supplements of any kind. Even though a lot of people don't really see them as medications, they should be treated the same way. Many of them have interactions that could be very dangerous.
I suffer from bad anxiety myself, and I used to take paroxetine(Paxil) also. If you're looking to switch medications now since you found this out, sertraline(Zoloft) is a very effective medication that I currently use without noticing any estrogen sides, but it's still a SSRI. It's used to treat depression, panic disorder, anxiety disorders, OCD, PTSD, etc. Basically, the same symptoms that paroxetine treats.
However, all SSRI's(which paroxetine and sertraline are) have been found to affect estrogen in multiple ways.There's studies that show estrogenic and antiestrogenic of SSRI's. So it really depends on the person.
If you really suffer bad from anxiety you may just have to continue to use your medication and deal with any side effects the best you can. Or if you're dead set on no longer using any SSRI's, maybe you can try bupropion(Wellbutrin) which is in a different class of antidepressants and not a SSRI.
Ill ask my doc about that next visit I've had it since I was a child I have Xanax for panic attacks as well but I never take them unless it's a super bad attack
I’m prescribed Pregabalin 300mg per day for anxiety and works better than anything I’ve ever tried. I have zero and I mean zero side effects from it. I refuse to take an antidepressant for anxiety - long and short term side effects and crazy withdrawals if you ever want or need to come off....no thanks.
Alphamale500I hear what you're saying about refusing to take an antidepressant for anxiety, because of withdrawal and whatnot. They can be really a bitch to come off.
But for many people, anxiety is really just a symptom of depression. And a lot of people who have anxiety also suffer from depression. Many antidepressants act on the same neurotransmitters that are involved with anxiety and depression, so they help in both situations. So, many people who have anxiety issues can really benefit from taking an antidepressant.
Yes completely agree but in my case its 100% not related.
Alphamale500In that case, using an antidepressant could possibly do more bad than good for you. Have you ever tried Buspar that I recommended to 333? It's really a great medication with no sides for most.
I'll search that one up
Alphamale500I have Klonopin for really bad attacks. I DO NOT RECOMMEND THIS, but I also use them for the bad anxiety that I get from tren. Xanax do work much better but they're just too addicting for me, and it's impossible for me to take them as prescribed. I have a really addictive personality.
Best of luck bro, and I hope everything's works out for you! I know how you feel.
Sorry mate - But I strongly disagree with running anxiety medication to be able to run trenbolone.
Alphamale500That's true. But I have very bad anxiety and I need to take my anxiety meds on a regular basis anyway. What I really meant was that the anxiety meds that I take make the tren sides a lot more bearable. I don't take them just so I can run the tren. My fault, I explained that the wrong way.
So you see nothing wrong with running steroids (especially harder ones) when your anxiety is that bad that you need medication for it?
Alphamale500Like I said, I need to take medication to treat my anxiety disorder with steroids or without steroids. No more medication needed when on cycle, than when off. So no, I don't think there's anything wrong with me choosing to use steroids just because I have anxiety that I take medication for! It's my life, my decision, and my choice.
Do you have any anxiety issues?
Is your doctor aware you are running this medication with steroids?
Alphamale500Well, he's aware that I take the medication with trt. Why, where are you going with that? You gonna tell him! Lol..
Alphamale500And believe it or not, recently while I've been on cycle I've been able to reduce my daily Klonopin dose by 1mg. I actually feel better and have overall less anxiety when on cycle. I think it's from the physique enhancement and the overall well being feeling from the gear. Whatever's the cause, I really feel great when juicing.
Sometimes you need to take the time to reflect and see that Tren isn’t worth it bro.
Alphamale500You're right, tren does have some side effects that can be hard to deal with. But it's awesome muscle building and other effects make it worth it for me.
You're a tren guy, aren't you? Like last month I read a post that you wrote about tren, and I tried to send you a fr request to talk to you about it but got no response.
I used to be, 2018 I had a bad run and I won’t run it again for a long time if ever.
No disrespect bro, I’ve sent you one. I didn’t check my f/r’s
The Xanax makes me just straight up pass out and I heard of its addictive side so I stay way clear unless completely need best of luck to you as well bro
Alphamale500I also take Buspirone(Buspar)which is another medication used to treat anxiety, and is not addictive in any way and has been completely side effect free. Buspar starts working the day you take it and doesn't have to build up in your system.
It can help with depression as well. If I could recommend just 1 medication that has the least amount of sides and really helps with anxiety and depression, it would definitely be Buspar. You should really look into this medicine.
I have that in my cabinet right now that's what my dad takes and works Great for him I ran it for a week and was not good for me at all
Alphamale500Were you getting any bad side effects that made you stop taking it? Like I said above, it usually starts working right away. But for some people, it can take 4-6 wks or so to really start working.
Unless you were getting some bad sides, maybe it would be worth it to take it for a while to see if it can help you. I know when you first start taking it, it does give you that weird kind of tingling feeling but that goes away.
But only you know what works best for your body. I've been taking different anxiety meds for about 12 yrs now, and I really know what a bitch dealing with it can be. So if you ever need any advice or anything just ask! I'm gonna send you a fr request.
Accepted
Alphamale500Oh yeah, it really can mess with your dick as well!
RustyhookerAmazing whats found when you research. You can find many of the chems we use that act negatively with medicines and over the counter drugs
For sure I was surprised
Paroxetine...my girlfriends worst nightmare. If you know you know.
I don't know lol unless it's related to snoring I snore like a pig on the stuff
Great for stoping premature ejaculation. One of those an hour before sex, makes it impossible for me to cum.
So you are recommending people to take this as a remedy for premature ejaculation. Simply brilliant. Why didn't I think of that. Oh because I'm not a knuckle fuck like you -2
Oh ok I guess we are now gonna recommend people take antidepressants for what they are not prescribed for. Great job guys. I understand Mr bully being upset and negging me but a couple others that don't have the balls to tell me why they negged it. I'm done here folks neg away
I personally didn't neg you but i think your read his reply wrong is the reason you might have got negged. Your reply sounds like your name calling him for a wrong reason bro
The problem here is I've taken paxil for an antidepressant. It fucked with me worse than any other one I've been on. So to throw it out there as what he did was reckless. I've been called way worse than knuckle fuck on here. I negged him called him on it and have moved on. Just to come back here to find that a couple chicken shits voiced their opinion with out saying why. Oh well
Don’t remember recommending them. Don’t know what your problem is but take a chill pill.
Alphamale500Yeah that's the thing though. It doesn't just help with pre-mature ejaculation, It really does make it impossible to cum. And then sometimes you can't even get your dick hard! Happened to me anyway.
Oh shit really I didn't know that. I've been having to nail the wife like a jackhammer just to get off I bet that's what it is it's like tren dick almost
No homo