posted Mon, 09/10/2012 - 15:30
2087
Few Ai and PCT questions
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On third week of sustanon 250, 500mg a week pinning Mon/Thurs.
About to start Anastrozole, would .25mg EOD be good starting point or would you recommend .5mg EOD?
What is the best way to store the liquids Anastrozole, Tamoxifen and Exemestane (refrigerated etc?), and how long do they last?
Cheers in advance
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cdaddy7Don't forget the PCT...Start it 15 days after last test shot...It should look like this
Nolva 40/40/20/20
Clomid 100/100/50/0
***Take your AI until the day your PCT starts
Damnit fast!!! I was trying to edit my post!! It's okay...
...Hey, 'steel001'...obviously this is your first cycle, why did you choose sust? You should have done more research before you started, and where's your clomid at!!!!????
.25 e3d unless you're sensitive then its .25eod.. Storing liquids like that in fridge is okay but its a suspension so SHAKE THE CRAP OUTTA IT. It settles.
Good point re: suspension and shaking...thx for the tip.
Cheers fast will start at .25 E3D and see how I go
And if this is your first cycle listen to superdbag. Sust is difficult for new folks. Its got lots of fluctuations.
Second Cycle, first was sus too but only 250mg once a week.
Knew little about injecting then (and still do) but responded well to it. Am trying to look after everything better this time thats why I'm getting bloods done every few weeks, don't mind the cost I would just prefer to know where I'm at.
Thanks to every one here though, its a learning curve for sure.
Well, good for you to get blood work throughout. Can't say I really have been the best at that in the past, but things change. How are you pinning that shit?...EOD or just like Mon, Wed, Fri? You do know that because you are doing sust, that you are gonna have a pretty nice lengthy 'crash' time before you start PCT. It's gonna be more than 15 days (like for test E)
Was pinning Mon/Thurs to begin with but now upped it to Mon/Wed/Fri after some advice from Zewi. Yeah I was going to start PCT after 15 days, may have to rethink what I use for my next cycle.
If you're doing 500mg sust/wk., then PCT will start around 21+ days after last inject. Reason being is that you will have a build-up of long estered test in your system that needs to clear out before embarking on recovery.
pinning M/W/F is good though!! Good job listening!! Both zewi and fast know their shit!!
Big high five for using the resources here!
Cheers mate
AnonOk, i've produced a breakdown for you in order to:
1) Uncerstand what Nolva is/does
2) Understand what an AI is
3) Understand the two types of AI
4) When to use an AI/PCT
5) Knowledge about PCT/SERMs
Nolvadex- increases in the serum levels of LH, FSH, and most importantly, testosterone. And also helps block estrogen. However, it helps your body increase your sperm count because of that. In fact the bad thing about Nolvadex unlike Clomid is that it doesn’t on its own increase sperm count or their motility. However, you still needed it because it does increase your LH and FSH which we need for healthy testis.
Aromatase Inhibitors come in 2 types. Type 1 and Type 2. First Type 1 AI's bind by a process called hydroxylation; this hydroxylation process produces an unbreakable covalent bond between the inhibitor and the enzyme protein. Now the enzyme is permanently blocked even after all of the inhibitor is removed and can only be resumed by new enzyme synthesis. Type 2 Inhibitors on the other hand function all the same in their ability to reduce the binding process of the enzyme and the receptor. Except once the drug is discontinued or the concentration of the drug is sparse enough it is possible for the enzyme to seperate itself from the Inhibitor and eventually will allow renewed competion between the Inhibitor and the Enzyme for the receptor site. Aromasin is a type 1 AI and once it does what it's purpose is we don't need to continue use. Letro and Adex are Type 2 Ai's and the success of those drugs are continigent on the Doses and protocol of which we use them. Once you stop them you expose yourself to an Estrogen rebound. Now having said all of that there are also many other reason to why Aromasin use is beneficial to a Bodybuilder. One is Arimidex/Anastrozole Decreases IGF-1 18% while Aromasin/Exemestane Increases IGF-1 28%. Another is Aromasin is also known to decrease estrogen between 90-95% while boosting Endogenous Testosterone by about 60%, and also help out your free to bound testosterone ratio by lowering levels of Sex Hormone Binding Globulin (SHBG), by about 20% (12)…SHBG is that nasty enzyme that binds to testosterone and renders it useless for building muscle.
SERM- Selective Estrogen Receptor Modulator- are a class of compounds that act on the estrogen receptor. A characteristic that distinguishes these substances from pure receptor agonists and antagonists is that their action is different in various tissues, thereby granting the possibility to selectively inhibit or stimulate estrogen-like action in various tissues. Clomid and Nolvadex are examples of these.
Mode of Action for SERM
Estrogenic compounds span a s
pectrum of activity ranging from:
1) Full agonists (agonistic in all tissues) such as the natural endogenous hormone estrogen
2) Mixed agonists/antagonistics (agonistic in some tissues while antagonist in others) such as tamoxifen (a SERM)
3) Pure antagonists (antagonistic in all tissues) such as fulvestrant (ICI-182780).
You want either adex/asin on cycle at the following doses:
Aromasin @ 12.mg EOD
Arimidex 0.25mg EOD if nipples get sore than 0.5mg EOD if still sore 0.5mg EOD.
References:
Cdaddy7 - (http://www.eroids.com/forum/steroids-qa/pct-anti-estrogens/ais-in-pct-to...)
GS9902 - (http://www.eroids.com/forum/steroids-qa/pct-anti-estrogens/pct-and-aromasin)
Great read, clarifies a few things. Will start at .25 E3D and see how I go
AnonNo problem man! Hope everything goes well! Keep us posted. But I also wonder why you went for Sust as your first test....
You can start at .25mg E3D...and then change it from there to EOD and then up the dose to .5mg depending on your sides and how you feel in general. Adex is usually very good at .5mg EOD for most people, but we are all different.
The trick is to find your sweet spot in estrogen conversion. Really, the best way to find your sweet spot is to get a blood test midway thru your cycle and see where your estradiol is at...and then you can judge how you feel where that level is at and then shoot from there for the rest of your cycle, and also for future reference for future cycles.
You don't need to store your AI's in the fridge...just a cool, dark place. You got clomid for your pct too???
Had my bloods done its in another post, estrogen was a little high but doc said it was still in normal range so will go with .25 E3D .
Got bloods booked again for four weeks time so if my levels dont come down I will increase the dose and do them again a few weeks after.
I have Clomid in tablet form as was going to follow the documented Eroid guidelines for PCT dosage. I have Exemestane but only 30mg so was going to put it aside for another cycle and use the Anastrozole this time.
Cheers for the advice mate.
Will post bloods after I get them done again in four weeks time.
Ya! What he said!