Aromasin (Exemestane) Increases Natural Testosterone Production
(Re-written version in my own words per Mod and included a free-to-view link of the publication)
The Journal of Clinical Endocrinology & Metabolism published a paper titled "Pharmacokinetics and Dose Finding of a Potent Aromatase Inhibitor, Aromasin (Exemestane), in Young Males" on July 02, 2013. In this study, increases in natural testosterone were recorded in 12 healthy males ages 14-26 over a 10 day period. Both 25mg ED and 50mg ED dosages were tested.
Here are the notable findings taken directly from the study:
"There was an increase in circulating testosterone concentrations after both 25 mg (60 ± 58%; P = 0.001) and 50 mg (56 ± 48%; P = 0.003) exemestane. Androstenedione concentrations were increased as well after 25 mg (32 ± 36%; P = 0.004) and 50 mg (47 ± 59%; P = 0.052) exemestane, respectively (Fig. 1 and Table 2). SHBG concentrations were decreased by 21 ± 7% (P = 0.0003) and 19 ± 39% (P = 0.18) at 25 and 50 mg exemestane, respectively. Free testosterone concentrations were increased by 117 ± 74% (P = 0.0001) and 154 ± 95% (P < 0.0001) at both doses, due to the decrease in SHBG and the increase in total testosterone."
"There were no changes in circulating serum triglycerides, cholesterol, or LDL or HDL cholesterol concentrations with either dose of exemestane."
The discussion section at the end summarizes:
"We report the first detailed study of the pharmacological effects of exemestane in male subjects. Doses of 25 and 50 mg were comparable in suppressing all circulating estrogens and had similar effects of increasing serum androstenedione and testosterone concentrations. There were 38%, 71%, and 45% decreases in estradiol, estrone, and estrone sulfate concentrations, respectively, after 10 d, approximately 24 h after administration of the last dose of 25 mg exemestane, coupled with 60% and 32% increases in testosterone and androstenedione concentrations. The rise in the aromatase substrates, testosterone and androstenedione, is probably secondary to substrate accumulation and/or to the feedback increase in gonadotropins caused by aromatase blockade."
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AnonOh my god bro this is just crazy what you're doing. Why the hell would you not using a LH stimulating Serm yet choose to use Aromadin in its place?
Hi Carlos. I am currently undertaking a second PCT to make up for my first which I agree turned out to be unwise. I'm taking Nolvadex now.
Per another recent post of mine prior to this one,
http://www.eroids.com/forum/steroids-qa/pct-anti-estrogens/hair-loss-on-...
I was experiencing hair-loss at a frightening rate 2 weeks into a Clomid PCT. There was/is literally huge bald spots on my head that seemed to occur overnight.
After researching Clomid, I learned that many Clomid users are experiencing the same type of hair-loss. I created that post asking about PCT alternatives for nat test restore. At the time, I was under the impression that Nolva was best for gyno and Clomid was best for nat test, which is why I didn't think Nolva was a viable option. I didn't get any valuable feedback from that post so I started researching on my own. I found this study on Aromasin. I read the entire study and concluded that it would be a sufficient replacement for Clomid for restoring nat test. Since then, I have been uncomfortable about this Aromasin only PCT. It never felt right to me, not taking a SERM. I think the problem with Aromasin might be crashed estrogen. Anyway, I found out that Nolva works for my needs which was a relief.
Am I the only one that didn't know Aromasin is a steroid? I thought an AI was an AI and a steroid was a steroid.
I've been learning all sorts of shit by reading these studies.
AnonAre you the only one? Probably not. Not many folks read up on the drugs they put in their body
Please read the rules.
http://www.eroids.com/forum/general/forum-rules/the-rules
http://www.eroids.com/rules-and-guidelines
The original article can be found here and at other places:
http://www.ugbodybuilding.com/archive/index.php/t-7358.html
I'm two days into taking the Aromasin and I'm drowning in lethargy. I read a study that says when estrogen crashes, testosterone cannot bind and do it's thing. So while blood tests in this study show increased test, the test is useless cause the receptors are down. It seems Aromasin is not the answer for PCT. I'm going to buck up, take the hair loss and finish my Clomid PCT.
Hey guys, if I have no problems with gyno, should I still be taking Nolvadex during PCT in addition to the Clomid, or can I just take Clomid?
I felt tired the first week or so when I first statarted aromasin. Your body gets used to it. Your estro isn't crashed if you've only been on it a few days. What's your dose?
I've actually been on it for 3 days. The first two days @ 25mg ED, 3rd day (yesterday) I upped the dosage to 50mg ED.
Holy hell, that's way too much. 12.5 mg a day is a standard dose. I've seen guys go up to 25 mg because their estro was super high, but it was only for a short time. Some crashed their estro at that dose.
You really need to get bloods to see where you're at. Until then, I wouldn't run it that high.
Thank you. I know that 25mg EOD/12.5 ED is standard on-cycle dosing. I suppose I thought after reading that study that a PCT dosage could be much higher. They gave men 25mg and 50mg in that study so I figured it would be safe.
Safe, probably, but it'll still crash you, which is not advisable. Aromasin has a short half life in men, so it should be dosed ED.
A study is one thing, but everyone's experience says differnt. Just trying to help you out here.
I understand. That makes sense. Thank you.
I'm still wondering if a PCT consisting of Aromasin only is not advised. It just doesn't seem right to me, as nobody else seems to have done this.
My only concern is restoring nat test. I don't have gyno issues. I'm willing to take a hair loss hit I suppose if Clomid is the only way. It's not worth losing my mojo over.
AnonIt's not only not advised its just silly and reckless. Do you really hate yourself that much?
To the General public please do not copy this individual.
Glad you found something that might work. Do you have a cycle history? And, if you have gotten bloodwork, what was your testosterone level?
On a side note, and other bros on here may agree, or disagree, but if you were to take aromasin/exemestane without exogenous testosterone, i believe your estrogen would crash, especially at the doses noted above.
I'm new to this, but I do have a cycle history. I've cycled 4 times. I've never done a hormone panel because following 4 weeks PCT in the past I have always bounced back. One time it took 5 weeks. I can tell I'm back to normal, or not, due to the state of my my sex drive. It's quite clear to me when I am shut down and when I am back in business. I did recently get blood tested to test everything else as I was concerned about liver and lipid values yet everything came back very good.
I'm 2 weeks into PCT now. I've stopped taking Clomid. I've started Aromasin 25mg ED. My sex drive is returning, but def not back to normal yet. We'll see how this works.
Its a good read but copy and paste is against the rules
Okay. What is up with that rule? How else am I suppose to share this information? It's from a publication that you have to pay to see online, so a link would only lead you to an abstract that does not contain this information.
Not true, I found this at a half dozen other sites. The one that matched your format the best I posted a link to above. Didn't cost a dime.
You can rephrase using your own words and provide a link, pay for or not.
Anything short of giving the author full credit is plagiarism.
Okay. I'll re-write and repost.