I've been reading through dozens of posts on aromatase inhibitors and many of them vary in dosing as well as times for dosing. Of course, we know by trial and error what inhibitor works for us as well as it may not be the same for others. So lets sidestep a second and visit the doctors office. Say you go to the doctor and get a script for amoxicillin. He directs you to take X mgs every Xhours and he/she will warn you that even though you will feel great in X days, to continue dosing until all the pills are gone. The reason is to keep the medicine even in your bloodstream so its effects are level.

So now take that back to the use of adex(anastrozole) and aromasin(exmastane). Adex has a half life of 3-3.5 days and aromasin is roughly 27hours. This is where time of administration is important. You take your inhibitor and it suppresses aromatase but if you're taking it late or at improper doses the trouble just begins. Taking it late allows for the once controlled estrogen to begin its rise in your system. Remember your body is always breaking down testosterone into its usable forms as well as forms we are trying to control. Now the inhibitor not only has to suppress this rise in estrogen but you'll realize there's side effects to hormonal peaks and valleys. For the same reason, many forums address proper injection times for steroids. Since everybody is different the common starting dosage for adex is .25mg every third day. Since there's not a significant androgen buildup til weeks 4-6, that dose for many is a safe bet. But as with all medications, as androgens buildup there's more conversion. Conversion does not stop. So changing the timing of adex dosing to .25 every other day may be needed. I like starting adex at the long end(.25 third day) on week 2 for a long ester cycle but with a bump-start of test prop or dbol then I start end of week 1 and adjust as necessary. Aromasin with the short half life of 27 hours requires daily dosing to avoid hormonal rise and fall. Keeping it level as well. I like to use my aromasin at 6.75 every day starting around week 3. As androgen buildup occurs around weeks 4-6 then I simply adjust my dose to 12.5 every day. If I bump-start with test prop or db I start at the end of week 1.

With either drug listening to your body is the important detail on adjusting. Blood tests taken at week 6 will allow fine tuning of your aromatase inhibitors which, will allow for not only better growth but many times, less sides.

Now lets take a minute and look at estrogen rebound. I've seen it mulled over on varied posts as well. During cycles you use your adex up til post cycle therapy. During the therapy its well versed to combine clomid and nolva. Now the bro-science will tell you there's no rebound in estrogen as the adex is removed. But don't forget two main items here, the Nolva and blood tests. Its standard procedure to submit blood a month after your cycle to readily see if you're recovering. But without taking blood in the second week of therapy we really do not know whether YOUR body has shown a rebound effect or not. But during the post cycle therapy phase, nolva is blocking your breast tissue. You're emotional, blues, agitated, and other symptoms of therapy and each person recovers differently. We typically wont know til after therapy stops and high estrogen side effects are kicking our butts and/or that blood test a month later. One thing we do know however is that aromasin is a suicide inhibitor. We know from prior postings that it holds onto that estrogen until its expelled from the body and there's no rebound effect.

Which, brings me to two conclusions which are switching to aromasin during cycle or using aromasin after adex is discontinued.